Ameliorative effect of Myristica fragrans (nutmeg) extract on oxidative status and histology of pancreas in alloxan induced diabetic rats

Pashapoor, Afsaneh; Mashhadyrafie, Seeyamak; Mortazavi, Pejman

doi:10.5603/fm.a2019.0052

Cited by 13 publications

(13 citation statements)

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“…This significant alleviation may also depend on other factors such as dose and intervention duration. Meanwhile, the administration of nutmeg seed extract (using petroleum ether) at 50 mg/kg bw for 16 weeks suppressed FBG in male diabetic Wistar rats up to 7.9%, and higher reduction at 45.06% and 55.57% was acquired at 100 mg/kg bw and 200 mg/kg bw, respectively (Pashapoor et al, 2020). Another research reported that FBG in T2DM Wistar rats treated with petroleum ether extract of nutmeg seed was significantly reduced at dose 200 mg/kg bw, but such effect was insignificant at dose of 50 and 100 mg/kg (Somani & Singhai, 2008).…”

Section: Effect Of Nutmeg On Fbgmentioning

confidence: 97%

“…The intervention of male tipe 2 DM Wistar rats by safrole-free extract of M. fragrans Houtt seed (5.4 mg/200 g bw) for 2, 4, and 6 days could reduce FBG at lower rate than that treated with pioglitazone (0.54 mg/200 g bw) and fenofibrate (3.6 mg/200 g bw) (Lestari et al, 2019). FBG was also lower in male hyperglycemic rats treated with methanolic extract of M. fragrans seed at concentration of 125, 250, and 500 mg/kg bw for 6 days than those treated pioglitazone at concentration of 2.7 and 10 mg/kg bw (Lestari et al, 2012) higher than positive control, showing the difference by <40.25%, even reaching up to <6.59% (Somani & Singhai, 2008;Kareem et al, 2009;Eo & Ie, 2020;Pashapoor et al, 2020). These evidences clearly support the antidiabetic potential of nutmeg, which can be comparable to standard antidiabetic drugs.…”

Section: Effect Of Nutmeg On Fbgmentioning

confidence: 99%

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Effect of nutmeg on glycemic status in rat and mice: a systematic review

et al. 2023

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Glycemic status depicts a state of individual blood glucose level. Biochemical parameters to identify glycemic status associated with diabetes mellitus include fasting or non-fasting blood glucose, HbA1c, and oral glucose tolerance. Our present work conducted a systematic review aiming to systematically summarize the in vivo experimental results of nutmeg treatments towards the glycemic status of rats and mice. The systematic review followed PRISMA guidelines. PubMed, ProQuest, Wiley Online Library, and Google Scholar were used as databases for searching articles. Twenty-one articles that met the criteria were eventually used in this systematic review. The results of the in vivo studies revealed that the intervention of nutmeg samples in rats and mice had a positive effect. This finding was present in all reviewed articles. Overall, treatment by nutmeg samples was able to attenuate fasting blood glucose, non-fasting blood glucose, and HbA1c in rats and mice, reaching up to 94.52, 60.76, and 48.86%. We also found that nutmeg samples prepared from mace and methanol had the highest effect in reducing blood glucose. Based on this systematic review, it can be concluded that nutmeg has a positive effect on improving glycemic status and reducing the risk of DM in rats and mice.

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Section: Effect Of Nutmeg On Fbgmentioning

confidence: 97%

Section: Effect Of Nutmeg On Fbgmentioning

confidence: 99%

Effect of nutmeg on glycemic status in rat and mice: a systematic review

et al. 2023

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“…The possibility that combined spices may be synergistic in effect may be due to their mechanism of action. For example, ginger increases the uptake of glucose by body cells in an insulin-independent way (4), Ethiopian pepper activates the beta cells of the pancreas [7] and nutmeg repairs damaged beta cells of the pancreas [19]. Each spice would have a separate effect that would culminate in the observed antidiabetic outcome.…”

Section: Syntheticmentioning

confidence: 99%

“…The ethanol extract of Ethiopian pepper fruits was also shown to significantly reduce triglycerides, total cholesterol, and postprandial glycemia in insulin resistant rats [7]. Ethanol extract of black pepper to a larger extent lowered the levels of glucose in rats induced with alloxan [24] while Pashapoor et al [19] reported the dose-dependent regenerative effect of the petroleum ether extract of nutmeg on damaged pancreatic beta cells in diabetic Wistar rats. Furthermore, the ethanol extract of garlic reduced blood glucose in albino rats [25].…”

