Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer

Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kousei; Ushijima, Yasuhiro; Takayama, Yoshiaki; Okamoto, Daisuke; Fujita, Nobuhiro; Tsurumaru, Daisuke; Togao, Osamu; Sagiyama, Koji; Manabe, Tatsuya; Oki, Eiji; Kubo, Yuichiro; Hida, Tomoyuki; Hirahashi-Fujiwara, Minako; Keupp, Jochen; Honda, Hiroshi

doi:10.1111/jgh.14315

Cited by 32 publications

(31 citation statements)

References 39 publications

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“…DCE-MRI of rectal cancer demonstrated that tumors with better perfusion showed greater nodal and tumor downstaging after radiotherapy than poorly perfused tumors (38). However, our result on APT changes after NCRT contrasted with that of Nishie et al, who found that pretherapeutic mean APTw SI of low-response group was significantly higher than that of the high-response group (29). This difference may be explained by the fact that Nieshi et al used a different TRG grading criteria, which is according to necrosis or cytological changes of the tumor.…”

Section: Discussioncontrasting

confidence: 99%

“…Several studies have reported that APTw imaging helps differentiate between pseudo-progression, radiation necrosis, and tumor recurrence in gliomas ( 25 )—it is superior to conventional MRI contrasts as well as to advanced functional imaging methods such as perfusion (dynamic susceptibility contrast and dynamic-contrast-enhanced) and spectroscopy ( 24 , 26 – 28 ). However, only one study assessed APTw MRI in evaluating the effect of chemoradiotherapy in LARC ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

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Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

Chen

Mao

et al. 2021

Front. Oncol.

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ObjectiveTo evaluate amide proton weighted (APTw) MRI combined with diffusion-weighted imaging (DWI) in predicting neoadjuvant chemoradiotherapy (NCRT) response in patients with locally advanced rectal cancer (LARC).Methods53 patients with LARC were enrolled in this retrospective study. MR examination including APTw MRI and DWI was performed before and after NCRT. APTw SI, ADC value, tumor size, CEA level before and after NCRT were assessed. The difference of the above parameters between before and after NCRT was calculated. The tumor regression grading (TRG) was assessed by American Joint Committee on Cancer’s Cancer Staging Manual AJCC 8th score. The Shapiro-Wilk test, paired t-test and Wilcoxon Signed Ranks test, two-sample t-test, Mann-Whitney U test and multivariate analysis were used for statistical analysis.ResultsOf the 53 patients, 19 had good responses (TRG 0-1), 34 had poor responses (TRG 2-3). After NCRT, all the rectal tumors demonstrated decreased APT values, increased ADC values, reduced tumor volumes and CEA levels (all p < 0.001). Good responders demonstrated higher pre-APT values, higher Δ APT values, lower pre- ADC values and higher Δ tumor volumes than poor responders. Pre-APT combined with pre-ADC achieved the best diagnostic performance, with AUC of 0.895 (sensitivity of 85.29%, specificity of 89.47%, p < 0.001) in predicting good response to NCRT.ConclusionThe combination of APTw and DWI may serve as a noninvasive biomarker for evaluating and identifying response to NCRT in LARC patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

Chen

Mao

et al. 2021

Front. Oncol.

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“…APT imaging is not limited to central nervous system tumors or ischemic lesions (13)(14)(15)(16); more recently, it has been gradually developed and applied to the diagnosis of various system diseases (17)(18)(19)(20), but its application in aMCI is still in its infancy. The limbic system is a set of brain structures involved in emotion, learning, and memory, which are central to cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Amide Proton Transfer-Weighted MRI Might Help Distinguish Amnestic Mild Cognitive Impairment From a Normal Elderly Population

et al. 2021

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Objectives: To evaluate whether 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis can be used as a novel imaging marker to distinguish amnestic mild cognitive impairment (aMCI) patients from the normal elderly population by measuring changes in APTw signal intensity in the hippocampus and amygdala.Materials and Methods: Seventy patients with aMCI and 74 age- and sex-matched healthy volunteers were recruited for routine MRI and APT imaging examinations. Magnetic transfer ratio asymmetry (MTRasym) of the amide protons (at 3.5 ppm), or APTw values, were measured in the bilateral hippocampus and amygdala on three consecutive cross-sectional APT images and were compared between the aMCI and control groups. The independent sample t-test was used to evaluate the difference in APTw values of the bilateral hippocampus and amygdala between the aMCI and control groups. Receiver operator characteristic analysis was used to assess the diagnostic performance of the APTw. The paired t-test was used to assess the difference in APTw values between the left and right hippocampus and amygdala, in both the aMCI and control groups.Results: The APTw values of the bilateral hippocampus and amygdala in the aMCI group were significantly higher than those in the control group (left hippocampus 1.01 vs. 0.77% p < 0.001; right hippocampus 1.02 vs. 0.74%, p < 0.001; left amygdala 0.98 vs. 0.70% p < 0.001; right amygdala 0.94 vs. 0.71%, p < 0.001). The APTw values of the left amygdala had the largest AUC (0.875) at diagnosis of aMCI. There was no significant difference in APTw values between the left and right hippocampus and amygdala, in either group. (aMCI group left hippocampus 1.01 vs. right hippocampus 1.02%, p = 0.652; healthy control group left hippocampus 0.77 vs. right hippocampus 0.74%, p = 0.314; aMCI group left amygdala 0.98 vs. right amygdala 0.94%, p = 0.171; healthy control group left amygdala 0.70 vs. right amygdala 0.71%, p = 0.726).Conclusion: APTw can be used as a new imaging marker to distinguish aMCI patients from the normal elderly population by indirectly reflecting the changes in protein content in the hippocampus and amygdala.

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“…In fact, mucin‐containing tumors—known to be unresponsive to chemotherapy—have been successfully stratified by APT MRI, as they yield higher APT signal intensities. The technique also predicted tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer 6 …”

mentioning

confidence: 99%

“…The technique also predicted tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer. 6 The ability to correlate quantitative imaging parameters with histopathology or oncogenic protein markers, such as the tumor protein p53 and Ki-67 index, would play a critical role in the assessment of prognostic factors for rectal adenocarcinoma, and it is an almost unexplored field.…”

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confidence: 99%

Editorial for “Comparative Analysis of Amide Proton Transfer MRI and Diffusion‐Weighted Imaging in Assessing p53 and Ki‐67 Expression of Rectal Adenocarcinoma”

Canese

2020

Magnetic Resonance Imaging

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Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer

Abstract: Pretherapeutic APT imaging can predict the tumor response to NAC in patients with LARC.

Cited by 32 publications

References 39 publications

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

Amide Proton Transfer-Weighted MRI Might Help Distinguish Amnestic Mild Cognitive Impairment From a Normal Elderly Population

Editorial for “Comparative Analysis of Amide Proton Transfer MRI and Diffusion‐Weighted Imaging in Assessing p53 and Ki‐67 Expression of Rectal Adenocarcinoma”

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