Ameloblastic Fibrosarcoma of the Mandible: A Case Report and a Review of the Literature

Shetawi, Haitham Al; Alpert, Erin H.; Buchbinder, Daniel; Urken, Mark L.

doi:10.1016/j.joms.2015.03.066

Cited by 13 publications

(23 citation statements)

References 24 publications

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“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

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Section: Systematic Literature Reviewmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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“…Ameloblastic fibrosarcoma is a locally aggressive, rare malignant odontogenic tumor [1][2][3][4]. It represents <5% of all odontogenic tumors [2,4].…”

Section: Commentsmentioning

confidence: 99%

“…It represents <5% of all odontogenic tumors [2,4]. In 2015, only 72 cases were reported in English literature [2].…”

Section: Commentsmentioning

confidence: 99%

“…It represents <5% of all odontogenic tumors [2,4]. In 2015, only 72 cases were reported in English literature [2]. Ameloblastic fibrosarcoma most often occurs in patients around 30 years of age [1], but reported cases include those of patients ranging from 4 months to 78 years of age.…”

Section: Commentsmentioning

confidence: 99%

“…Ameloblastic fibrosarcoma most often occurs in patients around 30 years of age [1], but reported cases include those of patients ranging from 4 months to 78 years of age. It is most common in the mandible (79% cases [4]), predominantly in its posterior part [2,5].…”

Section: Commentsmentioning

confidence: 99%

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Ameloblastic fibrosarcoma of the mandible: case report and literature review

Hascoët¹,

Cléac'h²,

Taugeron³

et al. 2017

Med Buccale Chir Buccale

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--Introduction: Ameloblastic fibrosarcoma is a rare malignant odontogenic tumor. Over 50% reported cases have histological evidence of ameloblastic fibroma at the same site. The mortality rate of the tumor is 19% and its recurrence rate is 37%, which mandates a total resection along with long-term follow-up. Observation: We present the case of a 14-year-old male diagnosed with ameloblastic fibrosarcoma, who underwent multiple stages of treatments and was followed up over 8 years. The initial management consisted of a total tumor resection with chemoradiotherapy. Then, for bone, soft, mucosal, and dental restoration after resection, mandibular reconstruction with a fibula free flap, onlay iliac graft, iliac graft fixation, facial lipofilling treatments (two), vestibular deepening procedures (two), and implant-supported dental prosthesis were performed. Comments and conclusion: This is the first case reported in the literature for the global management of mandibular ameloblastic fibrosarcoma, from oncological treatment to functional and aesthetic long-term rehabilitation.

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Successful treatment of a rare case of ameloblastic fibrosarcoma with radiation therapy

et al. 2017

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Sarcomas are rare diseases of the head and neck region, representing around 1% of all malignancies. Amongst them, ameloblastic fibrosarcoma (AFS) is of even greater rarity, with less than 100 cases reported in the literature. Consequently, no standard treatment or guidelines have been made available. Surgery is often performed as primary therapy, but may be limited due to anatomical or functional reasons. We present a case of AFS successfully treated by postoperative radiation therapy. A detailed case study is provided, followed by a review of the English-language literature focusing on the role of radiation therapy.

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Ameloblastic Fibrosarcoma of the Mandible: A Case Report and a Review of the Literature

Cited by 13 publications

References 24 publications

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Ameloblastic fibrosarcoma of the mandible: case report and literature review

Successful treatment of a rare case of ameloblastic fibrosarcoma with radiation therapy

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