Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patient

Abstract

Background: Nephrotoxicity is one of the most important limitations of cisplatin-based chemotherapies which associated with many complications and high mortality rate. Objectives: To investigate the effect of lycopene on cisplatin-induced nephrotoxicity in patients with cancer. Patients and Methods: In this double-blind, randomized clinical trial, 120 patients were randomly assigned to two groups, case (treated with lycopene + standard regimen of kidney injury prevention) and control (treated with only the standard regimen of kidney injury prevention). Lycopene was orally taken from 24 hours before to 72 hours after cisplatin administration. Blood urea nitrogen (BUN), serum creatinine (Cr), and glomerular filtration rate (GFR) were measured and recorded. The data were analyzed using SPSS. Results: Changes in Cr were not significantly different between the two groups (P = 0.131). However, a significant decreasing trend was seen in GFR during the study, which was more marked in the control group (P = 0.004). BUN significantly decreased during the study (P = 0.002), and a significant decrease of BUN on the day three in both groups was seen (P = 0.001). However, BUN increased in the case group on the day 21 of treatment. The corresponding increase was less marked in the control group. Conclusions: Lycopene can be considered a useful adjuvant therapy to decrease the complications due to cisplatin-induced nephrotoxicity in patients with cancer.

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

“…There are a number of recently published clinical trials and metaanalysis data revealing beneficial health effects of lycopene (Cicero & Colletti, 2015;Mahmoodnia, Mohammadi, & Masumi, 2017;Singh & Bagewadi, 2017;van Die et al, 2016). However, only few of them (Graff et al, 2017;Zhu, Gertz, Cai, & Burri, 2016) adequately address the issue of lycopene bioavailability in volunteers.…”

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

“…Nephrotoxicity is one of the most serious problem that hinders cisplatin-based chemotherapy (Mahmoodnia et al, 2017 ). In 2016, Shreesh Ojha et al provide a review summarized plant-derived natural products for counteracting cisplatin-induced nephrotoxicity (Ojha et al, 2016 ).…”

“…Lycopene has anti-oxidative effect. The results from a double-blind, randomized clinical trial show that lycopene is a useful adjuvant therapy, because its oral administration from 24 to 72 h after cisplatin administration can relief the complication of nephrotoxicity in cancer patients (Mahmoodnia et al, 2017 ). Hesperetin, a naturally-occurring bioflavonoid, protects against hydrogen peroxide-triggered oxidative damage via upregulation of Keap1-Nrf2/HO-1 pathway in ARPE-19 cells (Zhu et al, 2017 ).…”

The Power of Phytochemicals Combination in Cancer Chemoprevention

“…Evidence shows that lycopene reduces ovarian tumor growth [116], leads to a reduced risk in breast and prostate tumor, and can also significantly inhibit the cellular growth of colorectal [117] and lung cancer [118]. Importantly, lycopene can also alleviate radiation-induced esophagitis [119] and cisplatin-induced nephropathy [120].…”