Amelioration of Liver Damage Induced by Ischemia and Reperfusion with FR167653; A Newly Synthesized Cytokine Suppressive Antiinflammatory Drug

FR167653, a potent suppressant of interleukin‐1 and tumor necrosis factor‐α production, ameliorates colonic lesions in experimentally induced acute colitis1

“…These novel strategies have brought different interesting results together with enthusiasm because of their innovative approach. Recently, FR167653, which is a potent inhibitor of IL‐1 and TNF‐α, has been evaluated for several experimentally induced inflammatory conditions with encouraging results with respect to anticytokine therapy 8–11 . Nevertheless, the effect of FR167653 on preventing experimentally induced colitis has not been investigated.…”

“…In the present study, we investigated the possible therapeutic effect of various doses of FR167653 on the acetic acid‐induced colitis model in rats. Previous studies have tested several doses and routes of administration of FR167653 8,9 . A beneficial and dose‐dependent effect of FR167653 (0.10–0.32 mg/kg per h, i.v.…”

“…FR167653 is a newly synthesized organic compound that has been identified as a potent suppressant of IL‐1β and TNF‐α production. This compound had beneficial effects when administered on experimental ischemia‐reperfusion injury of the small intestine, 8 liver injury induced by warm ischemia‐reperfusion in dogs, 9 indomethacin‐induced small intestinal lesion in rats, 10 and experimental pancreatitis in rats 11 . We hypothesized that the suppression of TNF‐α and IL‐1 induced by FR167653 could effectively attenuate the colonic damage induced by acetic acid instillation.…”