Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet‐Induced Obese and Streptozotocin‐Induced Diabetic Mice

Abstract

Obesity is one of the major factors to increase various disorders like diabetes. The present paper emphasizes study related to the antiobesity effect of Phalaris canariensis seeds hexane extract (Al-H) in high-fat diet- (HFD-) induced obese CD1 mice and in streptozotocin-induced mild diabetic (MD) and severely diabetic (SD) mice.AL-H was orally administered to MD and SD mice at a dose of 400 mg/kg once a day for 30 days, and a set of biochemical parameters were studied: glucose, cholesterol, triglycerides, lipid peroxidation, liver and muscle glycogen, ALP, SGOT, SGPT, glucose-6-phosphatase, glucokinase, hexokinase, SOD, CAT, GSH, GPX activities, and the effect on insulin level. HS-H significantly reduced the intake of food and water and body weight loss as well as levels of blood glucose, serum cholesterol, triglyceride, lipoprotein, oxidative stress, showed a protective hepatic effect, and increased HDL-cholesterol, serum insulin in diabetic mice. The mice fed on the high-fat diet and treated with AL-H showed inhibitory activity on the lipid metabolism decreasing body weight and weight of the liver and visceral adipose tissues and cholesterol and triglycerides in the liver. We conclude that AL-H can efficiently reduce serum glucose and inhibit insulin resistance, lipid abnormalities, and oxidative stress in MD and SD mice. Our results demonstrate an antiobesity effect reducing lipid droplet accumulation in the liver, indicating that its therapeutic properties may be due to the interaction plant components soluble in the hexane extract, with any of the multiple targets involved in obesity and diabetes pathogenesis.

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

“…These results suggest that DLE may ameliorate HFD-induced hepatic steatosis through inhibition of oxidative stress. In previous studies, plant extracts have been reported to protect against obesity-induced oxidative damage in mice (41,42). Our previous study also demonstrated that DLE protects against UVB-induced oxidative damage and acetaminophen-induced oxidative liver damage in mice (38,43).…”

Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

“…The induction of obesity in animals via HFd supplementation is the most popular means of mimicking obesity in human, and a number of studies have been conducted using HFd-induced obese mouse models, in which HFd supplementation increases abdominal fat and body weights (22). Previous studies have reported crude plant extracts and natural compounds isolated from them induce weight loss and prevent diet-induced obesity (17,23).…”

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“…Protocatechuic acid (PCA) is a phenolic compound, the main metabolite of anthocyanin, which has been reported to display various pharmacological properties 7 . In the present investigation, we proposed the hypothesis that PCA exerts antiobesity, antihyperlipidemic, antidiabetic effects in the high fatty diet with a low dose of alloxan-induced in diabetic rats 8,9,10,11 .…”

“…(6) Containing lard oil (25%), fructose (40%), protein powder (45%), cholesterol (2%), vitamin and fiber contains feed. Obesity is more likely to increase the risk for hyperglycemia because of alteration in serum lipid profile like Serum Insulin level or blood glucose level 8 . Generally, a high-fat diet is one of the major factors causing obesity and that the longterm intake of high-fat diet evokes a significant increase in abdominal fat weight.…”