Amidrazones in the Synthesis of 1H‐1,2,4‐Triazoles.

Abstract

Triazole derivatives R 0280Amidrazones in the Synthesis of 1H-1,2,4-Triazoles. -A convenient one-step procedure for the synthesis of various indanylidenetriazoles (III) via reaction of amidrazones (I) with (indanylidene)malononitriles (II) is reported. -(ALY*, A. A.; GOMAA, M. A.-M.; NOUREL-DIN, A. M.; FAHMI, M. S.

On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas

“…Chelating thiourea ligands containing N, S and O donor atoms show broad biological activity and the existence of metal ions bonded to biologically active compounds may enhance their activities, and it was shown that the mode of binding of platinum to DNA is affected by the substituent nature on the acyl thiourea [4]. Acyl thiourea derivatives have been increasingly important with a wide diversity of applications in heterocyclic chemistry, metal complexes, molecular electronics and exhibit an array of biological activities [5][6][7][8][9]. Some of them are employed as fungicidal, antiviral, antimicrobial [10], parasiticidal [11], antitumoral [12] and pesticidal agent [13][14][15].…”

Synthesis, structural and vibrational properties of 1-(4-Fluorobenzoyl)-3-(isomeric fluorophenyl)thioureas

“…1-Aroyl-3-arylthioureas found a wide diversity of applications in heterocyclic syntheses, metal complexes and molecular electronics and exhibit an array of biological activities [1][2][3][4]. Thus, besides the academic interest, N,N-dialkyl-N 0 -aroyl thioureas are efficient ligands for the separation of platinum group metals [5].…”

“…N-Aryl N-phenyl thioureas have been developed as anion-binding site in a hydrogen-bonding receptor [10]. Thiacalix [4] arenes containing thioureas are neutral receptors towards a,a-dicarboxylate anions [11] and N-4-substituted-benzyl-N 0 -ter-butylbenzyl thioureas are vanilloid receptors ligands and antagonists in rat DRG neurons [12]. 1-Benzoyl-3-(4,6-disubstituted-pyrimidinyl) thioureas have shown excellent herbicidal activity [13].…”

Reaction of Amidrazones with Phthaloyl Chloride—Synthesis of 1,2,4‐Triazolium Salts (Part I)

“…N-Phenylamidrazones provide a highly variable source for the synthesis of nitrogen containing heterocycles [15]. Moreover, they exhibit a great variety of biological activities, among which are corticotrophin releasing factor receptor antagonists, insecticides, or sphingosine-1-phosphate receptor 3 (S1P3) antagonists as well [16].…”