American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry and the IRIS Registry Analytic Center Consortium

Abstract

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Lessons From The Glaucoma Foundation Think Tank 2023: A Patient-Centric Approach to Glaucoma

“…The IRIS registry represents a clinical repository organized by the American Academy of Ophthalmology, and it is considered the largest medical specialty database in the world, with 483.6 million visits and 78.6 million patients as of January 1, 2023, from sites across the United States 33,34 . Currently, 70% of US ophthalmologists contribute data to IRIS.…”

“…The IRIS registry represents a clinical repository organized by the American Academy of Ophthalmology, and it is considered the largest medical specialty database in the world, with 483.6 million visits and 78.6 million patients as of January 1, 2023, from sites across the United States. 33,34 Currently, 70% of US ophthalmologists contribute data to IRIS. While the size of this database is a major asset, it does not include nonophthalmic data, visual field, optic disc photographs, or optical coherence tomography (OCT) data.…”

The evolving field of Big Data: understanding geographic information systems analysis and its transformative potential in ophthalmic research

“…Most seminal observational studies [31,32] and the newer IRIS Registry data [5,33,34] are limited to a single locale, provide no geographic detail, or report on the four US census regions [35]. In some cases, patient privacy safeguards limit the geographic information contained in the data [36]. Further discussion of the challenges of geographic information will be discussed in a later section.…”

Predictors of Long-term Ophthalmic Complications after Closed Globe Injuries Using the IRIS® Registry (Intelligent Research in Sight)

“… 13 , 27 , 28 In the absence of an active registry devoted to eye injuries, we used the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry, a national database containing electronic health record data from 65 million unique patients and thousands of participating eye care providers to study closed globe ocular trauma. 29 This comprehensive database has been employed in a variety of research domains including epidemiological reporting and biomarker discovery, as well as risk factor and practice pattern analysis. 30 , 31 , 32 , 33 In this study, we evaluated patients with closed globe ocular trauma within the IRIS Registry in order to identify baseline clinical factors associated with various ophthalmic complications, including the need for and timing of future surgical intervention.…”