Amelioration of obesity in high-fat diet-fed mice by chestnut starch modified by amylosucrase from Deinococcus geothermalis

Lee, Eun-Sook; Yoo, Sang‐Ho; Shin, Dong Uk; Lim, Miyoung; Chung, Won‐Hyong; Park, Cheon-Seok; Baik, Moo-Yeol; Nam, Young-Do; Seo, Dong-Ho

doi:10.1016/j.foodhyd.2017.09.019

Cited by 20 publications

(9 citation statements)

References 53 publications

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“…In this experiment, the concentrations of GLU, TG and TC were notably increased in high-fat diet-induced obese rats, and studies have demonstrated that the accumulation of serum lipids is considered to be the major factor in the risk of cardiovascular disease accompanied by an increase in GLU, TG, TC, and LDL-C levels and a decrease in HDL-C levels ( Dyrbus et al, 2018 ). BRS significantly reduced GLU, TC, TG, and LDL-C levels in serum compared to the MC group during 6 weeks of BRS supplementation, which is consistent with previous literature ( Lee et al, 2018 ), suggesting that BRS may play an effective role in ameliorating abnormal blood glucose and lipid metabolism induced by obesity.…”

Section: Discussionsupporting

confidence: 91%

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

Wang

Tan

et al. 2021

Front. Bioeng. Biotechnol.

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The effects of banana resistant starch (BRS) on obesity-related metabolic and intestinal flora were investigated in a high-fat diet-induced obesity model. After 6 weeks of intervention, the glucolipid metabolism index [blood glucose (GLU), total cholesterol (TC), triacylglycerol (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C)], hormone index [leptin (LEP), insulin (INS), ghrelin, adiponectin (ADP), and thyroxine (T4)], and 16S rRNA sequencing analyses were performed for each group to explore the regulating effect of intestinal flora and the mechanism of weight loss in obese rats. The results showed that (1) BRS intervention significantly reduced the levels of GLU, TG, TC, LDL-C, LEP, and INS (p < 0.01) and increased the contents of ghrelin (p < 0.05) and ADP (p < 0.01). (2) BRS could improve the diversity of intestinal flora and regulate the overall structure of intestinal microorganisms, mainly by upregulating the Bacteroides/Firmicutes ratio and the relative abundance of Cyanobacteria and downregulating the relative abundances of Deferribacteres and Tenericutes (at the phylum level). BRS could inhibit the proliferation of Turicibacter, Romboutsia, and Oligella and increase the abundances of Bacteroides, Ruminococcaceae, and Lachnospiraceae (at the genus level). (3) Some significant correlations were observed between the gut microbiota and biomarkers. Turicibacter, Romboutsia, and Oligella were positively correlated with GLU, TG, TC, LEP, and INS and negatively correlated with ghrelin and ADP. Bacteroides, Parabacteroides, and Akkermansia were negatively correlated with GLU, TG, and TC. Conclusion: BRS had promising effects on weight loss, which could be associated with the improvement in host metabolism by regulating intestinal flora.

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Section: Discussionsupporting

confidence: 91%

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

Wang

Tan

et al. 2021

Front. Bioeng. Biotechnol.

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“…Activation of GPR43 receptor could increase Ca 2+ in intestinal L cells, further promoting the secretion of GLP-1 and PYY so as to lower the level of FBG. It has been demonstrated that mice with GPR43 gene knockout presented an obese phenotype, excessive accumulation of fat, and predisposition to obstacles of insulin signal transmission, thus inducing insulin resistance [ 28 ]. According to an animal experiment, supplementation with probiotic bacteria upregulated the expression of GPR43 receptor, repaired glucose intolerance, and reduced the level of blood glucose in T2DM rats [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of yam gruel on lowering fasted blood glucose in T2DM rats

Luo

Pang

et al. 2020

Open Life Sciences

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There is increasing evidence of the linkage between type 2 diabetes mellitus (T2DM) and gut microbiota. Based on our previous studies, we investigated the hypoglycemic mechanisms of yam gruel to provide a scientific basis for its popularization and application. Wistar rats were randomly divided into control and T2DM model groups. Rats in the model group were stimulated by a high-sugar/high-fat diet combined with an intraperitoneal injection of streptozotocin to induce T2DM. The T2DM rats were further subdivided randomly into three groups: (1) DM, (2) DM + yam gruel, and (3) DM + metformin. After 4 weeks of intervention, the changes in gut microbiota, short-chain fatty acids (SCFAs) (acetic acid, propionic acid, and butyric acid), the expression of G protein-coupled receptor 43 (GPR43), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and fasted blood glucose (FBG) levels were observed. Yam gruel intervention elevated the abundance of probiotic bacteria and increased the expression of SCFAs, GPR43 receptor, GLP-1, and PYY. It also reduced FBG levels. We conclude that yam gruel can lower FBG by promoting the growth of probiotic bacteria, increasing the content of SCFAs, and enhancing the expression of GPR43 receptor to increase the content of GLP-1 and PYY in serum.

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“…In this experiment, the concentrations of GLU, TG and TC were notably increased in high-fat diet-induced obese rats, and studies have demonstrated that the accumulation of serum lipids is considered to be the major factor in the risk of cardiovascular disease accompanied by an increase in GLU, TG, TC, and LDL-C levels and a decrease in HDL-C levels (Dyrbus et al, 2018). BRS significantly reduced GLU, TC, TG, and LDL-C levels in serum compared to the MC group during 6 weeks of BRS supplementation, which is consistent with previous literature (Lee et al, 2018), suggesting that BRS may play an effective role in ameliorating abnormal blood glucose and lipid metabolism induced by obesity.…”

Section: Discussionsupporting

confidence: 90%

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Amelioration of obesity in high-fat diet-fed mice by chestnut starch modified by amylosucrase from Deinococcus geothermalis

Cited by 20 publications

References 53 publications

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

The effects of yam gruel on lowering fasted blood glucose in T2DM rats

Data_Sheet_1.docx

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