Background: Diabetes has been known as a prevalence disorder and the use of common drugs has been faced many issues with multiple limitations. This study aimed to evaluate the use of carvacrol, as a novel agent, for treatment of diabetes. Materials and Methods:A single dose of streptozotocin (55 mg/kg body weight) was used to induce the diabetes in rats. The animals were grouped into five groups including 1. Control healthy animals; 2. Diabetic controls; 3, 4 & 5. Diabetic animals given carvacrol (5, 10 and 15 mg/kg body weight/day) in neutral sterile olive oil solution oral gavage, respectively. The levels of Malondialdehyde (MDA) and catalase, Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) activities were evaluated. The levels of IL-1β, IL-6 and TNF-α expression in liver were assessed.Results: Administration of streptozotocin increased levels of MDA, IL-1β, IL-6 and TNF-α and also decreased activities of catalase, SOD and GPX (P<0.05). Oral administration of carvacrol, especially 15 mg/kg body weight/day, could decrease levels of MDA, IL-1β, IL-6 and TNF-α and also increase activities of catalase, SOD and GPX in comparison to diabetic control (P<0.05). Conclusion:Carvacrol could decrease or alleviate the negative effects of carvacrol on inflammation and antioxidant status that could be attributed to antioxidant properties. It could be recommended to apply carvacrol in commercial prescription in combination with other agents or as a single agent for treatment of diabetes.
Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding CASRP΄s archiving and manuscript policies encouraged to visit: http://www.casrp.co.uk/journals AbstractHuman T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycobacterium tuberculosis,HTLV and were collected from Imam Khomeini hospital in Tehran, Iran. 100 cases were investigated (58% males, 42% females), the age of these samples were within 5 to 89 years old.In 65.7 percent of the leukemia rate HTLV-1 has been positive. Five cases (54%) were myeloid leukemia, 36.4% cases were not myeloid leukemia and 3 out of 8 cases (27.9%) unclassified lymphomas, were positive respectively. All 6 cases (100%) were adults with acute T-cell leukemia/lymphoma (ATLL) and Mycobacterium tuberculosis were positive. Among all cases, just one case has been positive for chronic myeloid leukemia and myeloproliferative disruption. Positive HTLV-1-show more in older ages than younger one. At younger ages offers less than negative items. According to our results, in Iran HTLV-1, 2 153 is dramatically related to myeloid leukemia, and more studies are required for accurate connection with myeloma diseases and this area.
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