Ameliorating effects of Juzentaihoto on restraint stress and P. gingivalis-induced alveolar bone loss

Takeda, Orie; Toyama, Toshizo; Watanabe, Koichi; Sato, Takenori; Sasaguri, Kenichi; Akimoto, Susumu; Sato, Sadao; Kawata, Toshitsugu; Hamada, Naoki

doi:10.1016/j.archoralbio.2014.06.010

Cited by 15 publications

(14 citation statements)

References 45 publications

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“…Regarding the anti-inflammatory property of Kampo formulas, Rikkosan has been reported to inhibit both IL-1β and PGE2 production (26). Moreover, Shosaikoto decreases LPS-induced PGE2 production through inhibition of both cyclogenase -2 expression and activity (5), while Juzentaihoto effectively inhibits restraint stress and osteoclastogenesis involved in periodontal tissue destruction (27). Lastly, we also showed in a previous study that Rokumigan inhibits the IL-6 secretion by LPS-stimulated gingival epithelial cells and fibroblast, in addition to promote wound healing in a fibroblast model (6).…”

Section: Discussionsupporting

confidence: 52%

Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

et al. 2018

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Objective : The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Methods : Twenty -three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups : 7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. Results : No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the control group (p!0.05). No such differences were observed for the group receiving Hangeshashinto. Conclusion : This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer.

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Section: Discussionsupporting

confidence: 52%

Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

et al. 2018

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“…Very few studies of the beneficial effect of Kampo medicines on periodontal disease have been published. Shosaikoto (TJ-9) and Orento (TJ-120) have been shown to suppress lipopolysaccharide (LPS)-induced prostaglandin E 2 production by human gingival fibroblasts [ 6 , 7 ], while Juzentaihoto (TJ-48) inhibits osteoclast differentiation in vitro and reduces alveolar bone loss in a rat periodontitis model [ 8 ]. In a recent study, we showed that Rokumigan (TJ-87) promotes wound healing in a gingival fibroblast model, attenuates pro-inflammatory cytokine secretion by oral mucosal cells, and prevents biofilm formation by Fusobacterium nucleatum [ 9 ], a bacterial species that plays an important role in bridging commensal Gram-positive “early colonizers” and the periodontopathogenic Gram-negative “late colonizers” in subgingival biofilm [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Daiokanzoto (TJ-84) Kampo Formulation Reduces Virulence Factor Gene Expression in Porphyromonas gingivalis and Possesses Anti-Inflammatory and Anti-Protease Activities

et al. 2016

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Kampo formulations used in Japan to treat a wide variety of diseases and to promote health are composed of mixtures of crude extracts from the roots, bark, leaves, and rhizomes of a number of herbs. The present study was aimed at identifying the beneficial biological properties of Daiokanzoto (TJ-84), a Kampo formulation composed of crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, with a view to using it as a potential treatment for periodontal disease. Daiokanzoto dose-dependently inhibited the expression of major Porphyromonas gingivalis virulence factors involved in host colonization and tissue destruction. More specifically, Daiokanzoto reduced the expression of the fimA, hagA, rgpA, and rgpB genes, as determined by quantitative real-time PCR. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to evaluate the anti-inflammatory properties of Daiokanzoto. Daiokanzoto attenuated the P. gingivalis-mediated activation of the NF-κB signaling pathway. It also reduced the secretion of pro-inflammatory cytokines (IL-6 and CXCL8) by lipopolysaccharide-stimulated oral epithelial cells and gingival fibroblasts. Lastly, Daiokanzoto, dose-dependently inhibited the catalytic activity of matrix metalloproteinases (-1 and -9). In conclusion, the present study provided evidence that Daiokanzoto shows potential for treating and/or preventing periodontal disease. The ability of this Kampo formulation to act on both bacterial pathogens and the host inflammatory response, the two etiological components of periodontal disease, is of high therapeutic interest.

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“…Commercially pure titanium (Ti) is increasingly becoming the preferred option for replacing missing teeth, and occupies the largest market share in the oral metal materials/implants sector 1 . As regards bacterial diversity in an individual oral cavity this is represented by approximately 500 species, which can readily colonize different types of surfaces including teeth, prosthetic devices and dental implants 2 3 4 . The formation and maturation of biofilms on dental implant material surfaces may lead to the development of peri-implant diseases, such as peri-implant mucositis or peri-implantitis, influencing the long term success of the teeth implant 5 6 7 .…”

mentioning

confidence: 99%

Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis

Memarzadeh

Chang

et al. 2016

Sci Rep

184

112

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Formation of bacterial biofilms on dental implant material surfaces (titanium) may lead to the development of peri-implant diseases influencing the long term success of dental implants. In this study, a novel Cu-bearing titanium alloy (Ti-Cu) was designed and fabricated in order to efficiently kill bacteria and discourage formation of biofilms, and then inhibit bacterial infection and prevent implant failure, in comparison with pure Ti. Results from biofilm based gene expression studies, biofilm growth observation, bacterial viability measurements and morphological examination of bacteria, revealed antimicrobial/antibiofilm activities of Ti-Cu alloy against the oral specific bacterial species, Streptococcus mutans and Porphyromonas gingivalis. Proliferation and adhesion assays with mesenchymal stem cells, and measurement of the mean daily amount of Cu ion release demonstrated Ti-Cu alloy to be biocompatible. In conclusion, Ti-Cu alloy is a promising dental implant material with antimicrobial/antibiofilm activities and acceptable biocompatibility.

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Ameliorating effects of Juzentaihoto on restraint stress and P. gingivalis-induced alveolar bone loss

Cited by 15 publications

References 45 publications

Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition

The Daiokanzoto (TJ-84) Kampo Formulation Reduces Virulence Factor Gene Expression in Porphyromonas gingivalis and Possesses Anti-Inflammatory and Anti-Protease Activities

Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis

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