Amide–Iminoate Isomerism in Antineuroinflammatory Isoquinoline Alkaloids from <i>Stephania cepharantha</i>

Xiao, Jiangjian; Song, Junyu; Lin, Bin; Li, Wei; Yang, Yanqiu; Liu, Jingyu; Hou, Yue; Chen, Gang; Li, Ning

doi:10.1021/acs.jnatprod.9b00483

Cited by 21 publications

(2 citation statements)

References 18 publications

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“…Sceletium contains alkaloids of the mesembrine type, including Δ 7 mesembrenone, mesembranol, mesembrenone, mesembrine, and epimesembranol, which are used as a traditional medicine in South Africa to treat neurodegenerative disease [ 59 ]. In the Guangxi and Yunnan provinces of China, Stephania cepharantha has been widely used to treat stomach aches and snakebites, and the alkaloids present in it have been found to possess potential anti-neuroinflammatory agents [ 60 ]. We have also tried to report and shed light on the listed alkaloids in Table S2 comprehensively.…”

Section: Ethnopharmacological Survey Of Plants Producing Therapeutic ...mentioning

confidence: 99%

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

Aryal

Raut

Bhattarai

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Alkaloids are a type of natural compound possessing different pharmacological activities. Natural products, including alkaloids, which originate from plants, have emerged as potential protective agents against neurodegenerative disorders (NDDs) and chronic inflammations. A wide array of prescription drugs are used against these conditions, however, not free of limitations of potency, side effects, and intolerability. In the context of personalized medicine, further research on alkaloids to unravel novel therapeutic approaches in reducing complications is critical. In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-κB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and β-site amyloid precursor protein activity. In silico ADMET and ProTox-II-related descriptors were calculated to predict the pharmacological properties of 280 alkaloids isolated from traditional medicinal plants towards drug development. Out of which, eight alkaloids such as tetrahydropalmatine, berberine, tetrandrine, aloperine, sinomenine, oxymatrine, harmine, and galantamine are found to be optimal within the categorical range when compared to nicotine. These alkaloids could be exploited as starting materials for novel drug synthesis or, to a lesser extent, manage inflammation and neurodegenerative-related complications.

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Section: Ethnopharmacological Survey Of Plants Producing Therapeutic ...mentioning

confidence: 99%

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

Aryal

Raut

Bhattarai

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The inhibitory activity of alkaloids on NO release from BV-2 microglial cells was tested by the Griess method as described in a previous report. 34 In brief, 100 μL of BV-2 microglial cells at a density of 2 × 10 3 cells/mL was seeded in 96-well plates and incubated under 5% CO 2 at 37 °C for 24 h. Then, the cells were treated with LPS and different concentrations of compounds (1, 10, 25, and 50 μM) at 37 °C for 20 h. Minocycline was used as a positive control. Each treatment was performed in triplicate.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum

Zheng

Wang

et al. 2021

J. Nat. Prod.

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Three new tyramine-type alkamides (1–3), three new natural products (4–6), five new N-acylated/formylated aporphine alkamides with different ratios of rotational isomers (7–11), and 20 known alkamides (12–31) were isolated from an EtOH extract of the stems and leaves of Piper puberulum. The absolute configurations of compounds 7, 8, and 10 were determined by single-crystal X-ray diffraction analysis. In the biological activity assay, compounds 3, 5, and 10–23 displayed inhibitory effects against lipopolysaccharide-induced NO release in BV-2 microglial cells, exhibiting IC50 values of 0.93–45 μM.

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Metabolites from Michelia compressa var. lanyuensis with Antioxidant Activity

Chang,

Li,

et al. 2024

Chem Nat Compd

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Amide–Iminoate Isomerism in Antineuroinflammatory Isoquinoline Alkaloids from Stephania cepharantha

Cited by 21 publications

References 18 publications

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum

Metabolites from Michelia compressa var. lanyuensis with Antioxidant Activity

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