Amidated pectin/sodium carboxymethylcellulose microspheres as a new carrier for colonic drug targeting: Development and optimization by factorial design

Gadalla, Hytham H.; El-Gibaly, I.; Soliman, Ghareb M.; Mohamed, Fardous A.; El‐Sayed, Ahmed M.

doi:10.1016/j.carbpol.2016.08.018

Cited by 47 publications

(33 citation statements)

References 52 publications

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“…The particles were tested in colon-targeted drug delivery. [ 129 ] Chitosan Ovalbumin Porous chitosan microparticles, which can be taken up by the epithelium of the Peyer's patches, were synthesized and used as a vaccine delivery system. [ 130 ] Curcumin A sustained release of curcumin in the intestinal tract was reported for N-trimethyl chitosan modified SLNs.…”

Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

154

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

154

View full text Add to dashboard Cite

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“…In comparison with LM pectins, they require less calcium for gelation and the resulting gel is also perfectly thermally reversible (Marudova & Jilov, 2003). Amidated pectin can be combined with sodium carboxymethyl cellulose to construct a microsphere delivery system (Gadalla et al , 2016). Chaux‐Gutiérrez et al (2019) reported the rheological characteristics of gels from albumin and low‐methoxyl amidated pectin mixtures, which provide potential for LMA to combine with protein to form particles suitable for stabilising Pickering emulsion.…”

Section: Introductionmentioning

confidence: 99%

Gliadin/amidated pectin core–shell nanoparticles for stabilisation of Pickering emulsion

Jiang

Zhu

2020

Int J of Food Sci Tech

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Over the past decade, edible colloidal particle-stabilised Pickering emulsions have regained research interest. However, little information is available regarding the application of amidated pectin in stabilising Pickering emulsions. In this work, a 'two-step' method was used to synthesise gliadin/pectin composite colloidal particles. The effects of pectin type, particle ratio, particle amount and oil fraction on the formation and stability of the resulting Pickering emulsion were systematically investigated by particle size and microscopy. The results showed that the particles formed after the addition of amidated pectin could better stabilise the o/w Pickering emulsion with a concentration of 2%, lower than that of the gliadin colloid particles. Confocal laser scanning microscopy (CLSM) revealed the cross-sectional structure and the attachment of protein particles to the external interface. These results may provide reference for the selection of shell materials for Pickering colloidal particles (especially gliadin) in the future.

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“…To overcome these issues, much of the recent work in the field has focused on novel colontargeted delivery systems based on polysaccharides (de Vos et al 2010;Rudzinski et al 2016;Seeli and Prabaharan 2017). Polysaccharides may be effective carriers for colonic delivery systems because many can avoid digestion by the bioactive components in the upper gastrointestinal tract, but can then be digested by the enzymes produced by colonic microbiota or by the bioactive components of the colon (Freire et al 2009;Gadalla et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro Release Mechanisms of Modified Pectin Matrix Tablets for Colon-Targeted Drug Delivery

Lei

et al. 2017

BioResources

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To deliver bioactive components to the colon, an oral, colon-targeted, microparticle delivery system was developed based on pectin. Pectin was modified by mechanical activation, resulting in controllable release properties, as well as dramatic decreases in solubility. Mechanically activated pectins (MAP) were characterized by Fourier transformed infrared (FTIR) spectroscopy, nuclear magnetic resonance ( 1 H-NMR) spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The FTIR and 1 H-NMR analyses revealed that after mechanical activation, the hydrogen bonds between pectin molecules were broken, and intermolecular crosslinking was decreased. The DSC analysis indicated that the thermal stability of pectin was decreased by mechanical activation. The SEM revealed that MAP particles were smaller, more uniform, and had smoother surfaces than unmodified pectin. An in vitro release assay and the study of drug release kinetics demonstrated that bovine serum albumin (BSA) release from MAP-containing matrix tablets was controllable. The results demonstrated that at a suitable pectin content and hydrophobicity level, matrix tablets prepared with MAP can exhibit good colon-targeted drug release.

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Amidated pectin/sodium carboxymethylcellulose microspheres as a new carrier for colonic drug targeting: Development and optimization by factorial design

Cited by 47 publications

References 52 publications

Micro and nanoscale technologies in oral drug delivery

Micro and nanoscale technologies in oral drug delivery

Gliadin/amidated pectin core–shell nanoparticles for stabilisation of Pickering emulsion

Preparation and in vitro Release Mechanisms of Modified Pectin Matrix Tablets for Colon-Targeted Drug Delivery

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