Amibiase expérimentale. Obtention du type pathogène de <i>E. histolytica</i> chez la souris blanche rendue immunotolérante

Lancastre, F.; Bazin, J. C.; Fichoux, Y. Le; Mougeot, G; Gargouri, M.; Lotti, Anita; Bolognini, J.

doi:10.1051/parasite/1968436623

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…The mouse has been re-investigated using outbred (Westphal, 1970) and inbred strains (Neal & Harris, 1977), but without reporting a highly susceptible host. Prior injection of egg albumin was reported by Lancastre, Bazin, Le Fichoux, Mougeot & Gargouri (1968) to render the mice more susceptible to caecal infection.…”

Section: Methods For Experimental Study Of Anti-parasite Activitymentioning

confidence: 99%

Experimental amoebiasis and the development of anti-amoebic compounds

Neal

1983

Parasitology

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In the ideal situation, the development of new amoebicides, or more accurately anti-amoebic compounds which are compounds with activity against Entamoeba histolytica, should initially proceed with the study of parasite-specific metabolic pathways and their inhibition, followed by whole parasite in vitro studies, experimental in vivo models and finally clinical trial. However, there are considerable gaps in our knowledge which will be discussed below, and consequently many investigators consider that empirically selected compounds should be tested experimentally in addition to specifically designed compounds. Before clinical trials can begin, extensive examination of the candidate amoebicide in experimental animals is required in order to investigate possible toxicological hazards.In addition to inhibiting the amoebic parasite, the drug has to reach the parasite in several different sites in the body, thus there is also a problem of pharmacokinetics and distribution. Prior to the discovery of the nitroimidazole class of amoebicides, the multi-site attack was solved by the use of several drugs, sometimes in sequence during the treatment of an individual case (Powell, 1972). The discovery of the nitroimidazole class of compound changed the situation dramatically and these have shown a clinical and parasitological effect against extra-intestinal and intestinal wall infections. The effect on intralumenal infection (that is mildly symptomatic or asymptomatic infections) of the large intestine is, however, less certain (Finegold, 1977; Spillman, Ayala & Sanchez, 1976).Although the treatment of amoebiasis appears to be satisfactory at the present time, it is difficult to predict problems which might arise in the future, and therefore it is valuable to continue the pre-clinical development, especially the investigation of parasite metabolism, in order to define parasite-specific points of chemotherapeutic attack.The chemotherapy of amoebiasis was reviewed comprehensively by Woolf (1963, 1965). The present account of the development of amoebicides therefore starts from the Woolfe reviews.

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Section: Methods For Experimental Study Of Anti-parasite Activitymentioning

confidence: 99%

Experimental amoebiasis and the development of anti-amoebic compounds

Neal

1983

Parasitology

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Amoebiasis

Fernex¹

1972

Rickettsiosen Und Protozoenkrankheiten

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Pathogenicity of entamoeba histolytica

Kagan¹

1975

Infection

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The pathogenicity of Entamoeba histolytica is discussed from an immunologic point of view. The evidence that there is some "trigger" mechanism which converts a commensal dwelling organism into a tissue invasive pathogen is rejected as inadequate. The number of liver abscess cases in comparison with the number of intestinal amebic infections in a population is so low that this in itself suggests that tissue invasion is a rare event in the life history of the ameba. A review is made of the experimental evidence that some type of sensitization is necessary before ameba can invade tissue. In postulating an immunologic basis for the pathogenicity of ameba, a parallel between the behavior of malignant cells in the body and an amebic infection in the gut is made. An appealing hypothesis which deserves further research effort is that an altered immune response is the basis for the pathogenic mechanism in the host.

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Amibiase expérimentale. Obtention du type pathogène de E. histolytica chez la souris blanche rendue immunotolérante

Cited by 4 publications

References 3 publications

Experimental amoebiasis and the development of anti-amoebic compounds

Experimental amoebiasis and the development of anti-amoebic compounds

Amoebiasis

Pathogenicity of entamoeba histolytica

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