Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
Xinyu Chen,
Zhuolu Hao,
Nannan Wang
et al.
Abstract:Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver injury (AT-DILI). The relationship between UGTs polymorphisms and AT-DILI risk has been reported but with inconsistent results. We conducted a systematic review and meta-analysis to summarize the previous study results and evaluate the precise relationships. Methods. The PRI… Show more
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