Amelioration of Diabetes-Induced Nephropathy by Loranthus regularis: Implication of Oxidative Stress, Inflammation and Hyperlipidaemia

Alanazi, Ahmed Z.; Mohany, Mohamed; Alasmari, Fawaz; Mothana, Ramzi A.; Alshehri, Abdulaziz O; Alhazzani, Khalid; Ahmed, Mohammed M.; Al‐Rejaie, Salim S.

doi:10.3390/app11104548

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Previous studies reported that the active components of L. regularis served as antioxidant, antimicrobial, and anti-inflammatory factors [27,28]. More recently, our research team has investigated the potential beneficial effects of L. regularis against inflammation and oxidative stress in diabetes-induced hepatocellular damage and nephropathy [29,30]. L. regularis and its constituents, being bioactive with a potentially beneficial role in combating diabetes and its complications, here we used oral treatments of this plant extract to protect neurodegenerative factors in the retina of STZ-induced rats.…”

Section: Introductionmentioning

confidence: 98%

Loranthus regularis Ameliorates Neurodegenerative Factors in the Diabetic Rat Retina

et al. 2022

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Diabetic retinopathy remains a primary source of blindness with the growing pandemic of diabetes. Numerous studies have shown that early neurodegeneration caused by elevated oxidative stress may initiate microvascular damage in the diabetic retina during the last few decades. A variety of preventive and treatment strategies using phytochemicals that possess high antioxidants have shown great promise in reducing diabetes-induced neurodegeneration retinal damage. In this investigation, we employed an extract of Loranthus regularis, a traditional medicinal herb which is found to improve diabetes and associated complications in experimental studies. We orally treated STZ-induced diabetic rats with L. regularis and analyzed the neurodegenerative factors in the retina. After treatments, we used Western blotting techniques to analyze the protein content of neurotrophic factors (NGF, BDNF, TrkB), apoptotic factors (cytochrome c, Bcl-2, Bax), and phosphorylation of AKT in the diabetic retina. Additionally, we used ELISA methods to measure the contents of BDNF and the activity of Caspase-3 and biochemical procedures to determine the levels of glutathione and lipid peroxidation (TBARS). Our findings show that L. regularis treatments resulted in a considerable increase in neurotrophic factors and a decrease in apoptotic factors in the diabetic retina. Furthermore, in diabetic retina treated with L. regularis, the level of Bcl-2 protein increased, while the phosphor-AKT signaling improved. As a result, L. regularis may protect against diabetic-induced retinal neuronal damage by increasing neurotrophic support and reducing oxidative stress and apoptosis. Therefore, this study suggests that in diabetic retinopathy, L. regularis could be a potential therapy option for preventing neuronal cell death.

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Section: Introductionmentioning

confidence: 98%

Loranthus regularis Ameliorates Neurodegenerative Factors in the Diabetic Rat Retina

et al. 2022

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“…Serum creatinine and urine albumin were reduced after the treatment. The result was supported by histological report of the kidney for DN, and it indicated that combination therapy for 16 weeks indicated a reduction in levels of lipid profiles and an increase in the high density lipoprotein cholesterol of diabetes treated rats [ 20 , 93 ].…”

Section: Medicinal Plants and Diabetic Nephropathymentioning

confidence: 75%

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Sultana

Farooq

et al. 2022

CIMB

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Diabetic nephropathy (DN) is a serious kidney illness characterized by proteinuria, glomerular enlargement, reduced glomerular filtration, and renal fibrosis. DN is the most common cause of end-stage kidney disease, accounting for nearly one-third of all cases of diabetes worldwide. Hyperglycemia is a major factor in the onset and progression of diabetic nephropathy. Many contemporary medicines are derived from plants since they have therapeutic properties and are relatively free of adverse effects. Glycosides, alkaloids, terpenoids, and flavonoids are among the few chemical compounds found in plants that are utilized to treat diabetic nephropathy. The purpose of this review was to consolidate information on the clinical and pharmacological evidence supporting the use of a variety of medicinal plants to treat diabetic nephropathy.

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“…Even though many plants are currently employed in food consumption and medication manufacturing, herbal medicines seem to be an underused weapon for preventing many diseases [ 29 – 31 ]. These data make studying novel natural effects derived from plants an immediate concern.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of flaxseed lignan-enriched extract targeting autophagy, apoptosis, and hedgehog pathways against experimentally induced obesity

Khater,

Shalabi,

Alammash

et al. 2023

J Adv Vet Anim Res

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Objective: This research investigated secoisolariciresinol diglucoside (SDG) flax extract effects on apoptosis, hedgehog (Hh), autophagy, and the anti-oxidation process in experimentally induced obesity. Materials and Methods: Forty rats were separated into two sets regarding either receiving a nor¬mal balanced diet or a high-fat diet (HFD) and then distributed into four groups: GI: The control group had a regular diet for 12 weeks. GII: animals received a high-fat meal and saline by gastric gavage. GIII: HFD obese rats treated with SDG extract orally (10 mg/kg/b.w.) and 1.18 mg SDG/kg in the diet for 4 weeks GIV: Normal balanced diet rats received SDG extract orally (10 mg/kg/b.w.) and 1.18 mg SDG/kg of chow for 12 weeks in addition to their regular balanced diet. Results: The administration of SDG extract exhibited a significant drop in body weight, glucose, lipid profile, and leptin compared to the obese group. It also improved the antioxidant levels (lowering the levels of malondialdehyde while increasing the total antioxidant capacity) and anti-inflammatory status (decreasing interleukin-6 and tumor necrosis factor-alpha). SDG extract downregulates the expression of HH genes (protein patched homolog 1, Hh-interacting protein, glioma-associated oncogene homolog 1, and smoothened receptor) in conjunction with the mod¬ulation of autophagy genes and apoptotic proteins. Conclusion: SDG extract showed improved anti-inflammatory and antioxidant status and down¬regulated the expression of HH genes while modulating autophagy genes and apoptotic proteins among obese rats, suggesting that it may be used to avert and manage obesity and its correlated complications by modulating oxidation, inflammation, autophagy, and apoptosis. Advanced future research on the SDG autophagy pathway to address obesity and its complications is mandatory.

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Amelioration of Diabetes-Induced Nephropathy by Loranthus regularis: Implication of Oxidative Stress, Inflammation and Hyperlipidaemia

Cited by 5 publications

References 42 publications

Loranthus regularis Ameliorates Neurodegenerative Factors in the Diabetic Rat Retina

Loranthus regularis Ameliorates Neurodegenerative Factors in the Diabetic Rat Retina

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Evaluation of flaxseed lignan-enriched extract targeting autophagy, apoptosis, and hedgehog pathways against experimentally induced obesity

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