Amelioration of renal and hepatic function, oxidative stress, inflammation and histopathologic damages by Malva sylvestris extract in gentamicin induced renal toxicity

Yarijani, Zeynab Mohamadi; Najafi, Hossein; Shackebaei, Dareuosh; Madani, Seyed Hamid; Modarresi, Masoud; Jassemi, Seyed Vahid

doi:10.1016/j.biopha.2019.108635

Cited by 45 publications

(15 citation statements)

References 52 publications

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“…Positive findings have also been reported by another study [100]. It showed that the administration of Malva sylvestris L. extract (200 or 400 mg/kg) rich in anthocyanins reduced the renal toxicity induced by gentamicin and thus led to (i) an improvement in kidney function, (ii) a decrease in the expression levels of pro-inflammatory markers (TNF-α), (iii) a reduction in oxidative stress (levels of malondialdehyde and total antioxidant capacity), and (iv) a decrease in tissue injuries.…”

Section: Nephroprotective Effectssupporting

confidence: 84%

Anthocyanins: From the Field to the Antioxidants in the Body

et al. 2020

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Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as natural food colorants to be used in yogurts, juices, marmalades, and bakery products. Numerous studies have also indicated the beneficial health effects of anthocyanins and their metabolites on human or animal organisms, including free-radical scavenging and antioxidant activity. Thus, our aim was to review the current knowledge about anthocyanin occurrence in plants, their stability during processing, and also the bioavailability and protective effects related to the antioxidant activity of anthocyanins in human and animal brains, hearts, livers, and kidneys.

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Section: Nephroprotective Effectssupporting

confidence: 84%

Anthocyanins: From the Field to the Antioxidants in the Body

et al. 2020

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“…Forward and reverse primer sequences for beta-actin were 5′-TGCTATGTTGCCCTAGACTTC-3′ and 5′-GTTGGCATAGAGGTCTTTACGG-3′, respectively. 28 …”

Section: Methodsmentioning

confidence: 99%

Protective effect of piperine in ischemia-reperfusion induced acute kidney injury through inhibition of inflammation and oxidative stress

Mohammadi

Najafi

Yarijani

et al. 2020

Journal of Traditional and Complementary Medicine

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Background and aim Renal ischemia-reperfusion is associated with inflammation and oxidative stress. As a major compound in black pepper, piperine has anti-inflammatory and anti-oxidative properties. In present study, the protective effects of oral administration of piperine in renal ischemia-reperfusion (IR) induced acute kidney injuries (AKI) were investigated. Experimental procedure Male Wistar rats received piperine (10 or 20 mg/kg.bw) or vehicle for 10 days. The artery and vein of both kidneys were then clamped for 30 min, followed by a 24-h reperfusion period. Concentrations of creatinine and urea-nitrogen in descending aorta blood were measured, and malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) levels were measured in kidney tissue to evaluate the oxidative stress. Inflammation was evaluated by measuring the TNF-α and ICAM-1 mRNA expression levels in renal cortical tissue using Real Time PCR method and counting leukocytes infiltration to interstitium. Further measured were tissue damages in H & E stained sections. Results Renal IR reduced FRAP, while increasing the plasma concentrations of creatinine and urea-nitrogen, tissue MDA level, TNF-α and ICAM-1 mRNA expressions, leukocyte infiltration and histopathologic injuries. Piperine administration significantly reduced the plasma concentrations of creatinine and urea-nitrogen, expression of pro-inflammatory factors, oxidative stress and renal histopathologic injuries. It is to be noted that 20 mg/kg dose was more effective. Conclusion Our results suggest piperine protects the kidney against ischemia-reperfusion induced acute kidney injuries by its anti-inflammatory and anti-oxidative properties.

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“…Kidneys were resected and fixed in a 10% formaldehyde solution, embedded in paraffin, and cut into 5-μm sections, which were deparaffinized, hydrated, and stained with hematoxylin and eosin. The sections were then evaluated for indicators of cell damage as previously described with some modifications [28–30]. The histopathological changes analyzed were tubular necrosis, proteinaceous casts, exfoliated cells in the lumen, Bowman’s space enlargement, lymphocytes in peritubular capillaries, medullary congestion, and intracellular vacuolization.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia–reperfusion damage in a Wistar rat model

Pérez-Meseguer

Torres-González

Gutiérrez-González

et al. 2019

BMC Complement Altern Med

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Background Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We evaluated whether a methanolic extract of Juglans mollis (JM) exhibits nephroprotective activity in a Wistar rat model of I/R injury. Methods Four groups of six rats were used: Sham, I/R, JM, and JM + I/R. Two groups were dosed with JM (300 mg/kg) for 7 days before I/R. I/R injury was induced by clamping the renal hilums for 45 min and then reperfusing the kidneys for 15 h. Blood samples were taken to evaluate the levels of alanine aminotransferase (ALT), blood urea nitrogen, creatinine, superoxide dismutase (SOD), malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α). Results The levels of creatinine, ALT, MDA, IL-1β, IL-6, and TNF-α were lower in JM + I/R than in I/R rats, whereas SOD level only was higher in JM + I/R than in Sham rats. No biochemical or histological damage was observed in JM rats compared with Sham rats; however, less histological damage was observed in JM + I/R rats compared with I/R rats. Conclusions To our knowledge, this is the first report of nephroprotective activity of J. mollis against damage induced by I/R. This activity may be related to decreased levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and modulation of oxidative stress markers (SOD and MDA) observed in the present study.

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Amelioration of renal and hepatic function, oxidative stress, inflammation and histopathologic damages by Malva sylvestris extract in gentamicin induced renal toxicity

Cited by 45 publications

References 52 publications

Anthocyanins: From the Field to the Antioxidants in the Body

Anthocyanins: From the Field to the Antioxidants in the Body

Protective effect of piperine in ischemia-reperfusion induced acute kidney injury through inhibition of inflammation and oxidative stress

Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia–reperfusion damage in a Wistar rat model

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