Absence of significant association between
            <i>UGT2B4</i>
            genetic variants and the susceptibility to anti‐tuberculosis drug‐induced liver injury in a Western Chinese population

Chen, Hao; Jiao, Lin; Zhou, Juan; Bai, Hao; Lyu, Mengyuan; Wu, Tao; Wu, Lijuan; Song, Jiajia; Liu, Tangyuheng; Hong, Yan; Ying, Binwu

doi:10.1111/jcpt.13132

Cited by 1 publication

(6 citation statements)

References 29 publications

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“…Only four studies performed causality assessment of AT-DILI [ 15 , 20 – 22 ]. In terms of DILI criteria, 10 studies used alanine aminotransferase (ALT) > 2 upper limit of normal (ULN) [ 3 , 15 , 18 – 20 , 22 , 23 , 29 – 31 ], one used ALT >3 ULN [ 32 ], and one used ALT >5 ULN [ 21 ]. The primary characteristics of the included studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Five other genes in the UGT family with 14 SNPs (UGT1A3: rs2008584 and rs6431625; UGT1A4: rs2011404; UGT1A6: rs6759892, 308C/A, and rs2070959; UGT1A7: rs17868323, rs17868324, and rs11692021; and UGT2B4: rs1131878, rs1966151, rs28361541, rs4557343, and rs79407331) were reported in five studies among Korean [ 18 ] or Chinese patients [ 3 , 22 , 29 , 30 ]. Seven SNPs were associated with AT-DILI risk in Chinese anti-TB treatment patients.…”

Section: Resultsmentioning

confidence: 99%

“…Ten, 23 full texts were carefully assessed for eligibility after screening the titles and abstracts. Finally, 12 eligible studies describing the relationship between UGTs polymorphisms and susceptibility to AT-DILI were included in the present study [3,15,[18][19][20][21][22][23][29][30][31][32]. A total of 32 SNPs in the seven UGT genes (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT2B4, and UGT2B7) were reported in 12 studies (including 6466 patients (2128 AT-DILI cases and 4338 controls)).…”

Section: Study Identifcation and Characteristicsmentioning

confidence: 99%

“…At least 85% of drug-susceptible TB patients are successfully treated [ 2 ]. However, anti-TB therapy is known to have a hepatotoxicity effect, and anti-TB drug-induced liver injury (DILI) (AT-DILI) has been a long-standing concern in the treatment of TB infection [ 3 ]. The reported incidence of AT-DILI varies widely from 2% to 28% in different countries, depending on the investigators' definition of DILI as well as the population being studied [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the SNP rs4148323 AA genotype of UGT1A1 was found to significantly reduce the risk of AT-DILI in Chinese patients in one study [ 21 ], while it was not associated with AT-DILI in Chinese patients in another study [ 20 ]. In recent years, the relationships between SNPs in other UGT genes (UGT1A4 [ 22 ], UGT2B4 [ 3 ], and UGT2B7 [ 23 ]) and AT-DILI risk have also been reported. Therefore, it is necessary to conduct a comprehensive systematic review by retrieving all publications reporting the relationship between SNPs in UGT genes and the risk of AT-DILI and clarifying the pooled effects of polymorphisms for AT-DILI.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

Chen,

Hao,

Wang

et al. 2023

Journal of Tropical Medicine

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Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver injury (AT-DILI). The relationship between UGTs polymorphisms and AT-DILI risk has been reported but with inconsistent results. We conducted a systematic review and meta-analysis to summarize the previous study results and evaluate the precise relationships. Methods. The PRISMA statement was strictly followed, and the protocol was registered in PROSPERO (CRD42022339317). The PICOS framework was used: patients received antituberculosis treatment, UGTs polymorphisms (mutants), UGTs polymorphisms (wild), AT-DILI, and case-control studies. Eligible studies were searched through nine databases up to April 27, 2022. The study’s qualities were assessed by the revised Little’s recommendations. Meta-analysis was conducted with a random-effects model using odds ratios (ORs) with 95% confidence intervals (95% CIs) as the effect size. Results. Twelve case-control studies with 2128 cases and 4338 controls were included, and 32 single nucleotide polymorphisms (SNPs) in the seven UGT genes have been reported in Chinese and Korean. All studies were judged as high quality. The pooled results indicated that UGT1A1 rs3755319 (AC vs. AA, OR = 1.454, 95% CI: 1.100–1.921, P = 0.009), UGT2B7 rs7662029 (G vs. A, OR = 1.547, 95% CI: 1.249–1.917, P < 0.0001; GG + AG vs. AA, OR = 2.371, 95% CI: 1.779–3.160, P < 0.0001; AG vs. AA, OR = 2.686, 95% CI: 1.988–3.627, P < 0.0001), and UGT2B7 rs7439366 (C vs. T, OR = 0.585, 95% CI: 0.477–0.717, P < 0.0001; CC + TC vs. TT, OR = 0.347, 95% CI: 0.238–0.506, P < 0.0001; CC vs. TC + TT, OR = 0.675, 95% CI: 0.507–0.898, P = 0.007) might be associated with the risk of AT-DILI. Conclusions. The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion should be interpreted with caution due to the low number of studies and the relatively small sample size.

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