On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas

Study on Semiconductor Properties of Acetylide-Thiourea Fabricated onto Interdigitated Electrodes (Ides) Platform Towards Application In Gas Sensing Technology

“…Whilst, stretching frequencies at 1341 cm -1 corresponds to vibration of ν(C-N). Indeed, the most important functional group was observed for the existence of C=S band with medium intensity at 833 cm -1 [32] which located at low frequency due to the less double bond character with low nucleophilic character of the sulfur atom [33] in C=S moiety of TCN.…”

Synthesis and Bioactivity Evaluation of Acylthiourea Derivatives Based on Isopimaric Acid

“…酰基硫脲和酰胺基硫脲化合物是两类重要的硫脲 类衍生物, 也是重要的有机硫化合物. 这两类硫脲类衍 生物都具有广泛的生物活性, 如植物生长调节 [15] 、抗病 毒 [16] 、抗菌 [17,18] 和抗癌 [19,20] [21] . 当 R 为噻唑基(Th)时, NH 质子位移比 R 为苯 基(Ph)时位移要大; Ph 或 Th 上连有供电子取代基时, NH 化学位移移向高场; 连有吸电子取代基时, 则 NH 化学 位移移向低场 [22] .…”

Structure/Activity of PtII/N,N-Disubstituted-N’-acylthiourea Complexes: Anti-Tumor and Anti-Mycobacterium tuberculosis Activities

“…20 The complexes were separated from the reaction mixtures as white crystalline solids. Filtration and further washing with hot water and hot hexane were enough to afford pure compounds, in about 80% yields.…”

“…[13][14][15] In previous works, [16][17][18][19][20] some of us synthesized and determined the structures of some ligands related to those here described, and their corresponding complexes with Co II , Cu II , Ni II , Pd II and Pt II were also studied, which contain a thiourea derivative as a bidentate ligand, in different environments. In the present work, we studied the syntheses, characterization, cytotoxicity and anti-Mycobacterium tuberculosis activity of new platinum(II) complexes containing PPh 3 and N,N-disubstituted-N'-acylthioureas as ligands.…”

“…16 Cytotoxic studies realized on DU-145 (human prostate tumor cells) and MDA-MB-231 (human breast tumor cells) tumor cell lines have shown that certain palladium(II) complexes with the acylthiourea ligands exhibit cytotoxicity with antiproliferative effects being dependent on the nature or the type of the substituent at the acylthiourea ligand. 20 Recently there have been efforts to design non-classical platinum-acylthiourea complexes, due to their antifungal activity and inhibitory activities against viruses. Thus, here we investigate the cytotoxicity of the complexes against MDA-MB-231 and DU-145 tumor cells, and their anti-Mycobacterium tuberculosis activity, with the aim of evaluating a possible influence of R1 and R2 in the cytotoxicity and in the anti-mycobacterial activity of the complexes.…”