Amelioration of anti-tuberculosis drug induced oxidative stress in kidneys bySpirulina fusiformisin a rat model

Abstract

Nephrotoxicity is a rare complication caused by anti-tuberculosis therapy-induced oxidative stress. The Cyanobacterium Spirulina fusiformis Voronikhin belonging to Oscillatoriaceae family is used traditionally as a source of antioxidants against oxidative stress. We aimed to investigate the efficacy of S. fusiformis in modifying isoniazid (INH) Histological examination of kidneys supported these findings. Results of the in silico analyses showed that selected active components of S. fusiformis interact with LXR and FXR and could be a possible mechanism of action. S. fusiformis rendered protection against anti-tuberculosis drugsinduced oxidative stress in kidney tissues of rats. ARTICLE HISTORY

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

“…Spirulina fusiformis (400 mg/kg b.w.) was administrated orally for 28 days (Chen et al 2005;Erejuwa et al 2011b;Martin and Sabina 2016).…”

Phycobiliproteins and phycocyanin of Arthrospira maxima (Spirulina) reduce apoptosis promoters and glomerular dysfunction in mercury-related acute kidney injury

“…It has been observed that Spirulina has a nephroprotective action against drug or toxicant that causes oxidative stress and renal damage. 9,15,16 Despite the benefits to renal health by Spirulina , there is not enough information about the effect of Spirulina on HgCl 2 -related glomerular and tubular renal dysfunction in AKI, although it has been reported that Spirulina and its components as phycobiliproteins and phycocyanin can reduce renal dysfunction in chronic kidney disease. 8 This work aimed to investigate whether phycobiliproteins and phycocyanin of Spirulina can improve HgCl 2 -related glomerular and tubular renal dysfunction as well as apoptosis process in kidney of rats.…”

Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti‐tuberculosis drug‐induced liver injury in a Western Chinese population

“…Combination regimens of anti‐TB drugs could induce cytolysis and cholestasis 33. Although Sherry et al and Guo et al showed that this phenomenon might be related to FXR,18,34 the specific mechanism remained unclear. We suspected that UGT2B4 might involve, which led us to conduct this investigation.…”