Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice

Eo, Hyeyoon; Lee, Heaji; Lim, Yunsook

doi:10.1016/j.bbrc.2016.07.039

Cited by 53 publications

(39 citation statements)

References 25 publications

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“…The TNF-α has been known as an inflammatory cytokine that initiates inflammation. The IL-1β is a proinflammatory cytokine that calls of neutrophils into the region of infection [11]. On the other hand, oxidative stress is known to have excessive importance in diabetes.…”

Section: Introductionmentioning

confidence: 99%

Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model

2017

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Background: Diabetes has been known as a prevalence disorder and the use of common drugs has been faced many issues with multiple limitations. This study aimed to evaluate the use of carvacrol, as a novel agent, for treatment of diabetes. Materials and Methods:A single dose of streptozotocin (55 mg/kg body weight) was used to induce the diabetes in rats. The animals were grouped into five groups including 1. Control healthy animals; 2. Diabetic controls; 3, 4 & 5. Diabetic animals given carvacrol (5, 10 and 15 mg/kg body weight/day) in neutral sterile olive oil solution oral gavage, respectively. The levels of Malondialdehyde (MDA) and catalase, Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) activities were evaluated. The levels of IL-1β, IL-6 and TNF-α expression in liver were assessed.Results: Administration of streptozotocin increased levels of MDA, IL-1β, IL-6 and TNF-α and also decreased activities of catalase, SOD and GPX (P<0.05). Oral administration of carvacrol, especially 15 mg/kg body weight/day, could decrease levels of MDA, IL-1β, IL-6 and TNF-α and also increase activities of catalase, SOD and GPX in comparison to diabetic control (P<0.05). Conclusion:Carvacrol could decrease or alleviate the negative effects of carvacrol on inflammation and antioxidant status that could be attributed to antioxidant properties. It could be recommended to apply carvacrol in commercial prescription in combination with other agents or as a single agent for treatment of diabetes.

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Section: Introductionmentioning

confidence: 99%

Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model

2017

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“…NAC was used in this study; NAC is a very important antioxidant for the immune system, mainly used as a ROS scavenger . The early stage of inflammation is a vital period during wound healing, essential for clearing the contaminating bacteria and creating an environment conducive to succeeding events involved in tissue repair and regeneration . The stage of inflammation in wounds is remarkably related to the activity of neutrophils.…”

Section: Discussionmentioning

confidence: 99%

“…41 The early stage of inflammation is a vital period during wound healing, essential for clearing the contaminating bacteria and creating an environment conducive to succeeding events involved in tissue repair and regeneration. 42 The stage of inflammation in wounds is remarkably related to the activity of neutrophils. During this period, the recruitment and function of neutrophils have been shown to be regulated by several cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-a (TNF-a) whose expressions were regulated by nuclear factor kappa B (NFκB).…”

Section: Discussionmentioning

confidence: 99%

Sustained release of N‐acetylcysteine by sandwich structured polycaprolactone/collagen scaffolds for wound healing

Hou

Chen

Liu

et al. 2019

J Biomedical Materials Res

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PCL (poly‐caprolactone) nanofibers have good biocompatibility and high porosity, which are usually utilized for application in wound dressings. However, wound healing could be hindered by the overproduction of reactive oxygen species (ROS) and different factors. Pure nanofibers cannot satisfy these requirements of wound healing. N‐acetylcysteine (NAC), as an antioxidant, meets the requirements for wound healing by resisting the overproduction of ROS and by promoting angiogenesis and maturation of the epidermis. In this study, we prepared a sandwich structured PCL‐Col/NAC scaffold using the molding method, which consisted of PCL nanofibers at the core and NAC‐loaded collagen on both sides. The hydroscopicity and tensile modulus of PCL‐Col/NAC scaffolds showed best performance of these properties among groups. Meanwhile, the drug release profiles of PCL‐Col/NAC scaffolds were investigated using the HPLC method and the results suggested a sustained drug release of NAC for PCL‐Col/NAC scaffolds. In addition, PCL‐Col/NAC scaffolds presented better properties than the control groups in cell migration and proliferation. The in vivo wound healing therapy effect was studied using an oval (2 × 1 cm) full‐thickness skin defect wound model for SD rats. After 21 days, gross view and histological analysis showed a favorable beneficial therapeutic effect as well as better epidermal maturation compared with the control groups. CD31 immunohistology results revealed relatively more new vessels in the PCL‐Col/NAC group than the control groups. This study developed novel PCL‐Col/NAC scaffolds with an excellent hydroscopicity, tensile modulus and the ability to promote epidermal maturation and angiogenesis, demonstrating its promising potential in wound healing treatment. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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“…Tumor Necrosis Factor-α (TNF-α) is one pro-inflammatory cytokine in border line of inflammation process. Interleukin-1β (IL-1β) as other pro-inflammatory cytokine stimulates neutrophils into region of infection [14].…”

mentioning

confidence: 99%

“…Nuclear Factor-kappa B (NF-κB) increases production of TNF-α and IL-1β [14]. C-Reactive Protein (CRP) is one inflammatory marker that is associated with increased systemic inflammatory response syndrome [15].…”

mentioning

confidence: 99%

Relation Between Novel Markers with Sperm Quality in Obese Rats

2018

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Background: Obesity and inflammation stemmed from obesity basically affects fertility and male reproductive system by its negative effect on erectile dysfunction and semen variables. Novel factors could be used to determine the fertility and infertility. This study was conducted to evaluate the relation between novel markers with sperm quality in obese rats. Materials and Methods: Animals were grouped into 2 groups including normal group received normal rat pellet diet for 12 weeks of intervention, while other group received a high fat diet. The serum concentrations of IL-1β, IL-6, IL-3, TNF-α, sialic acid, CRP, haptoglobin and fibrinogen were measured. Sperm motility was assessed. Results: Results showed that progressive motility and non-progressive motility and immotile were respectively lower and higher in obese rats in comparison to control groups (P<0.05). It was observed positive correlation between inflammatory factors and immobility and negative correlation between progressive motility with inflammation (P<0.05). Conclusion: Pro-inflammatory factors had significant correlation with sperm quality and could be used as markers for infertility.

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Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice

Cited by 53 publications

References 25 publications

Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model

Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model

Sustained release of N‐acetylcysteine by sandwich structured polycaprolactone/collagen scaffolds for wound healing

Relation Between Novel Markers with Sperm Quality in Obese Rats

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