Three new tyramine-type alkamides
(1–3), three new natural products
(4–6), five new N-acylated/formylated aporphine
alkamides with different ratios of rotational isomers (7–11), and 20 known alkamides (12–31) were isolated from an EtOH extract of the
stems and leaves of Piper puberulum. The absolute
configurations of compounds 7, 8, and 10 were determined by single-crystal X-ray diffraction analysis.
In the biological activity assay, compounds 3, 5, and 10–23 displayed inhibitory
effects against lipopolysaccharide-induced NO release in BV-2 microglial
cells, exhibiting IC50 values of 0.93–45 μM.
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