The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection

Webb, Lawrence X.

doi:10.1016/j.ocl.2016.12.004

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Patients with long-term wound disunion require a long period of inactivity due to the prolonged course of the condition. Thus, lower-limb DVT is more likely to occur (4). Therefore, accelerating the wound healing process and promoting the recovery of patients with OT may have a significant impact to reduce infection and lower-limb DVT.…”

Section: Introductionmentioning

confidence: 99%

Effects of vacuum sealing drainage to improve the therapeutic effect in patients with orthopedic trauma and to reduce post‑operative infection and lower‑limb deep venous thrombosis

Zhang

Zhao

et al. 2020

Exp Ther Med

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The present study investigated the effects of vacuum sealing drainage (VSD) to improve the therapeutic efficacy in patients with orthopedic trauma (OT) and reduce post-operative infection and lower-limb deep venous thrombosis (DVT) through a retrospective analysis. A total of 76 patients with OT treated at our hospital were selected for observation. The patients were divided into the control group (CG; n=37) and the experimental group (EG; n=39) according to the treatment administered. For patients in the CG, routine dressing changes were applied. Patients in the EG underwent VSD treatment. The dressing change frequency, time between the first and second operation, hospital stay, treatment efficacy, wound healing time, interleukin-6 (IL-6) serum level, tumor necrosis factor-α (TNF-α) serum level, incidence of post-operative infection and incidence of lower-limb DVT were compared between the two groups. The dressing change frequency in the EG was less than that in the CG. The time between the first and second operation and hospital stay were shorter in the EG than in the CG (P<0.05). The total effective rate in the EG was 97.44%, which was higher than that in the CG (78.38%; P<0.05). The wound healing time in the EG was 1.72±0.73 weeks and shorter than that in the CG (2.23±0.85 weeks; P<0.05). With the progression of treatment, the serum IL-6 and TNF-α levels decreased in the two groups, but the levels in the EG were lower than those in the CG (P<0.05). The incidence of post-operative infection and lower-limb venous thrombosis in the EG were 7.69 and 0.00%, respectively, and lower than those in the CG (27.03 and 13.01%, respectively; P<0.05). In the treatment of OT, VSD may reduce the dressing change frequency, shorten the operation time and hospital stay, accelerate wound healing and reduce post-operative infection and lower-limb DVT. Thus, the VSD treatment method is worthy of promotion and implementation in clinic.

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Section: Introductionmentioning

confidence: 99%

Effects of vacuum sealing drainage to improve the therapeutic effect in patients with orthopedic trauma and to reduce post‑operative infection and lower‑limb deep venous thrombosis

Zhang

Zhao

et al. 2020

Exp Ther Med

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“…NPWT is a beneficial technique for the removal of necrotic tissue fragments from a wound, as well as the efficient drainage of wound exudate, which can expedite wound healing (Duan et al, 2020). Evidence suggests that NPWT is a successful treatment for bone infection, with wound healing and infection healing times drastically reduced in comparison to traditional dressings (Webb, 2017); Dates from reports demonstrates that the use of Negative Pressure Wound Therapy to treat spinal infection in the infected intervertebral space and abscess is both safe and effective (Wang et al, 2022;Xing et al, 2022). By combining XLIF and NPWT, the shortcomings of traditional open surgery and endoscopic minimally invasive surgery can be effectively addressed in patients with spinal infection complicated complex conditions.…”

Section: Discussionmentioning

confidence: 99%

Case Report: A spinal infection with bilateral psoas abscesses was treated with NPWT to enhance the local infection by increasing the infiltration of neutrophil cells and draining the pus

Chang

2023

Front. Cell. Infect. Microbiol.

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Treatment of spinal brucellosis with bilateral psoas abscess is a challenging clinical endeavor. We retrospectively evaluated a case of lumbar infection and bilateral psoas abscess, and was effectively managed through a unilateral extreme lateral approach with the aid of NPWT for bilateral drainage. We hypothesize that NPWT can influence the Piezo1 receptor of neutrophils and further influence the interaction between neutrophils and endothelial cells to promote the clearance of infected lesions, and this phenomenon is also observed in pathological slides. This proves that NPWT can rapidly enhance the recruitment of neutrophils in the infected area and improve the local immune response, and after a year of reassessment and tracking, Bilateral drainage using NPWT via a unilateral Extreme Lateral Approach could acquire satisfactory surgical outcomes, can be used as a treatment modality for lumbar infection with bilateral psoas abscesses.

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“…Perfect wound repair remains the ultimate goal of scientists and clinicians, especially plastic surgeons. Traditional medicine to tissue engineering therapy provide potential mechanisms for wound repair and reconstruction 5,6 . However, there are no standard treatment guidelines for refractory wounds, and a systematic and effective treatment remains a problem to be solved.…”

Section: Introductionmentioning

confidence: 99%

Clinical observation of ultraviolet therapy combined with autologous platelet‐rich plasma in the treatment of chronic refractory wounds

Li,

Liu,

Tan

et al. 2024

International Wound Journal

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Refractory wounds present complex and serious clinical dilemmas in plastic and reconstructive surgeries. Currently, there are no standard guidelines for the treatment of refractory wounds. To observe the clinical effects of ultraviolet (UV) therapy combined with autologous platelet‐rich plasma (PRP) on chronic refractory wounds. Between January 2021 and December 2022, 60 inpatients with chronic refractory wounds were enrolled. Twenty patients were assigned to each of control groups 1 and 2 and treatment group according to whether they received PRP or UV treatment. All the patients underwent thorough debridement. Control group 2 received UV radiation. The treatment group underwent UV radiation combined with PRP gel covering the wound. Control group 1 underwent routine dressing changes after surgery, followed by skin grafting or skin key transfer if needed. One month later, we observed the wound healing in the two groups. After 2—4 PRP gel treatments, the wounds of patients in the treatment group healed. The healing time was 25.25 ± 4.93 days, and the dressings were changed 4.15 ± 3.30 times, both of which were better outcomes than in both control groups. In the treatment group, epidermal growth factor (EGF), insulin‐like growth factor (IGF), platelet‐derived growth factor (PGF), and transforming growth factor β (TGF‐β) were slightly higher, and the concentration of vascular endothelial growth factor (VEGF) was significantly higher than in the control group (p < 0.05). PRP combined with UV therapy significantly increased the concentration of wound growth factors, accelerated wound healing, shortened treatment time, reduced treatment costs, and alleviated pain in patients.

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The Impact of Negative Pressure Wound Therapy on Orthopaedic Infection

Cited by 11 publications

References 35 publications

Effects of vacuum sealing drainage to improve the therapeutic effect in patients with orthopedic trauma and to reduce post‑operative infection and lower‑limb deep venous thrombosis

Effects of vacuum sealing drainage to improve the therapeutic effect in patients with orthopedic trauma and to reduce post‑operative infection and lower‑limb deep venous thrombosis

Case Report: A spinal infection with bilateral psoas abscesses was treated with NPWT to enhance the local infection by increasing the infiltration of neutrophil cells and draining the pus

Clinical observation of ultraviolet therapy combined with autologous platelet‐rich plasma in the treatment of chronic refractory wounds

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