Ameliorating effects of <i>Hericium erinaceus</i> polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide

Tian, Bin; Wang, Peiyi; Xu, Tao; Cai, Ming; Mao, Rongliang; Huang, Liangshui; Sun, Peilong; Yang, Kai

doi:10.1039/d2fo03769f

Cited by 9 publications

(4 citation statements)

References 57 publications

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“…Elevated MDA levels can interfere with antioxidant effects, contributing to liver cell degeneration and necrosis [29]. In contrast, GSH and SOD are essential components of the body's antioxidant system, playing a crucial role in protecting the liver against oxidative stress damage [39]. SOD, an antioxidant metalloenzyme, catalyzes the breakdown of superoxide anion radicals, converting reactive oxygen species into hydrogen peroxide, which is further decomposed into water by GSH.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies

Zhang,

Liu,

et al. 2024

Foods

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Histamine, a bioactive component in certain foods such as Huangjiu has been associated with liver injury and disrupted intestinal balance. This study explored the potential therapeutic effects of fucoidan (FCD) in mitigating histamine-induced imbalances in mice. We found that FCD mitigated liver injury, reducing transaminases, oxidative stress, and inflammation. Histological improvements included decreased cell infiltration and necrosis. FCD restored tight junction proteins and suppressed inflammation-related genes. Western blot analysis revealed FCD’s impact on TGF-β1, p-AKT, AKT, CYP2E1, Grp78, NLRP3, Cas-1, and GSDMD. Gut LPS levels decreased with FCD. Gut microbiota analysis showed FCD’s modulation effect, reducing Firmicutes and increasing Bacteroides. FCD demonstrates potential in alleviating histamine-induced liver injury, regulating inflammation, and influencing gut microbiota. Further research exploring higher dosages and additional parameters is warranted.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies

Zhang,

Liu,

et al. 2024

Foods

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“…Der Einsatz des Hericium ist aufgrund verschiedener Wirkeigenschaften sehr gut zur Verbesserung des Magenmilieus geeignet. Die Traditionelle Chinesische Medizin (TCM) beschreibt ihn als magenstärkend, transformierend, klärend und verdauungsregulierend [1]. Er hat sich gut bewährt, um angegriffene Schleimhäute zu regenerieren und Entzündungen abzubauen.…”

Section: Therapeutische Effekte Verschiedener Vitalpilzeunclassified

“…Verbesserung des Darmmilieus: Aufbau des Mikrobioms, Anti-Leaky-Gut-Effekt Die Einnahme von Vitalpilzpulver übt grundsätzlich eine präbiotische Wirkung auf den Darm aus, denn durch die enthaltenen Pilz-Polysaccharide wird der Aufbau der physiologischen Mikrobiota gefördert [10]. Studien belegen für Hericium, dass sich unter seiner Gabe besonders solche Bakterien im Darm ansiedeln, die eine vermehrte Bildung kurzkettiger Fettsäuren wie Butyrat fördern [1]. Butyrat wird mit vielen positiven Effekten im Darm in Verbindung gebracht, u. a. Antiinflammation und Immunregulation.…”

Section: Therapeutische Effekte Verschiedener Vitalpilzeunclassified

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Magen-Darm-Erkrankungen mit Heil- und Vitalpilzen erfolgreich therapieren

Ogroske

2024

Erfahrungsheilkunde

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ZusammenfassungUngesunde Ernährung, ein hektischer, stressreicher Lebensstil, emotionale Belastungen, Bewegungsmangel sowie die Einnahme bestimmter Medikamente haben einen negativen Einfluss auf unsere Magen-Darm-Gesundheit. Völlegefühl, Blähungen, Reizdarm, Sodbrennen, Durchfälle oder auch anhaltende Verstopfung sind weit verbreitete Symptome, die die Lebensqualität der Betroffenen erheblich beeinträchtigen, insbesondere wenn sie sich chronifizieren. Darüber hinaus leiden viele Menschen in den modernen Gesellschaften unter schwerwiegenden Magen-Darm-Erkrankungen wie Morbus Crohn oder Colitis ulcerosa. Der Gesundheitszustand unseres Verdauungstraktes hat auch einen großen Einfluss auf unsere Gesamtgesundheit. Mit den in der Mykotherapie eingesetzten Vitalpilzen – sie werden synonym auch Heil- bzw. medizinisch wirksame Pilze genannt – steht eine effektive naturheilkundliche Therapieoption zur Verfügung. So leisten Vitalpilze einen wertvollen Beitrag zur Wiederherstellung und Erhaltung der Magen- und Darmgesundheit und einer intakten Verdauung. Ihr Einsatz hat sich bei der Behandlung einer Vielzahl von Magen-Darm-Erkrankungen bewährt.

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Dynamic changes in aromas and precursors of edible fungi juice: mixed lactic acid bacteria fermentation enhances flavor characteristics

Sun,

Du,

Yan

et al. 2024

J Sci Food Agric

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BACKGROUNDLactic acid bacteria (LAB) fermentation technology has been increasingly used in the deep processing of edible fungi. However, the flavor profiles of edible fungi products after mixed LAB fermentation have received less attention and how aromas changes during the mixed LAB fermentation are still open questions. In the present study, fermented Hericium erinaceus and Tremella fuciformis compound juice (FHTJ) was prepared by mixed LAB strains. We aimed to systematically monitor the dynamic changes of aromas and precursors throughout the fermentation process and a data‐driven association network analysis was used to tentatively illustrate the mechanisms of formation between aromas and their precursors.RESULTSMixed LAB fermentation could enrich the aroma profile of FHTJ, reducing the unpleasant flavors such as nonanal and 1‐octen‐3‐ol, as well as increasing the floral flavors such as ethyl acetate and α‐pinene. Partial least squares‐discriminant analysis and relative odor activity values revealed that 11 volatile chemicals were recognized as aroma‐active markers. Volcano plot analysis showed that 3‐octen‐2‐one (green flavor) was the key aroma‐active marker in each stage, which was down‐regulated in fermentation stages I, II and IV, whereas it was up‐regulated in stage III. 3‐Octen‐2‐one was significantly negatively correlated with organic acids, particularly pyruvate (r2 = −0.89). Ethyl caprylate (floral flavor) was up‐regulated in the late fermentation stage, and showed a negative correlation with sugar alcohols and a positive correlation with organic acids, especially tartaric acid (r2 = 0.96).CONCLUSIONThe present study demonstrates the beneficial effect of mixed LAB fermentation on flavor characteristics, providing guidance for fermented edible fungi juice flavor quality monitoring and control. © 2024 Society of Chemical Industry.

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Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide

Abstract: Hericium erinaceus is a kind of large fungus with rich nutrition, and its polysaccharides possess various biological activities. In recent years, widespread interests were focused on maintaining or improving intestinal...

Cited by 9 publications

References 57 publications

Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies

Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies

Magen-Darm-Erkrankungen mit Heil- und Vitalpilzen erfolgreich therapieren

Dynamic changes in aromas and precursors of edible fungi juice: mixed lactic acid bacteria fermentation enhances flavor characteristics

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