Ameliorative effects of Diammonium Glycyrrhizinate on inflammation in focal cerebral ischemic-reperfusion injury

Hou, Shaozhang; Yuan, Li; Zhu, Xiaolei; Wang, Zhongyuan; Wang, Xin; Xu, Yun

doi:10.1016/j.brainres.2012.02.011

Cited by 31 publications

(29 citation statements)

References 43 publications

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“…Studies have shown that acute neuroinflammatory processes are responsible for much of cerebral ischemic tissue injury [6,7]. Neutrophils are the earliest leukocytes to migrate to the ischemic focus.…”

Section: Discussionmentioning

confidence: 99%

“…The evolution of the glial response promotes the activation of pro-inflammatory transcription factors such as NF-kB (nuclear factor kappa B), with the subsequent expression of pro-inflammatory mediators such as TNF-α and iNOS in the ischemic region [6]. MCAO induces a significant increase in NF-kB, which in turn mediates the transcription of mRNA and an increase in TNF-α expression up to 7 days after the ischemic event [72].…”

Section: Discussionmentioning

confidence: 99%

“…Clearly, glutamate excitotoxicity, calcium overload, oxidative stress, inflammation and apoptosis are important contributing factors in the pathophysiology of cerebral ischemia [5]. Inflammation is responsible for much of cerebral ischemic tissue injury [6,7]. Together with microglia, astrocytes contribute to the production of inflammatory mediators, such as TNF-α and iNOS, which are triggered by pro-inflammatory genes, and NF-kB, which is driven by astrogliosis and microgliosis [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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“…Clinically, DG is widely used in the therapy of chronic hepatitis for its effects of inhibiting inflammatory reactions and ischemia-reperfusion injury. These effects have been demonstrated to be beneficial in rat models of ulcerative colitis and cerebral ischemia reperfusion (7,8). The present study focused on its effect on random skin flap survival in rats.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study in a model of ulcerative colitis indicated that DG was able to reduce inflammatory injury via suppression of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury (7). Furthermore, it was found that DG had neuroprotective potential against ischemia-reperfusion injury in a model of focal cerebral ischemic-reperfusion injury, and this effect was also likely associated with the anti-inflammatory function of DG according to a previous study (8). However, the protective role of DG in random skin flap survival has not, to the best of our knowledge, been clearly characterized.…”

Section: Introductionmentioning

confidence: 88%

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study

Gao

Lin

et al. 2016

Biomedical Reports

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Abstract. Partial necrosis of skin flaps continues to restrict the survival of local skin flaps following plastic and reconstructive surgeries. The aim of the present study was to investigate the effects of diammonium glycyrrhizinate (DG), a salt of glycyrrhetinic acid that has been widely used in the therapy of chronic hepatitis and human immunodeficiency virus infection, on random skin flap survival in rats. McFarlane flaps were established in 60 male Sprague-Dawley rats randomly divided into three groups. Group I served as the control group and was injected with saline (10 mg/kg) once per day. Group II and group III were the experimental groups, and were injected with 10 mg/kg DG once and twice per day, respectively. On day 7, the survival area of the flap was measured. Tissue samples were stained with hematoxylin and eosin and immunohistochemically evaluated. Tissue edema, neutrophil density, superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels were evaluated. The mean survival areas of the flaps of group II were significantly larger when compared with those of group I (P<0.05), and the rats of group III exhibited significantly higher survival areas than group II (P<0.05). Histologic and immunohistochemical evaluation showed that microvessel development and the expression level of vascular endothelial growth factor were higher in the two experimental groups than in the control group. Furthermore, SOD activity was significantly increased (P<0.05), while the neutrophil density and MDA level were significantly reduced (P<0.05) in group II when compared with group I. Significant differences between group II and group III with regard to SOD activity and MDA level were also observed (P<0.05). Thus, DG may have a dose-dependent effect on promoting the survival of random skin flaps.

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Hypoxic‐ischemic brain injury and narcotic drugs administration

Xiong

Zhou

et al. 2020

Ibrain

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Following cerebral ischemia and hypoxia, disorders in brain metabolism, histological pathology, and neural function commonly could result in different nerve injuries, to some degree. Many researchers have revealed that some narcotic drugs hold a prominent efect of prevention and therapy on cerebral ischemic-hypoxic injury and ischemia-reperfusion injury. However, the underlying mechanism is largely unknown. In this paper, we summarized narcotic drugs' roles in antagonizing the neurotoxicity of excitatory amino acid, reducing excitatory injury and activating intracellular signaling cascade channel, adjusting the balance of Ca 2+ , increasing the expression of protective genes, reducing the generation of NO and free radical and anti-lipid peroxidation, and discussed and elucidated their relations.

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Ameliorative effects of Diammonium Glycyrrhizinate on inflammation in focal cerebral ischemic-reperfusion injury

Cited by 31 publications

References 43 publications

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study

Hypoxic‐ischemic brain injury and narcotic drugs administration

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