Ameliorative impact of cinnamon against high blood pressure; an updated review

Mahmoodnia, Leila; Aghadavod, Esmat; Rafieian-Kopaei, Mahmoud

doi:10.15171/jrip.2017.33

Cited by 15 publications

(9 citation statements)

References 44 publications

(53 reference statements)

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“…Cinnamomum zeylanicum (Family Lauraceae) which is commonly known as Ceylon cinnamon or true cinnamon is an indigenous plant in Sri Lanka. Recent studies have shown many beneficial health effects of Cinnamon such as anti-hypertensive effect, anti-inflammatory properties, anti-microbial activity, blood glucose control, reducing the risk of cardiovascular disease and colonic cancer ( Mahmoodnia, Aghadavod & Rafieian-Kopaei, 2017 ; Ouattara et al, 1997 ; Khan et al, 2003 ; Shen et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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Background Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and Discussion Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Section: Introductionmentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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“…This interest has grown exponentially in developing TCM therapeutic agents and their bioactive compounds as an alternate therapy for DM ( William et al, 2019 ). Studies have shown that cinnamon has many beneficial health effects, including hypolipidemic, hypotensive, anti-inflammatory, antimicrobial, hypoglycemic, and neuroprotective activities, some of which are closely related to the prognosis and development of DM ( Kwon et al, 2009 ; Nabavi et al, 2015 ; Mahmoodnia et al, 2017 ; Shang et al, 2021 ). The most common essential oil constituents of common identified in the literature include, cinnamaldehyde ( Subash Babu et al, 2007 ), eugenol ( Singh et al, 2016 ), beta-caryophyllene ( Stevens and Allred, 2022 ), and gallic acid ( Fernandes and Salgado, 2016 ), which may have major biological effects.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review

Zhou

Lei

et al. 2022

Front. Physiol.

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Background: Cinnamon is a spice used in cooking and in large quantities as a medical complement with hypoglycemic and lipid-lowering properties. The potential pharmacological mechanisms underlying cinnamon’s anti-diabetic properties and its active ingredients have not been adequately determined. The current meta-analysis aims to systematically review the potential pharmacological mechanisms underlying the hypoglycemic and hypolipidemic efficacy of cinnamon administration and summarize clinical recommendations of cinnamon and its active ingredients.Method: Relevant randomized clinical trials (RCTs) were identified through a literature search that spanned the years January 2005 to April 2022. Retrieve electronic databases including Web of Science, PubMed, Embase, Medline, and the Cochrane Library. To obtain standardized mean differences (SMDs), continuous outcomes were pooled and 95 percent confidence intervals (CIs) were provided. Categorical outcomes were aggregated to calculate relative risks (RRs) and were accompanied by 95% CIs. Heterogeneity was measured using the Cochrane Q-test and I2 statistics, with a p < 0.05 considered as substantial heterogeneity. If I2 was less than 50%, a fixed effect model was employed; otherwise, a random effect model was used. Subgroup analyses and sensitivity analyses were performed to identify the origins of heterogeneity. Publication bias was retrieved by means of a funnel-plot analysis and Egger’s test. The data were analyzed using revman (V.5.3) and stata (V.15) software packages.Results: These 16 RCTs included a total of 1,020 patients who were followed for a duration ranging from 40 days to 4 months. According to the current meta-analysis results, glycolipid levels in diabetic individuals who received cinnamon were significantly improved as compared to those who got placebo (All p < 0.05). An adverse effect was only detected in one patient.Conclusion: These findings imply that cinnamon has a significant influence on lipid and glucose metabolism regulation. An even more pronounced effect was observed in patients with HbA1c of 8%. The results of this study suggested that cinnamon may be utilized as hypoglycemic and lipid-lowering supplement in clinical settings with a guaranteed safety profile.Systematic Review Registration: [PROSPERO], identifier [CRD42022322735].

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“…1). In nature, they are commonly found as monomers or polymerized as proanthocyanidins, also known as condensed tannins (Andrés-Lacueva et al, 2009;Mahmoodnia, Aghadavod, & Rafieian-Kopaei, 2017). These compounds have been extensively studied and popularized by their presence in green tea and attributed antioxidant, anti-inflammatory, and anti-obesogenic properties (Johnson, Bryant, & Huntley, 2012;Suzuki, Pervin, Goto, Isemura, & Nakamura, 2016).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular protective effect of cinnamon and its major bioactive constituents: An update

Das

Gonçalves

Heredia

et al. 2022

Journal of Functional Foods

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Ameliorative impact of cinnamon against high blood pressure; an updated review

Cited by 15 publications

References 44 publications

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review

Cardiovascular protective effect of cinnamon and its major bioactive constituents: An update

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