Ameliorating Potential of Quercetin on Liver Function, Genotoxicity and Oxidative Damage Induced by 2,3,7,8- Tetrachlorodibenzo-P-Dioxin in Liver of Male Rats

Abdulkareem, Saman Muhsin; Nanakali, Nadir Mustafa Qadir

doi:10.17582/journal.pjz/20190708100752

Cited by 2 publications

(11 citation statements)

References 30 publications

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“…The most important finding of this study is that TCDD induces cardiotoxicity by inducing oxidative damage and histological changes, and treatment with QUE can improve these harmful effects, which is consistent with previous reports (2,9,21). Our results indicated that the weight of the body and heart in the TCDD group changed which is in agreement with previous studies (2,22). These studies showed that TCDD decreased the weight of the body, testicular and liver.…”

Section: Discussionsupporting

confidence: 93%

“…It is possible that the improvement in body weight and heart weight after consuming QUE can be due to improve the liver damage from TCDD (21). Our results also showed that TCDD induced oxidative stress and histological changes in heart which is in agreement with previous studies (2,5,7,9,21,22). The TCDD induces oxidative stress and histological changes in heart and liver tissues.…”

Section: Discussionsupporting

confidence: 92%

“…TCDD is a ubiquitous environmental pollutant that can adversely and biochemically affect animals and humans. Evidence from in vivo studies showed that acute and chronic exposure to TCDD causes hepatotoxicity, immunotoxicity, reproductive dysfunction, carcinogenesis and cardiotoxicity (2)(3)(4)(5)(6)(7)(8). Ciftci et al, (2013a) showed that TCDD (2 μg/kg) causes oxidative damage and histological changes in heart of rat (9).…”

Section: Introductionmentioning

confidence: 99%

“…Increased expression of CYP1A and CYP1B genes by Interaction of TCDD with AHr causes the production of reactive oxygen/ nitrogen species (13). Increasing the production of oxidants, especially reactive oxygen/nitrogen species, and reducing the antioxidants content, known as oxidative stress, have recently attracted a great deal of attention (12) and it is known as one of the basic mechanisms of toxicity induced by TTDD in many tissues such as liver and testis (2,3). It has been shown that TCDD induces oxidative stress by enhancing lipid peroxidation, decreasing glutathione (GSH) content and misbalancing antioxidant enzymes in the liver and heart.…”

Section: Introductionmentioning

confidence: 99%

“…Quercetin (3,5,7,3',4'-pentahydroxyflavone, QUE) is a plant-derived compound such as onion, grape, nuts, tea, berries, cabbage, and cauliflower that has many medicinal properties. QUEacts an antagonist for AHr activated by TCDD (2,3). It shows a variety of biological effects, including antioxidants, lowering blood pressure (BP) and alleviating diseases associated with hyperglycemia, as shown in animal models and to some extent in humans.…”

Section: Introductionmentioning

confidence: 99%

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Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats

Nanakali

2020

Cell Mol Biol (Noisy-le-grand)

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The purpose of this study was to evaluate the prophylactic effects of quercetin (QUE) against oxidative damages and histological changes induced by 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin (TCDD) in rat heart. For this purpose, 20 adult male Wistar rats were divided into four groups as fellow control group, TCDD group (10µg/kg BW/day by gavage daily for 60 consecutive days), QUE group (30 mg/kg BW/day) and TCDD + QUEgroup. The oxidative biomarkers of heart tissue and the levels of cTnI and lipid profile in serum were measured. Our results showed that the cTnI serum level and the heart lipid peroxidation significantly increased and the heart level of antioxidant profile significantly decreased in the TCDD group compared to control and QUEgroups. While pretreatment with QUEcould significantly improved these factors in serum and heart tissue in animals that consumed TCDD. It can be concluded that QUEat doses of 30 mg/kg/day could alleviate heart oxidative damage and histological changes induced by TCDD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats

Nanakali

2020

Cell Mol Biol (Noisy-le-grand)

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Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

Abo‐EL‐Sooud

Abd‐Elhakim

Hashem

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to evaluate the probable ameliorative role of quercetin (QCN) against oxidative hepatotoxicity induced by aluminum oxide nanoparticles (Al2O3NPs) with a diameter < 30 nm and lead acetate (Pb) co-exposure in adult male Sprague–Dawley rats. Rats were weighed and allocated to seven groups (n = 10 each) and were treated orally via orogastric gavage for 60 successive days: rats of the 1st group were kept as control given distilled water (1 ml/kg), rats of the 2nd group received 2 ml/kg BW/day corn oil; rats of the 3rd group were administered 20 mg/kg BW QCN/day; rats of the 4th group received 100 mg/kg BW Al2O3NPs; rats of the 5th group received 50 mg/kg BW Pb; rats of the 6th group co-received Al2O3NPs and Pb at the same previous doses; and rats of the 7th group were co-administered Al2O3NPs, Pb, and QCN at the same previous doses. At the end of the experiment, serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total, direct, indirect bilirubin, triglycerides, total cholesterol, HDL, VLDL, and LDL were estimated. The hepatic oxidative stress biomarkers as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPx), were also evaluated. Finally, the histopathological and histomorphometric evaluations and the residues of Al and Pb in hepatic tissues were assessed. Al2O3NPs and/or Pb exposure significantly elevated lipid peroxidation levels and considerably altered the hepatic biochemical parameters; nevertheless, QCN significantly reduced hepatic enzymes compared to toxicant exposed groups. Additionally, QCN significantly improved Al2O3NPs-afforded liver tissue damage, as established in microscopic findings on the liver in the group treated with Al2O3NPs + Pb. Conclusively, QCN could be a candidate natural agent to safeguard the liver versus the co-harmful impacts of Al2O3NPs and Pb toxicity.

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Ameliorating Potential of Quercetin on Liver Function, Genotoxicity and Oxidative Damage Induced by 2,3,7,8- Tetrachlorodibenzo-P-Dioxin in Liver of Male Rats

Cited by 2 publications

References 30 publications

Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats

Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats

Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

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