Amelioration of metabolic disturbances and adipokine dysregulation by mugwort (<i>Artemisia princeps P.</i>) extract in high-fat diet-induced obese rats

Kim, Yun-Hye; Park, Chung-Mu; Yoon, Gun-Ae

doi:10.4163/jnh.2016.49.6.411

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…However, only HWEs had an effect similar to MTF, while the efficacy of CWEs and ALEs was lower compared to MTF. These findings are consistent with those of another study, which confirmed that mice with HFD-induced obesity that were treated with mugwort extract of A. princeps Pampanini for 6 weeks showed enhanced serum adiponectin and decreased serum leptin levels [ 31 ]. Leptin is an insulin sensitizer secreted from adipose tissues that improves insulin sensitivity by direct action on peripheral tissues [ 30 ].…”

Section: Discussionsupporting

confidence: 92%

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

et al. 2022

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Objectives: Insulin resistance (IR) is major cause of type 2 diabetes (T2D), and adipokines (e.g., adiponectin, leptin, and resistin) play an important role in insulin sensitivity. Medicinal plants are frequently used for T2D treatment. This study investigates the effect of Artemisia annua L. (AA) extracts on adipokines in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced T2D. Methods: We divided 60 mice into 12 groups (n = 5 per group): control, untreated T2D, treated T2D, and 9 other groups. T2D was induced in all groups, except controls, by 8 weeks of HFD and STZ injection. The treated T2D group was administered 250 mg/kg of metformin (MTF), while the nine other groups were treated with 100, 200, and 400 mg/kg of hot-water extract (HWE), cold-water extract (CWE), and alcoholic extract (ALE) of AA (daily oral gavage) along with 250 mg/kg of MTF for 4 weeks. The intraperitoneal glucose tolerance test (IPGTT) was performed, and the homeostasis model assessment of adiponectin (HOMA-AD) index and blood glucose and serum insulin, leptin, adiponectin, and resistin levels were measured. Results: Similar to MTF, all three types of AA extracts (HWEs, CWEs, and ALEs) significantly (p < 0.0001) decreased the area under the curve (AUC) of glucose during the IPGTT, the HOMA-AD index, blood glucose levels, and serum insulin, leptin, and resistin levels and increased serum adiponectin levels in the MTF group compared to the T2D group (p < 0.0001). The HWEs affected adipokine release, while the CWEs and ALEs decreased leptin and resistin production. Conclusion: Water and alcoholic AA extracts have an antihyperglycemic and antihyperinsulinemic effect on HFD/STZ diabetic mice. In addition, they decrease IR by reducing leptin and resistin production and increasing adiponectin secretion from adipocytes.

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Section: Discussionsupporting

confidence: 92%

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

et al. 2022

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“…인진쑥은 황달, 간염, 간경화 등의 치료에, 사자발쑥은 당뇨, 동맥 경화, 염증 등의 치료에, 개똥쑥은 해열, 이담, 악창 등의 질병 치료를 위해 이용되어 왔다 29,30) . 특히 고지방식이 유 도 비만 동물모델에서 쑥 추출물 투여 시 지질대사, 인슐 린 저항성, 아디포카인 분비 조절 등을 통해 항비만 효능 이 보고됨에 따라 비만 개선용 소재로서 연구가 활발히 이루어지고 있다 31,32) .…”

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Antioxidant Activity Study of Artemisia argyi H. Extract Fermented with Lactic Acid Bacteria

Kim

Lee

et al. 2022

JKOMOR

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Inhibitory Effects of Brassica rapa L. and Raphanus sativus L. on Adipogenesis and Lipogenesis through PI3K/AKT Pathway Regulation in C3H10T1/2 Cells

Hwang

Park

Hwang

et al. 2022

JKFN

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Radish (Raphanus sativus L.) is a representative root vegetable widely cultivated in Asia and known to have various physiological effects, such as gastric protective, anti-inflammatory, antioxidant, and hemostasis improving effects, and to ameliorate digestive disorders. However, studies on the antiobesity effects of white and red radish are inadequate. Therefore, in this study, the anti-adipogenic and anti-lipogenic effects of Ganghwa (RG) and Jeju (RJ) radishes were investigated in C3H10T1/2 cells. Lipid accumulation inhibition by Oil Red O staining and TG contents confirmed that at 1,000 μg/mL RG and RJ significantly inhibited lipid accumulation and dose-dependently reduced the mRNA and protein levels of major adipogenesis and lipogenesis-related factors. In addition, inhibition of the expression of genes in the PI3K/Akt pathway by RG or RJ markedly increased leptin and adiponectin levels. These results indicate radishes are potential functional materials that inhibit adipocyte differentiation and lipid accumulation.

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Amelioration of metabolic disturbances and adipokine dysregulation by mugwort (Artemisia princeps P.) extract in high-fat diet-induced obese rats

Cited by 3 publications

References 40 publications

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

Antioxidant Activity Study of Artemisia argyi H. Extract Fermented with Lactic Acid Bacteria

Inhibitory Effects of Brassica rapa L. and Raphanus sativus L. on Adipogenesis and Lipogenesis through PI3K/AKT Pathway Regulation in C3H10T1/2 Cells

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