Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis

Li, Rui; Memarzadeh, Kaveh; Chang, Bei; Zhang, Yumei; Ma, Zheng; Allaker, Robert P.; Ren, Ling; Yang, Ke

doi:10.1038/srep29985

Cited by 178 publications

(121 citation statements)

References 39 publications

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“…Nevertheless, bacterial biofilms on titanium surfaces can also develop, such as those formed by the oral cavity microbiome on dental implants frequently leading to peri-implant diseases [67]. Therefore, some modifications of Ti surfaces are proposed to decrease the extent of their colonization by microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity Studies on Titania Coatings and the Estimation of Their Usefulness in the Modification of Implant Surfaces

et al. 2017

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Morphologically different titania coatings (nanofibers (TNFs), nanoneedles (TNNs), and nanowires (TNWs)) were studied as potential biomedical materials. The abovementioned systems were produced in situ on Ti6Al4V substrates via direct oxidation processes using H2O2 and H2O2/CaCl2 agents, and via thermal oxidation in the presence of Ar and Ar/H2O2. X-ray diffraction and Raman spectroscopy have been used to structurally characterize the produced materials. The morphology changes on the titanium alloy surface were investigated using scanning electron microscopy. The bioactivity of the samples has been estimated by the analysis of the produced titania coatings’ biocompatibility, and by the determination of their ability to reduce bacterial biofilm formation. The photoactivity of the produced nanocoatings was also analyzed, in order to determine the possibility of using titania coated implant surfaces in the sterilization process of implants. Photocatalytic activity was estimated using the methylene blue photodegradation kinetics, in the presence of UV light.

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Section: Discussionmentioning

confidence: 99%

Bioactivity Studies on Titania Coatings and the Estimation of Their Usefulness in the Modification of Implant Surfaces

et al. 2017

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“…The energy dispersive spectrometer (EDS) and X‐ray photoelectron spectroscopy (XPS) confirmed successful scaffold modification with the coating (Figure 1c). The ion release experiment results show that the TiCu/Ti‐Cu‐N coating maintains a uniform micro‐release throughout the release process, and the release is much lower than the recommended daily intake of the World Health Organization (2–3 mg) . (Figure 1d).…”

Section: Resultsmentioning

confidence: 97%

Functionalized TiCu/Ti‐Cu‐N‐Coated 3D‐Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

Ren

Xie

et al. 2020

Adv Materials Inter

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Ti6Al4V scaffolds have high strength and corrosion resistance. 3D printing technology can optimize the pore structure of Ti6Al4V scaffolds, promoting bone tissue growth into the scaffolds to form firm osseointegrations. However, Ti6Al4V lacks biological activity. This defect can be overcome through surface modifications. Arc ion plating is employed to prepare titanium copper/titanium copper nitride (TiCu/Ti‐Cu‐N) multilayer coating, which is applied to 3D‐printed porous Ti6Al4V scaffolds by selective laser melting and bearing 300–400 µm pores. In addition to the excellent biological activity of copper, TiN shows superior corrosion resistance. The scaffold properties, osteogenesis, and osteointegration are evaluated in vitro and in vivo. Results show that human bone mesenchymal stem cells (hBMSCs) proliferate and adhere more effectively on coated scaffolds than on uncoated scaffolds. Further, the coating has a significant role in recruiting hBMSCs, and upregulation of the SDF‐1α/CXCR4 axis, p38 expression, and extracellular signal‐related kinase (Erk) and Akt signaling pathway. The in vitro results are further confirmed by an animal experiment in the New Zealand white rabbit femur tibia defect. Overall, the TiCu/Ti‐Cu‐N‐coated 3D‐printed Ti6Al4V scaffold shows excellent biocompatibility and bioactivity in promoting bone repair. The underlying mechanism may involve recruiting BMSCs and promoting their osteogenic differentiation.

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“…Previous studies have demonstrated that Cu bearing alloys, such as Ti-Cu alloys2728, Ti-6Al-4V-5Cu alloys29 have strong antibacterial properties. The possible antibacterial mechanism of Ti‒Ni‒Cu alloys (illustrated in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The possible antibacterial mechanism of Ti‒Ni‒Cu alloys (illustrated in Fig. 8(C)) is as follows: firstly, the Cu 2+ released from Ti‒Ni‒Cu alloys; and then enhance the permeability of the bacterial cell membrane, with intracellular material leakage leading to cellular lysis830; it further causes the generation of reactive oxygen species, protein oxidation and DNA degradation in bacteria cells, thus result in the death of bacteria828.…”

Section: Discussionmentioning

confidence: 99%

Design and development of novel antibacterial Ti-Ni-Cu shape memory alloys for biomedical application

Qiu

Zhou

et al. 2016

Sci Rep

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In the case of medical implants, foreign materials are preferential sites for bacterial adhesion and microbial contamination, which can lead to the development of prosthetic infections. Commercially biomedical TiNi shape memory alloys are the most commonly used materials for permanent implants in contact with bone and dental, and the prevention of infections of TiNi biomedical shape memory alloys in clinical cases is therefore a crucial challenge for orthopaedic and dental surgeons. In the present study, copper has been chosen as the alloying element for design and development novel ternary biomedical Ti‒Ni‒Cu shape memory alloys with antibacterial properties. The effects of copper alloying element on the microstructure, mechanical properties, corrosion behaviors, cytocompatibility and antibacterial properties of biomedical Ti‒Ni‒Cu shape memory alloys have been systematically investigated. The results demonstrated that Ti‒Ni‒Cu alloys have good mechanical properties, and remain the excellent shape memory effects after adding copper alloying element. The corrosion behaviors of Ti‒Ni‒Cu alloys are better than the commercial biomedical Ti‒50.8Ni alloys. The Ti‒Ni‒Cu alloys exhibit excellent antibacterial properties while maintaining the good cytocompatibility, which would further guarantee the potential application of Ti‒Ni‒Cu alloys as future biomedical implants and devices without inducing bacterial infections.

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Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis

Cited by 178 publications

References 39 publications

Bioactivity Studies on Titania Coatings and the Estimation of Their Usefulness in the Modification of Implant Surfaces

Bioactivity Studies on Titania Coatings and the Estimation of Their Usefulness in the Modification of Implant Surfaces

Functionalized TiCu/Ti‐Cu‐N‐Coated 3D‐Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

Design and development of novel antibacterial Ti-Ni-Cu shape memory alloys for biomedical application

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