Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats

Patil, Nitin R.; Rasal, Vijaykumar P.; Malabade, Rohit

doi:10.5530/ijper.48.4s.1

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…In contrast, other studies, especially in vivo studies, assessed the anti-inflammatory activity and at the end of the experiment the animals were euthanized and blood collected for serum levels indicating enzymes of oxidative stress. In these models, the analyses of superoxide dismutase, catalase, glutathione, malondialdehyde, and lipid peroxidation were mostly described [25, 26, 32, 35, 36, 39, 46, 47, 49].…”

Section: Resultsmentioning

confidence: 99%

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Lavor

Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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Inflammatory diseases result from the body's response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases. Due to the complexity of events that occur in inflammation associated with the adverse effects of drugs used in clinical practice, it is necessary to search for new biologically active compounds with anti-inflammatory activity. Among natural products, essential oils (EOs) present promising results in preclinical studies, with action in the main mechanisms involved in the pathology of inflammation. The present systematic review summarizes the pharmacological effects of EOs and their compounds in in vitro and in vivo models for inflammation. The research was conducted in the following databases: PubMed, Scopus, BIREME, Scielo, Open Grey, and Science Direct. Based on the inclusion criteria, 30 articles were selected and discussed in this review. The studies listed revealed a potential activity of EOs and their compounds for the treatment of inflammatory diseases, especially in chronic inflammatory conditions, with the main mechanism involving reduction of reactive oxygen and nitrogen species associated with an elevation of antioxidant enzymes as well as the reduction of the nuclear factor kappa B (NF-κB), reducing the expression of proinflammatory cytokines. Thus, this review suggests that EOs and their major compounds are promising tools for the treatment of chronic inflammation.

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Section: Resultsmentioning

confidence: 99%

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Lavor

Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Treatments started after 2 h of TNBS administration and continued daily for 7 days. Animals were sacrificed to remove colon for histopathology, macroscopic scoring and biochemical assay [11,12].…”

Section: Experimental Protocolmentioning

confidence: 99%

Anti-Inflammatory Effect of Neuracanthus Sphaerostachyus Dalz. Leaves on Experimental Colitis in Rats

Dk¹,

Patel²

2021

IGJPS

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“…The animals were sacrificed and the colon was excised and opened longitudinally. Macroscopic scoring was done using the following score criteria, 0 -No change in both mucosa and serosa, 1-Petechial bleeding and hyperemia, 2-single mucosal erosion or ulceration, 3-single mucosal erosion or ulcer with hyperemic, adhesive, or hemorrhagic lesions in the serosa and mesentery, 4-multiple erosions or ulcerations (less than 10 cm) and 5-Multiple erosions or ulcerations (more than 10 cm) [15].…”

Section: Assessment Of Macroscopic Charactersmentioning

confidence: 99%

“…One unit of MPO activity is defined as the change in absorbance per minute by 1.0 at room temperature in the final reaction. MPO activity is calculated by � � = ℎ ℎ Where X = 10 X changes in absorbance per minute / Volume of supernatant taken in the final reaction [15].…”

Section: Estimation Of Colonic Mpo Levelmentioning

confidence: 99%

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Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats

Padmavathi

Keerthana

Devi

et al. 2021

JOAPR

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The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid-induced ulcerative colitis in Wistar rats. Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group -I, Sham control, administered a single dose of vehicle rectally; Group -II, colitis control, colitis was induced by rectal administration of a single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group-III, treated with Turmeric (50 mg/kg/p.o); Group-IV, treated with Bromelain (100 mg/kg/p.o) and Group -V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on the first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on the 8 th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on the 9 th day, all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and, Histopathology. Results obtained were analyzed by one-way analysis of variance followed by Tukey's multiple comparison test. Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and, MPO have shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. Conclusion: The present study recommends that the combination of Turmeric and Bromelain has a synergistic effect in treating ulcerative colitis.

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Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats

Cited by 6 publications

References 13 publications

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Anti-Inflammatory Effect of Neuracanthus Sphaerostachyus Dalz. Leaves on Experimental Colitis in Rats

Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats

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