Ameliorative effects of Spirulina platensis against lead-induced nephrotoxicity in newborn rats: modulation of oxidative stress and histopathological changes

Soussi, Ahlem; Akrouti, Amel; Magné, Christian; A, El Feki

doi:10.17179/excli2017-1016

Cited by 11 publications

(3 citation statements)

References 57 publications

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“…When the maximum excretion of lead by the kidneys is reached, lead is deposited in the proximal tubule epithelial cells, affecting cell metabolism and damaging the structure and function of the kidneys. When cells are damaged or necrotic, renal tubular reabsorption function decreases, causing creatinine (CRE) and urea to remain in the blood, which resulting in an increase in blood creatinine and blood urea nitrogen concentration ( 32 ). Lead also inhibits the activity of δ-aminolevulinic acid dehydratase (δ-ALAD), which increases the ALA in the blood.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats

Long

Zhou

et al. 2022

Front. Nutr.

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Lead poisoning caused by lead pollution seriously affects people's health. Lactic acid bacteria has been shown to be useful for biological scavenging of lead. In this experiment, Sprague-Dawley (SD) rats were treated with 200 mg/L of lead acetate solution daily to induce chronic lead poisoning, and oral Limosilactobacillus fermentum (L. fermentum) SCHY34 to study its mitigation effects and mechanisms on rat neurotoxicity. The L. fermentum SCHY34 showed competent results on in vitro survival rate and the lead ion adsorption rate. Animal experiments showed that L. fermentum SCHY34 maintained the morphology of rat liver, kidney, and hippocampi, reduced the accumulation of lead in the blood, liver, kidney, and brain tissue. Further, L. fermentum SCHY34 alleviated the lead-induced decline in spatial memory and response capacity of SD rats, and also regulated the secretion of neurotransmitters and related enzyme activities in the brain tissue of rats, such as glutamate (Glu), monoamine oxidase (MAO), acetylcholinesterase (AchE), cyclic adenosine monophosphate (cAMP), and adenylate cyclase (AC). In addition, the expression of genes related to cognitive capacity, antioxidation, and anti-apoptotic in rat brain tissues were increased L. fermentum SCHY34 treatment, such as brain-derived neurotrophic factor (BDNF), c-fos, c-jun, superoxide dismutase (SOD)1/2, Nuclear factor erythroid 2-related factor 2 (Nrf2), and B-cell lymphoma 2 (Bcl-2), and so on. L. fermentum SCHY34 showed a great biological scavenging and potential effect on alleviating the toxicity of lead ions.

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Section: Discussionmentioning

confidence: 99%

Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats

Long

Zhou

et al. 2022

Front. Nutr.

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“…Arthrospira platensis exhibited a significant protective effect against lead-induced oxidative stress in the kidney of newborn rats and prevented oxidative damage induced by lead in the renal tissue [ 136 ]. The modulatory effect of Arthrospira platensis on lead toxicity may be due its high content of flavonoids which are powerful antioxidants, β-carotene, iron, γ-linolenic acid, other carotenoids, phycocyanins and vitamins [ 136 , 137 , 138 ]. Ebaid et al demonstrated the protective effects of Arthrospira platensis against nano-CuO-induced hepatotoxicity in albino rats [ 138 ].…”

Section: Medical Application Of Arthrospira Platensismentioning

confidence: 99%

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature

Gentscheva

Nikolova

Panayotova

et al. 2023

Life

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Arthrospira platensis is a filamentous cyanobacterium of the class Cyanophyceae and is the most cultivated photosynthetic prokaryote. It is used in the pharmaceutical sector, medicine and the food industry. It has a rich micro- and macro-element composition, containing proteins, lipids, carbohydrates, essential amino acids, polyunsaturated fatty acids, minerals and raw fibers. It is a commonly used ingredient in food products and nutritional supplements. The wide range of biologically active components determines its diverse pharmacological properties (antioxidant, antidiabetic, antimicrobial, antineoplastic, antitumor, anti-inflammatory, photoprotective, antiviral, etc.). This review summarizes research related to the taxonomy, distribution and chemical composition of Arthrospira platensis as well as its potential application in the food and pharmaceutical industries. Attention is drawn to its various medical applications as an antidiabetic and antiobesity agent, with hepatoprotective, antitumor, antimicrobial and antiviral effects as well as regulatory effects on neurodegenerative diseases.

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“…When the maximum excretion of lead by the kidneys is reached, lead is deposited in the proximal tubule epithelial cells, affecting cell metabolism and damaging the structure and function of the kidneys. When cells are damaged or necrotic, renal tubular reabsorption function decreases, causing creatinine (CRE) and urea to remain in the blood, which resulting in an increase in blood creatinine and blood urea nitrogen concentration (32). Lead also inhibits the activity of δaminolevulinic acid dehydratase (δ-ALAD), which increases the ALA in the blood.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effects of Spirulina platensis against lead-induced nephrotoxicity in newborn rats: modulation of oxidative stress and histopathological changes

Cited by 11 publications

References 57 publications

Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats

Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature

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