Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats

Hagar, Hanan; Medany, Azza El; Eter, Eman El; Arafa, Maha

doi:10.1016/j.ejphar.2006.09.066

Cited by 94 publications

(82 citation statements)

References 53 publications

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“…It is well studied that depletion of GSH leads to the cellular damages. Depleted GSH is characteristic feature of colonic injury [25] . HRS restores the reduced levels of SOD and GSH.…”

Section: Discussionmentioning

confidence: 99%

“…But, this oxidation is not specific and do not affect any cell molecule. Increase in NO level is the result of tissue toxicity caused by damage of colonic mucosa [25,26] . It also reacts with SOD and other oxidative biomarkers to precipitate tissue damage.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-毩 is a major proinflammatory cytokines responsible for migration of NF-毷B into the nucleus of the mucosal cells [28] . It instigates a cascade which involves overproduction of other proinflammatory cytokines and adhesion molecule leading to further damage of colonic mucosa [25,29] . HRS administration reduced TNF -毩, proving it's potential as antioxidant and NF-毷 B inhibitor.…”

Section: Discussionmentioning

confidence: 99%

“…MPO activity was defined as the quantity of enzyme degrading 1 毺 mol of peroxide per min at 25 曟 and was expressed in units per gram (U/gm) of wet scrapings.…”

Section: Determination Of Colonic Mpo Contentsmentioning

confidence: 99%

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Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats

Kandhare

Raygude

Ghosh

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…It is well studied that depletion of GSH leads to the cellular damages. Depleted GSH is characteristic feature of colonic injury [25] . HRS restores the reduced levels of SOD and GSH.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…MPO activity was defined as the quantity of enzyme degrading 1 毺 mol of peroxide per min at 25 曟 and was expressed in units per gram (U/gm) of wet scrapings.…”

Section: Determination Of Colonic Mpo Contentsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats

Kandhare

Raygude

Ghosh

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…Serum Lactate Dehydrogenase (LDH) 16 The serum was used for determination of LDH, indicator of tissue damage by using commercially available diagnostic kit (ERBA Diagnostics, Mannhim GmbH, Germany).…”

Section: Biochemical Assaysmentioning

confidence: 99%

Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats

Patil¹,

Rasal²,

Malabade³

2014

IJPER

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Protective effect of curcumin, a Curcuma longa constituent, in early colonic inflammation in rats

Sánchez-Calvo

Villegas

Sánchez-Fidalgo

et al. 2009

Drug Development Research

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Curcumin, a polyphenol derived from the plant, Curcuma longa, has a variety of pharmacological effects, including chemotherapeutic, anti-inflammatory, antiangiogenic, and antioxidant activities. To gain a better understanding of the effects and mechanisms of action of curcumin on the acute injury caused by intra-colonic administration of acetic acid (AA) in rats, inflammation was assessed by histology and myeloperoxidase activity (MPO; an index of neutrophil infiltration in the mucosa); Th1 and Th2 cytokine production; histological and histochemical analysis of the lesions; nitrite production in colon mucosa; and the expression of iNOS, COX-1 and -2 using Western blotting and inmmunohistochemistry. We also studied the involvement of the p38 MAPK/JNK signalling pathway in the protective effect of curcumin in acute colonic inflammation. Curcumin (50-100 mg/kg/day) reduced the degree of colonic injury, the index of neutrophil infiltration and Th1 cytokine secretion, and increased IL-10 production, reduced colonic levels of nitrites, and reduced COX-2 and iNOS overexpression. A reduction in the activation of p38 and JNK MAPKs was also observed. Thus, we show that the widely used food additive, curcumin reduced the development of AA-induced colitis and alleviated the inflammatory response. Inhibition of MAPK signalling by curcumin could explain the changes on the cytokine Th1/Th2 profile, the reduction of COX-2 and iNOS signaling, as well as the decreased nitrite production in colonic mucosa, suggesting that curcumin may be useful in the treatment of ulcerative colitis. Drug Dev Res 70 : 425-437, 2009.

show abstract

Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats

Cited by 94 publications

References 53 publications

Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats

Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats

Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats

Protective effect of curcumin, a Curcuma longa constituent, in early colonic inflammation in rats

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