Amiloidosis nodular primaria cutánea localizada en un paciente con paraproteinemia

Villar, M.; Burgués, María Eugènia Alegret i; Rodríguez‐Peralto, José Luis; Rivera, R.; Vanaclocha, F.

doi:10.1016/j.ad.2011.05.017

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Primary cutaneous nodular amyloidosis is a rare form of localized cutaneous amyloidosis. 1 It usually presents as waxy infiltrated plaques and nodules, most commonly on the trunk or extremities. 1 Secondary ulceration has rarely been described.…”

Section: Discussionmentioning

confidence: 99%

“…Primary cutaneous nodular amyloidosis is a rare form of localized cutaneous amyloidosis presenting as waxy infiltrated plaques and nodules. 1 Its clinical appearance sometimes resembles that of systemic amyloidosis. 1 Secondary ulcers have rarely been described.…”

Section: Introductionmentioning

confidence: 99%

“…1 Its clinical appearance sometimes resembles that of systemic amyloidosis. 1 Secondary ulcers have rarely been described.…”

Section: Introductionmentioning

confidence: 99%

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Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report

Fernandes

Éthier

Marouan

et al. 2019

SAGE Open Medical Case Reports

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Introduction and objectives:The main objective of this article is to present and discuss a case of localized ulcerative nodular amyloidosis with deep involvement clinically manifesting as ulcerative panniculitis and discuss its impact on the choice of treatment.Methods and results:We present a 73-year-old woman with a history of painful ulcerated nodules on the inferior limbs. Microscopy confirmed amyloid deposits deep in the dermis and subcutaneous fat. No systemic involvement was found. Considering that skin-directed treatments often are not able to reach subcutaneous fat or were contraindicated because of the ulcers, she was successfully treated with cyclophosphamide and prednisone.Conclusion:Localized ulcerative nodular amyloidosis with deep involvement is a rare clinical presentation that can present as ulcerative panniculitis. Such a clinical manifestation might be misleading. Systemic treatment might be necessary to control symptoms when conventional skin-directed therapies are contraindicated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report

Fernandes

Éthier

Marouan

et al. 2019

SAGE Open Medical Case Reports

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“…The localized cutaneous amyloidosis is a rare type of amyloidosis in which extracellular amyloid substance deposits are located only in the skin, and includes three variants: lichenoid, macular and nodular amyloidosis. 6,8,9,10 The lichenoid and the macular amyloidosis are often grouped together, since both have constituents derived from keratin on amyloid deposits, that do not invade the blood vessels and do not extend below the papillary dermis. 6,8 The nodular amyloidosis is the rarest variant, 5,6,8,9 its amyloid deposits are formed by immunoglobulin light chains (AL amyloid | 171 | substance type) 6,8,9 produced by local plasma cells, 6,11 infiltrating the entire dermis, the subcutaneous layer and the blood vessel wall.…”

Section: Discussionmentioning

confidence: 99%

“…6,8,9,10 The lichenoid and the macular amyloidosis are often grouped together, since both have constituents derived from keratin on amyloid deposits, that do not invade the blood vessels and do not extend below the papillary dermis. 6,8 The nodular amyloidosis is the rarest variant, 5,6,8,9 its amyloid deposits are formed by immunoglobulin light chains (AL amyloid | 171 | substance type) 6,8,9 produced by local plasma cells, 6,11 infiltrating the entire dermis, the subcutaneous layer and the blood vessel wall. 6,8 The AL protein is not specific for the nodular cutaneous amyloidosis, it also exists in the primary systemic amyloidosis or the amyloidosis associated with multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

Nodular primary localized cutaneous amyloidosis: presentation of 2 case reports and literature review

Rosado¹,

Neves²,

Cruz³

et al. 2015

Gal. Clin.

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The nodular primary localized cutaneous amyloidosis is rare and characterized by skin deposition of amyloid substance. There are cases of progression to invasive disease. The type of amyloid substance is not specific to this disease, also being found in primary systemic amyloidosis or systemic amyloidosis associated with multiple myeloma. The authors describe two cases of nodular primary localized cutaneous amyloidosis. A 70-year-old man underwent excision of papule on the mouth left commissure, and a 39-year-old woman with a vulva's labia majora swelling that was excised, in which the histology revealed a nodular amyloidosis, both without systemic involvement. Although the prognosis is benign, the follow-up of the patient is required for early detection of a possible evolution to systemic disease, or exclusion of an underlying systemic amyloidosis.

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Placa en la nariz

Unamuno‐Bustos

Ballester‐Sánchez

Miquel

2014

Actas Dermo-Sifiliográficas

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Amiloidosis nodular primaria cutánea localizada en un paciente con paraproteinemia

Cited by 4 publications

References 8 publications

Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report

Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report

Nodular primary localized cutaneous amyloidosis: presentation of 2 case reports and literature review

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