Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver

El-Shenawy, Nahla S.; El-Salmy, Fawzia; Al-Eisa, Rasha A.; El-Ahmary, Bedor

doi:10.1016/j.pestbp.2009.09.008

Cited by 87 publications

(64 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…01 for all tested parameters). These results are supported by previous biochemical studies that showed alteration of such biomarkers in experimental animals and humans exposed to organophosphorus insecticides, profenofos (51,53) , fenitrothion (54,55) , chlorpyrifos (56) and diazinon (57) . Co-administration of water extract of cinnamon to profenofos treated rats (group 4) daily for 30 days along with profenofos residues greatly prevented the deviation in the liver function indices in relation to profenofos residues treated rats (group 3).…”

Section: Toxicological Studies Effect On Cholinesterase Activitysupporting

confidence: 89%

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

2011

Egypt. J. Chem.

View full text Add to dashboard Cite

Section: Toxicological Studies Effect On Cholinesterase Activitysupporting

confidence: 89%

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

2011

Egypt. J. Chem.

View full text Add to dashboard Cite

“…It has been shown that the levels of lipoperoxidation are elevated in rat heart tissue poisoned with the pesticide phosphine, and that this compound and its derivatives can produce an increment in the levels of lipid peroxidation in the rat brain, lung and liver (Hsu et al, 2002;El-Shenawy et al, 2010). Additionally, direct sperm damage has been verified in Eisenia foetida (earth red worm) when exposed to organophosphates (Espinoza-Navarro & Bustos-Obregón, 2005); in those experiments, when melatonin was added simultaneously to the terrarium, the sperm damage was totally prevented for low pesticide concentrations or severely diminished for high concentrations of diazinon (BustosObregón et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon

et al. 2011

View full text Add to dashboard Cite

SUMMARY:Since normal sperm parameters can be altered by organophosphorous pesticides, this study intended to determine if melatonin is able to prevent the damage on sperm quality after an acute exposure to diazinon. Adult male mice were injected intraperitoneally with melatonin, diazinon (1/3 or 2/3 LD50) or both, and sperm parameters were evaluated on days 1 or 32 post injection. Groups treated with diazinon showed elevated lipid peroxidation levels on day 1 post treatment, while groups pretreated with melatonin before diazinon showed no difference compared to control. Sperm count showed a significant decrease in both diazinontreated groups only on day 32 post injection; no differences were observed in groups pretreated with melatonin prior to diazinon compared to control. The percentage of abnormal sperm morphology increased in the diazinon-treated groups only on day 32 postinjection. The administration of melatonin prior to exposure to diazinon prevents the alteration of sperm parameters commonly caused by organophosphates, possibly due to its antioxidant properties.

show abstract

“…In recent years, some agents with antioxidant effects (e.g. vitamins C and E, N-acetylcysteine and zinc) have been used to decrease cellular oxidative stress and thus cellular damage, in cases of organophosphate poisoning [18,25]. Tert-butylhydroquinone (TBHQ) is one of the few antioxidants permitted for use in foods.…”

Section: Discussionmentioning

confidence: 99%

“…The severity of diazinon-induced lipid peroxidation in different tissues depends on several factors such as oxygen consumption, metabolic activity rate and susceptibility to oxidants [29]. The use of antioxidants has been suggested as one of the methods of dealing with the toxicity of organophosphates in various studies [18,25,26,31]. TBHQ is a derivative of hydroquinone, substituted with tert-butyl group.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Tert Butyl Hydroquinone on Diazinon-Induced Oxidative Stress in Brain and Heart of Male Rats

Sargazi

Moghadam-Jafari

Heidarpour

2016

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: The present study was designed to investigate the chronic effects of diazinon on oxidative stress markers in brain and heart of rats and the possible protective effects of tert butyl hydroquinone (TBHQ), as an antioxidant. Objectives: Therefore, the present study was undertaken to evaluate the protective role of TBHQ on oxidative stress induced by diazinon in brain and heart tissues of rats after 7 weeks exposure to sub-lethal dose of diazinon. Materials and Methods:In this experimental study, 28 male Wistar rats which were randomly divided into four groups: diazinon group (10 mg/kg, once a day), TBHQ group (0.028 g/kg of diet, once a day), diazinon + TBHQ group (diazinon, 10 mg/kg, once a day + TBHQ , 0.028 g/kg of diet, once a day) and control group (corn oil, as vehicle of diazinon and TBHQ). The animals were treated with diazinon, TBHQ or corn oil orally using a stomach tube for 7 weeks. Results: At the end of 7th week, total thiol groups, ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA) levels in brain and heart tissues were investigated. A significant increase in MDA levels (P = 0.01) in heart tissue was evident in diazinon group, when compared to control group. Rats of the TBHQ and diazinon + TBHQ groups presented a significant increase in thiol groups (P = 0.01), when compared to control and diazinon groups. In addition, TBHQ administration significantly increased the FRAP level of brain tissue in TBHQ and TBHQ + diazinon groups, when compared with control and diazinon groups, respectively (P = 0.001). Conclusions:The results of the present study showed that TBHQ treatment could improve antioxidant status in brain and heart tissues of rats with chronic toxicity of diazinon. However, it could not ameliorate the lipid peroxidation sufficiently.

show abstract

Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver

Cited by 87 publications

References 50 publications

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

Fate of 14C-ethyl Profenofos in Soybean Seeds and Oils, Residue Removal, Bioavailability, Toxicity and Protective Action of Cinnamon Extract towards Experimental Animals

Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon

Protective Effect of Tert Butyl Hydroquinone on Diazinon-Induced Oxidative Stress in Brain and Heart of Male Rats

Contact Info

Product

Resources

About