Ameliorating Spinal Cord Injury in an Animal Model With Mechanical Tissue Resuscitation

Zheng, Zhenlin; Morykwas, Michael J.; Tatter, Stephen B.; Gordon, Stan; McGee, Maria P.; Green, Heather; Argenta, Louis C.

doi:10.1227/neu.0000000000001063

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Further, the use of methylprednisolone (MP) to reduce edema and ischemia is waning due to controversy over its beneficial and harmful effects (Braughler and Hall, 1982;Hall et al, 1984;Cayli et al, 2004;Rozet, 2008). Still other research has looked into the beneficial effects of hypertonic saline (Nout et al, 2009) and the use of a mechanical tissue resuscitation device (Zheng et al, 2015) to minimize histological damage.…”

Section: Introductionmentioning

confidence: 99%

Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury

Hale

Yonan

Batarseh

et al. 2020

Front. Bioeng. Biotechnol.

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Recent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restricted flow of cerebrospinal fluid (CSF) in the subarachnoid space and central canal and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. Here we developed a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site. Tests were performed in 4-h studies immediately following severe (250 kD) contusion at T8 in rats using the OTD. A 3-h treatment with the OTD after 1-h post injury significantly reduced spinal cord edema compared to injured controls. A first approximation mathematical interpretation implies that this modest reduction in edema may be significant enough to relieve compression of local vasculature and restore flow of CSF in the region. In addition, we determined the progression of edema up to 28 days after insult in the rat for the same injury model. Results showed peak edema at 72 h. These preliminary results suggest that incorporating the OTD to operate continuously at the site of injury throughout the critical period of edema progression, the device may significantly improve recovery following contusion spinal cord injury.

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Section: Introductionmentioning

confidence: 99%

Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury

Hale

Yonan

Batarseh

et al. 2020

Front. Bioeng. Biotechnol.

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The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection

Webb

2017

Orthopedic Clinics of North America

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Suppression of Serum Prolactin Levels after Sports Concussion with Prompt Resolution Upon Independent Clinical Assessment To Permit Return-to-Play

Fountaine

Toda

Testa

et al. 2016

Journal of Neurotrauma

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A significant outflow of neurotransmitters and metabolites with associated enhanced cortical excitation occurs after concussive head trauma. Cellular changes in the acute post-injury period cannot be observed directly in humans, and as such, require indirect evidence from systems sufficiently sensitive to central neuronal cellular excitation. Dopamine is a neurotransmitter with numerous targets in the central and peripheral nervous system. Changes to central dopaminergic tone result in reciprocal responses to the level of serum prolactin (PRL). Thus, a concussion may lead to abnormal dopaminergic tone, resulting in dynamic perturbations in the serum PRL concentration. To determine the effect of concussion on serum PRL concentrations, venipuncture was performed in the morning in four male intercollegiate athletes (age, 20 ± 1 years; height, 71 ± 5 inches; weight, 174 ± 21 pounds) within 48 h of concussion and again at 7 and 14 days post-injury. Serum PRL concentrations for each visit were categorized by quartile within the normal range. In all athletes, serum PRL concentrations increased from the lower quartiles in samples obtained closer to the time of injury to the higher quartiles at 14 days post-injury. These serum PRL changes accompanied the resolution of symptoms and the clinical decision to permit return-to-play. It may be postulated that transient augmentation of central dopaminergic tone resulted in inhibition of PRL secretion early after concussion and that disinhibition of PRL release occurred when central dopaminergic tone subsequently returned to baseline levels. This novel observation provides evidence for dopaminergic dysfunction after concussion that may be tracked by determination of serum PRL levels.

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Ameliorating Spinal Cord Injury in an Animal Model With Mechanical Tissue Resuscitation

Cited by 5 publications

References 35 publications

Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury

Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury

The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection

Suppression of Serum Prolactin Levels after Sports Concussion with Prompt Resolution Upon Independent Clinical Assessment To Permit Return-to-Play

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