Ameliorative Effect of Mannan Oligosaccharide on Pathology of Fowl Cholera in Broiler Birds

Sonone, Swapnil; Swamy, Madhu; Verma, Yamini

doi:10.3923/ajpsaj.2011.86.93

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Within 24 h post- P. multocida infection, birds in the control groups showed mild to moderate signs with mortality which increased in severity till about 92 h post infection. A similar trend was reported in experimental birds challenged with P. multocida 25 , 47 , 48 . Depending on the strain, the incubation period of P. multocida usually varied between 12 and 48 h with 100% mortality majorly between 24 and 72 h post infection 49 .…”

Section: Discussionsupporting

confidence: 87%

“…The dietary inclusion of probiotics positively influenced haematopoiesis which among others increase the WBC counts, hence enhancing immune cells synthesis which further protects the host against invading pathogens 59,60 . The presence of congested blood vessels and haemorrhages observed in the lungs, livers, hearts and intestines of P. multocida infected birds as a result of fowl cholera is similar to the findings of Shivachandra et al and Sonone et al 9,48 . The supplementation of probiotics as revealed in this study significantly reduced the severity of P. multocida infection throughout the experiment, hence, reflecting in the improved haematological parameters as clearly shown.…”

Section: Anti-inflammatory Genesupporting

confidence: 88%

“…The reduction in major haematological parameters including Hb, PCV, ESR and total RBC in P. multocida challenged control groups clearly depicts the onset of anaemia. The occurrence of anaemia in avian cholera infection in poultry has been properly reported 48 . The cause of anaemia in P. multocida challenged birds as recorded in this study may be attributed to bacterial septicaemia.…”

Section: Discussionmentioning

confidence: 99%

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Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Reuben

Sarkar²,

Ibnat³

et al. 2021

Sci Rep

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Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.

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Section: Discussionsupporting

confidence: 87%

Section: Anti-inflammatory Genesupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Reuben

Sarkar²,

Ibnat³

et al. 2021

Sci Rep

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“…Dietary MOS has been used to bind pathogens with a mannose -specific Type 1 fimbrae therefore preventing the bound bacteria from colonizing the intestine and allowing them to pass through the intestine and be excreted [15,16]. This has resulted in the use of MOS to reduce the incidence and severity of infections of salmonella [17] and Pasteurella multocida in broilers [18].…”

Section: Introductionmentioning

confidence: 99%

Field Observations on the Effect of a Mannan Oligosaccharide on Mortality and Intestinal Integrity of Sole (Solea senegalensis, Kaup) Infected by Photobacterium damselae subsp. piscicida

Dimitroglou¹,

Moate²,

Janssens³

2011

J Aquac Res Development

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This study was conducted in order to investigate the effect of a mannan oligosaccharide (MOS) on the intestinal morphology of sole (Solea senegalensis, Kaup) reared under commercial conditions. The dietary inclusion rate for MOS was 0.4% and it was used either alone or in combination with a vaccination regime against bacterial diseases (Pasteurella spp. and Vibrio spp.). One week after the start of the experimental period, a natural outbreak of pasteurellosis, caused by Photobacterium damselae subsp.piscicida,occurred in all the groups of fish.A two-way ANOVA showed that only MOS supplementation reduced fish mortality by ca. 8% (P = 0.050). Additionally, light microscopy examination of the intestine revealed that MOS supplementation significantly increased the mucosal folding by 29% (P = 0.016) in the anterior intestinal region and by 33% (P = 0.002) in the posterior intestinal region. Scanning electron microscopy demonstrated that both MOS supplementation and vaccination significantly increased microvilli density on the enterocyte surfaces in the anterior intestinal regionby 13% (P = 0.028) and 30% (P = 0.001) respectively. In the posterior intestinal region neither MOS supplementation nor vaccination significantly affected the microvilli density (P = 0.005).The present study suggests that dietary MOS supplementation protects the intestinal morphology of infected sole and hinders the development of pathogenic infection, possibly by binding with Photobacterium damselae subsp. piscicida, resulting in reduced mortality of infected fish.

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Ameliorative Effect of Mannan Oligosaccharide on Pathology of Fowl Cholera in Broiler Birds

Cited by 2 publications

References 6 publications

Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Field Observations on the Effect of a Mannan Oligosaccharide on Mortality and Intestinal Integrity of Sole (Solea senegalensis, Kaup) Infected by Photobacterium damselae subsp. piscicida

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