Ameliorative Effects of Zinc Oxide, in Either Conventional or Nanoformulation, Against Bisphenol A Toxicity on Reproductive Performance, Oxidative Status, Gene Expression and Histopathology in Adult Male Rats

El-Kossi, Dina M. M. H.; Ibrahim, Shawky S.; Hassanin, Kamel M. A.; Hamad, Nashwa; Rashed, Noha A.; Abdel-Wahab, Ahmed

doi:10.1007/s12011-023-03830-w

Cited by 5 publications

(1 citation statement)

References 51 publications

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“…Zinc exerts an influence on the cellular redox status, mitigating oxidative stress and countering the activation of NF-κB signalling [54]. Given its importance for the function of various zinc finger proteins, some of which can interact with NF-κB, zinc can impact the activity and localization of NF-κB.…”

Section: Effect On Inflammationmentioning

confidence: 99%

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Briassoulis,

Ilia

et al. 2023

Antioxidants

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Zinc is a structural component of proteins, functions as a catalytic co-factor in DNA synthesis and transcription of hundreds of enzymes, and has a regulatory role in protein–DNA interactions of zinc-finger proteins. For many years, zinc has been acknowledged for its anti-oxidative and anti-inflammatory functions. Furthermore, zinc is a potent inhibitor of caspases-3, -7, and -8, modulating the caspase-controlled apoptosis and necroptosis. In recent years, the immunomodulatory role of zinc in sepsis and COVID-19 has been investigated. Both sepsis and COVID-19 are related to various regulated cell death (RCD) pathways, including apoptosis and necroptosis. Lack of zinc may have a negative effect on many immune functions, such as oxidative burst, cytokine production, chemotaxis, degranulation, phagocytosis, and RCD. While plasma zinc concentrations decline swiftly during both sepsis and COVID-19, this reduction is primarily attributed to a redistribution process associated with the inflammatory response. In this response, hepatic metallothionein production increases in reaction to cytokine release, which is linked to inflammation, and this protein effectively captures and stores zinc in the liver. Multiple regulatory mechanisms come into play, influencing the uptake of zinc, the binding of zinc to blood albumin and red blood cells, as well as the buffering and modulation of cytosolic zinc levels. Decreased zinc levels are associated with increasing severity of organ dysfunction, prolonged hospital stay and increased mortality in septic and COVID-19 patients. Results of recent studies focusing on these topics are summarized and discussed in this narrative review. Existing evidence currently does not support pharmacological zinc supplementation in patients with sepsis or COVID-19. Complementation and repletion should follow current guidelines for micronutrients in critically ill patients. Further research investigating the pharmacological mechanism of zinc in programmed cell death caused by invasive infections and its therapeutic potential in sepsis and COVID-19 could be worthwhile.

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Section: Effect On Inflammationmentioning

confidence: 99%

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Briassoulis,

Ilia

et al. 2023

Antioxidants

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Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms

Sahu,

Jena

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression

Cao,

Xu,

Liu

et al. 2023

Environ Sci Pollut Res

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Growing evidence suggests that exposure of Bisphenol A (BPA), an endocrine disruptor that commonly presence in the environment, can impair reproduction. However, con icting results have been reported and the underling mechanism have not been fully understood. In this study, 3 weeks old male mice were exposed to 50mg/kg/d BPA or equivalent corn oil for 28 days. Their testis and epididymis were then collected for morphology examination by HE stains. The number of sperm were counted, and the morphology was analyzed by PNA and pap staining. Fertilization capacity and successful rate was analyzed after mating with wide type females. Spermatid DNA damage and apoptosis were evaluated by DFI, γH2AX stain and TUNEL assay. RNA-seq analysis was conducted to identify differentially expressed genes in testicular tissue of mice exposed to BPA. RNA interference was used to verify the regulatory mechanism of BPA exposure on gene expression in GC-2 cells. Our data showed that total number of sperm was decreased and the morphology was impaired in BPA-exposed mice. In addition, the serum testosterone level and fertilization e ciency were also reduced. Mechanism studies showed that BPA could suppress the expression of PCBP2, a key regulatory gene in spermatid development, by activating the EZH2/H3K27me3. In conclusion, we found that BPA exposure can impair spermatid development via affecting key gene expression that at least partially due to epigenetic modi cation.

show abstract

Ameliorative Effects of Zinc Oxide, in Either Conventional or Nanoformulation, Against Bisphenol A Toxicity on Reproductive Performance, Oxidative Status, Gene Expression and Histopathology in Adult Male Rats

Cited by 5 publications

References 51 publications

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms

Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression

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