Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats

Abstract

BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats.MethodsFemale Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Metformin was also given as a standard control to one of the rat groups.Serum estradiol, progesterone, testosterone, serum lipid parameters, CRP and glucose levels were evaluated. Furthermore, antioxidant activity was tested using superoxide dismutase, catalase, glutathione per-oxidase and reactive-oxygen species level.ResultsRutin flavonoid had a dose-dependent effect on androgenic levels depicting more recovery in the rutin-I treated group, while rutin-II treated groups showed better antioxidant and lipid profiles as compared with PCOS groups. A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups. Histopathological examination of ovary revealed a significant decrease in the number of cystic follicles in post treated groups. The effects observed with rutin were moderately similar to that with standard metformin, a widely used treatment drug for PCOS.ConclusionThe study provides evidence for the potential ameliorative effects of rutin against clinical and biochemical features of PCOS.

Ameliorating effect of Brassica oleracea (broccoli) extract on the myocardial damage induced by polycystic ovary syndrome in the adult female albino rat

“…Our results reproduced the findings of previous studies where PCOS induced group showed significant increase in serum level of triglyceride (TG), total cholesterol (CH), low density lipoprotein (LDL) and significant decrease in high density lipoprotein (HDL) [35,36]. Previous studies [37,38] attributed imbalances in lipid profile in PCOS to hyperandrogenemia as confirmed in our study by the significant increase in the Figure 6.…”

Modulation of steroidogenesis by Actaea racemosa and vitamin C combination, in Letrozole induced polycystic ovarian syndrome rat model: Promising activity without the risk of hepatic adverse effect

“…Oxidative stress may be engaged in the pathogenesis of PCOS (47). Induced oxidative stress in ovaries by LTZ (48) was similar to that observed in natural PCOS (6). Our results indicated a significant increase in MDA level and reduction in GSH activity.…”

Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

“…The hormonal statistics of letrozole induced rats embodied a hyper-androgenized state responsible for abnormal ovarian physiology [ 18 ]. The disruption in usual hypothalamic pituitary gonadal axis, elevate both testosterone and LH and developed a disease state [ 57 , 58 ].…”

“…Currently, plant extracts are being widely used to treat female reproductive disorders [ 16 , 17 ]. Flavonoids are plant based compounds which are of great interest due to their expansive pharmacological activities [ 18 ]. Quercetin (3,5,7,3′,4′-pentahydroxyflavone) is a flavonoid [ 19 ], ubiquitously present in fruits and vegetables especially tomato, onion, broccoli, lettuce, grapes, apple and blueberries [ 20 ].…”