Section: Syntheticmentioning

confidence: 99%

In vitro comparative assessment of the inhibitory effects of single and combined spices against glucose-synthesizing enzymes

Adeyeoluwa¹,

Balogun²,

Ashafa³

2020

Trop. J. Pharm Res

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Purpose: To assess the individual and synergistic inhibitory activities of five (5) tropical spices, viz, Zingiber officinale Rosc., Xylopia aethiopica (Dun.) A. Rich, Piper guineense Schum & Thonn, Myristica fragrans Houtt. and Allium sativum L. against glucose hydrolysing enzymes.Methods: In vitro assessment of the alpha-amylase and alpha-glucosidase inhibitory activities of cold water, hot water, ethanol and aqueous-ethanol extracts of each of the five spices and their combination was investigated using enzymatic protocols. Acarbose was used as the standard.Results: Only four extracts showed strong inhibition against alpha-glucosidase and weak inhibition against alpha-amylase. Going by their half-maximal inhibitory concentrations (IC50), the combined spices exhibited the best concurrent inhibitory activity against both hydrolysing enzymes (665.83 ± 27.50 μg/mL for alpha-glucosidase) and (1166.86 ± 14.70 μg/mL for alpha-amylase).Conclusion: The findings from this study demonstrate the enhanced antihyperglycemic potentials of the combined spices compared to the individual spices for the management of diabetes. Keywords: Hyperglycemia, Diabetes, Alpha-amylase, Alpha-glucosidase, Zingiber officinale, Xylopia aethiopica, Piper guineense, Myristica fragrans, Allium sativum, Spices

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“… 2020 ) and antidiabetic effects (Pashapoor et al. 2020 ). Myristicin, a natural compound in nutmeg, has been reported to have a good therapeutic effect in liver injury.…”

Section: Introductionmentioning

confidence: 99%

Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway

Luo

Liang

Liu

2021

Pharmaceutical Biology

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Context Atherosclerosis (AS) is a chronic inflammatory disease. Human vascular smooth muscle cell (hVSMC) accumulation and human umbilical vein endothelial cell (HUVEC) dysfunction are associated with the pathogenesis of AS. This study explores whether myristicin plays a protective role in AS. Materials and methods hVSMCs and HUVECs were stimulated with 100 μg/mL oxidized low-density lipoprotein (ox-LDL) to establish a cellular model of AS. Cell viability, lactate dehydrogenase (LDH) release and cell apoptosis were evaluated using MTT, LDH and flow cytometry assays, respectively. Cell migration and inflammatory cytokine release were assessed using Transwell assay and ELISA. Results Myristicin (5, 10, 25, and 50 μM) had no obvious effect on cell viability or the activity of LDH in hVSMCs, while 100 and 200 μM myristicin markedly suppressed hVSMCs viability and increased LDH release. Myristicin had no obvious effect on cell viability or the activity of LDH in HUVECs. Myristicin inhibited viability and increased apoptosis in ox-LDL-treated hVSMCs, but was associated with increased proliferation and inhibited apoptosis in HUVECs stimulated by ox-LDL. Additionally, myristicin markedly suppressed ox-LDL-induced hVSMCs migration and the release of inflammatory cytokines, including MCP-1, IL-6, VCAM-1 and ICAM-1, in HUVECs. Results also demonstrated that the promoting effects of ox-LDL on the PI3K/Akt and NF-κB signalling pathway in both hVSMCs and HUVECs were abolished by treatment with myristicin. Discussion and conclusions Myristicin regulated proliferation and apoptosis by regulating the PI3K/Akt/NF-κB signalling pathway in ox-LDL-stimulated hVSMCs and HUVECs. Thus, myristicin may be used as a new potential drug for AS treatment.

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Ameliorative effect of Myristica fragrans (nutmeg) extract on oxidative status and histology of pancreas in alloxan induced diabetic rats

Cited by 13 publications

References 0 publications

Effect of nutmeg on glycemic status in rat and mice: a systematic review

Effect of nutmeg on glycemic status in rat and mice: a systematic review

In vitro comparative assessment of the inhibitory effects of single and combined spices against glucose-synthesizing enzymes

Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway

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