Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress

Sharma, Shikha; Sahu, D. R.; Das, Hasi R.; Sharma, Deepak

doi:10.1016/j.fct.2011.08.013

Cited by 61 publications

(45 citation statements)

References 45 publications

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“…Further, endogenous lipid peroxides and toxic electrophiles are taken care by GST [39]. The current study demonstrated a significant increase in the activity of SOD, CAT and GST in the liver of arthritic rats as reported by previous studies [40]. In contrast, all the three enzymes were found decreased in the spleen as observed by Olszewski [41].…”

Section: Discussionsupporting

confidence: 86%

Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status

et al. 2012

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Purpose The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. Methods Arthritis was induced using Freund's complete adjuvant to hind paw of experimental rats. The physical and biochemical alterations and its recovery by sesamol were assessed by measuring enzymatic and non-enzymatic mediators. Arthritis-induced inflammation, oxidative stress and their protective by sesamol were measured by determining the levels of pro-inflammatory cytokines and oxidative stress markers. Results In the present study, sesamol was demonstrated to alleviate arthritis-induced cartilage degeneration by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases (MMP-13, MMP-3 and MMP-9). It also protected bone resorption by reducing the elevated levels of bone joint exoglycosidases, cathepsin D and tartarate-resistant acid phosphatases. Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL1b, IL-6, COX-2, PGE 2 , ROS, and H 2 O 2 ,) effectively. In addition, sesamol neutralizes arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase. Conclusion Taken together, the study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Thus, sesamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes.

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Section: Discussionsupporting

confidence: 86%

Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status

et al. 2012

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“…The present study shows that lower level of MDA of HSBE extract (250 mg/kg & 500 mg/kg) can suppress the ROS, that were more elevated in case of disease control group. Catalase is another antioxidant enzyme which protects cells from superoxide radicals by interacting endogenous H 2 O 2 and liberating water and oxygen 48 . Earlier studies have shown that catalase levels decreased in chronic inflammatory states 49 .…”

Section: Discussionmentioning

confidence: 99%

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2016

IJPSR

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“…Despite being more potent than ASA, on a molar basis, the salicin amount in WBE is much less than the salicylate content of ASA, suggesting that active principles other than salicin might play a role in the antiinflammatory and antioxidative action of WBE, the polyphenols being among the candidates, at least regarding the protection against free radicals [68]. The ability to mitigate pro-inflammatory cytokines and oxidative stress was corroborated by still another study on the collagen induced arthritis animal model [69].…”

Section: Salix Spp Fam Salicaceaementioning

confidence: 55%

Phytomedicine in Joint Disorders

Dragoș

Gîlcă

Găman

et al. 2017

Preprint

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Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from painkillers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and an efficiency frequently comparable with that of conventional drugs. Nevertheless, their mechanism of action is in many cases elusive and/or uncertain. Even many of them have been proved effective in studies done in vitro or on animal models, there is a scarcity of human clinical evidence. The purpose of this review is to summarise the available scientific information on these joint-friendly medicinal plants, which have been already tested in human studies: Arnica montana, Boswellia spp., Curcuma spp., Equisetum arvense, Harpagophytum procumbens, Salix spp., Sesamum indicum, Symphytum officinalis, Zingiber officinalis, Panax notoginseng, Whitania somnifera.

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Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress

Cited by 61 publications

References 45 publications

Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status

Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status

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Phytomedicine in Joint Disorders

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