Amelioration of hyperglycemia, hyperlipidemia, oxidative stress and inflammation in steptozotocin-induced diabetic rats fed a high fat diet by riceberry supplement

Prangthip, Pattaneeya; Surasiang, R.; Charoensiri, Rin; Leardkamolkarn, Vijittra; Komindr, Surat; Yamborisut, Uruwan; Vanavichit, Apichart; Kongkachuichai, Ratchanee

doi:10.1016/j.jff.2012.10.005

Cited by 53 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding was found in agreement with the results of Prangthip et al [64]. Taurine administration prevented the occurrence and development of diabetic nephropathy by decreasing blood glucose, improving lipid metabolism and glomerular basement membrane metabolism [65].…”

Section: Discussionsupporting

confidence: 92%

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

2016

IJSR

View full text Add to dashboard Cite

The present study was conducted to investigate the beneficial effects of taurine (TAU) on glucose and lipid metabolism and its positive roles in the correction of oxidative stress diabetes-related complications in STZ diabetic rats. Diabetic rats showed significant (P<0.05) increase in the levels of glucose, HbA1c, AST, ALT, LDH, liver and kidney weights, urea, uric acid, creatinine and significant decrease in the levels of body and pancreas weights, insulin, pancreatic amylase, hexokinase, liver and muscle glycogen, total protein, albumin, antioxidant enzymes and HDL-C. Also, higher levels of cholesterol, TG, total lipids, LDL-C and MDA were noticed in diabetic rats. The taurine administration (50 mg/kg) showed antihyperglycemic effect as indicated by reduced glucose levels, HbA1c and improved insulin level and carbohydrate hydrolyzing enzymes. In addition, taurine supplementation normalized liver function and inhibited lipid prfile alterations while, kidney weight, urea, creatinine, uric acid, total protein and albumin levels were partially improved. The obtained results revealed that taurine exhibited an inhibitory effect on oxidative stress indices (MDA) and partially improved antioxidantlevels. Taurine could have potential as a pharmaceutical drug for diabetes mellitus (DM). Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

2016

IJSR

View full text Add to dashboard Cite

show abstract

“…Currently, many researchers have reported that animals fed with HFD promote insulin resistance (Farrokhfall, Khoshbaten, Zahediasl, Mehrani, & Karbalaei, 2014;Prangthip et al, 2013;Tahara, Matsuyama-Yokono, & Shibasaki, 2011). In order to develop insulin resistance, rats were fed with HFD for 6 weeks that increased the body weight (obesity) and mild hyperglycemia, a condition resembling prediabetic state in humans.…”

Section: Discussionmentioning

confidence: 99%

Flavanone naringenin: An effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats

Priscilla

Jayakumar

Thirumurugan

2015

Journal of Functional Foods

View full text Add to dashboard Cite

“…The extract of Riceberry bran has recently been reported by our group to have potential chemopreventive activity against human cancer cell lines, Caco-2, MCF-7, and HL-60 [ 10 ]. This extract also has hypoglycemic, hypolipidemic, antioxidant, and anti-inflammation properties [ 11 ]. Riceberry bran oil supplement is also noted to be beneficial to oxidative stress and organ histology in streptozotocin-induced diabetic rats fed with a high fat diet [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Structures of Phytosterols and Triterpenoids with Potential Anti-Cancer Activity in Bran of Black Non-Glutinous Rice

et al. 2015

Self Cite

View full text Add to dashboard Cite

Structures of some bioactive phytochemicals in bran extract of the black rice cv. Riceberry that had demonstrated anti-cancer activity in leukemic cell line were investigated. After saponification with potassium hydroxide, separation of the unsaponified fraction by reversed-phase high performance liquid chromatography (HPLC) resulted in four sub-fractions that had a certain degree of anti-proliferation against a mouse leukemic cell line (WEHI-3 cell), this being IC50 at 24 h ranging between 2.80–467.11 μg/mL. Further purification of the bioactive substances contained in these four sub-fractions was performed by normal-phase HPLC. Structural characterization by gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (NMR) resulted in, overall, the structures of seven phytosterols and four triterpenoids. Four phytosterols, 24-methylene-ergosta-5-en-3β-ol, 24-methylene-ergosta-7-en-3β-ol, fucosterol, and gramisterol, along with three triterpenoids, cycloeucalenol, lupenone, and lupeol, were found in the two sub-fractions that showed strong anti-leukemic cell proliferation (IC50 = 2.80 and 32.89 μg/mL). The other sterols and triterpenoids were campesterol, stigmasterol, β-sitosterol and 24-methylenecycloartanol. Together with the data from in vitro biological analysis, we suggest that gramisterol is a significant anti-cancer lead compound in Riceberry bran extract.

show abstract

Amelioration of hyperglycemia, hyperlipidemia, oxidative stress and inflammation in steptozotocin-induced diabetic rats fed a high fat diet by riceberry supplement

Cited by 53 publications

References 26 publications

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

Flavanone naringenin: An effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats

Structures of Phytosterols and Triterpenoids with Potential Anti-Cancer Activity in Bran of Black Non-Glutinous Rice

Contact Info

Product

Resources

About