Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats

Saggu, Shalini; Sakeran, Mohamed I.; Zidan, Nahla; Tousson, Ehab; Mohan, Anand; Rehman, Hasibur

doi:10.1016/j.fct.2014.06.029

Cited by 134 publications

(83 citation statements)

References 38 publications

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“…In the present study, SOD activity was significantly reduced after exposure to 4-OP in the hepatocytes. This result agrees with a previous study reporting t-OP-induced liver injury and oxidative stress in male rats (Saggu et al 2014). The decrease in SOD activity is probably due to overproduction of superoxide radicals in the hepatocytes by 4-OP, which cause such an effect that the superoxide radicals, either by themselves or after their transformation to hydrogen peroxide, lead to oxidation of the cysteine in the enzyme and decreases the SOD activity (Dimitrova et al 1994).…”

Section: Discussionsupporting

confidence: 82%

Cytotoxic effects of 4-octylphenol on fish hepatocytes

Kaptaner

2015

Cytotechnology

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The present study was conducted to determine cytotoxic effects of 4-octylphenol (4-OP) on primary cultured hepatocytes of pearl mullet (Alburnus tarichi). Lactate dehydrogenase (LDH) release, malondialdehyde (MDA) level, antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST)] and glutathione (GSH) content were measured after 24-h exposure to 4-OP. 4-OP caused dose-and timedependent increases in LDH release. Significant induction of MDA level and decrease in GSH content were found. SOD and GPx activities were decreased while GST activity was increased. These findings suggest that 4-OP leads to cytotoxicity by depressing antioxidant defenses in fish hepatocytes.

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Section: Discussionsupporting

confidence: 82%

Cytotoxic effects of 4-octylphenol on fish hepatocytes

Kaptaner

2015

Cytotechnology

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“…The high-density liquid extract was dried at 37°C for 24 hours. The residual powder was used to formulate the Cichorium intybus L. hydroalcoholic extract doses (Saggu et al, 2014).…”

Section: Extractionmentioning

confidence: 99%

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

Khodadadi

Mousavinasab

Khamesipour

et al. 2016

Rev. Bras. Cienc. Avic.

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The use of compounds with antioxidant properties as a source of phelanoeid compounds is highly recommendable in the poultry industry. Therefore, the effect of Cichorium intybus L. herb on pathobiochemical indexes of chicken under heat stress was studied. After exposure to heat stress (from day 21 to day 42 of growth), hydroalcoholic extraction was provided to 270 broiler chicks randomly divided into six groups and placed in two distinct poultry houses (heat stress and normal conditions). The three groups were recipient group of Cichorium intybus L.(1); recipient group of vitamin C (2) and control group (3). The birds in one of the houses were exposed to heat stress conditions (35 °C for 8 hours) for a time period between 22 to 42 days and the birds in the other house were reared under normal conditions (20-22°C) for the same time period. Blood samples collected from the birds showed that Cichorium intybus L. herb caused significant decrease in uric acid, Triglyceride, Alanine aminotransferase (ALT), total body clearance factors (CL-factors) and right ventricular failure index (RVF) and significant increase in K + under heat stress condition (p<0.05). Vitamin C caused significant decrease in uric acid, ALT, CL-factors and RVF index and significant increase in K+ and Na+ under heat stress condition (p<0.05). A significant decrease in cholesterol and triglyceride in recipient group of Cichorium intybus L was observed compared to the recipient group of vitamin C under heat stress condition (p<0.05). In a pathologic examination normal observations were in recipient group of Cichorium intybus L and recipient group of vitamin C compared to the control group. According to this study, use of Cichorium intybus L extract and vitamin C in chicken under heat stress induced improvement in liver, kidney activity and fat metabolism.

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“…Various mechanisms might contribute to their antihyperglycemic property, these including: inhibition of carbohydrate digestion (by inhibiting alpha amylase and alpha glucosidase) and glucose absorption in the intestine; stimulation of insulin secretion from pancreatic-β-cells, modulation of signaling pathways and gene expression among others (Bahadoran et al, 2013). Although the total flavonoids content was relatively small, relative to the phenolic contents, it may also contribute to the antioxidative properties of the plant extract as suggested by Saggu et al (2014). Due to their redox abilities; these compounds contribute to the total antioxidant activities of GSMLE.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract

Ibrahim

Tijjani

Yusuf

et al. 2017

ESJ

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Some medicinal plants and their purified derivatives have demonstrated beneficial therapeutic potentials for many centuries. They have been reported to exhibit antioxidant activity, reducing the oxidative stress in cells and are therefore useful in the treatment of many human diseases, including diabetes and other non-communicable diseases. This study evaluated antioxidative activity and enzymatic (alpha-amylase and alphaglucosidase) inhibitory potentials of Gymnema sylvestre methanolic leaf extract (GSMLE) using standard methods. Phytochemical screening revealed the presence of alkaloids, tannins, saponins, steroids, terpenoids and flavonoids. The total phenolics and total flavonoids content in the extract were found to be 6.629±0.745 (µg/ml of catechol equivalent) and 0.004±0.0012 (µg/ml of quercetin equivalent) respectively. GSMLE was shown to have radical scavenging activity against DPPH (290.54 ± 39.72 %), hydroxyl radical (86.507 ± 23.55 %) and hydrogen peroxide (45.25 ± 25.23 %). The level of SOD was significantly decreased in H2O2 induced and European Scientific Journal December 2017 edition Vol.13, No.36 ISSN: 1857 -7881 (Print) e -ISSN 1857 219 H2O2+extract induced when compared with normal control (p<0.05); the level of GSH was significantly increased in H2O2 induced control and significantly decreased in H2O2+extract induced test when compared to normal control. GSH was also decreased significantly in H2O2+extract induced when compared to H2O2 induced control (p<0.05). The extract also demonstrated significant inhibition of alpha-glucosidase (IC50 182.26 ±1.05μg/ml) when compared with standard acarbose (IC50 189.52±0.46) and was more potent than the arcarbose on alpha-amylase inhibition with IC50 of 195.3±4.40 and 200.05±7.16 respectively. These findings may therefore, stress the potentiality of using Gymnema sylvestre as a natural remedy for the management of type 2 diabetes.

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Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats

Cited by 134 publications

References 38 publications

Cytotoxic effects of 4-octylphenol on fish hepatocytes

Cytotoxic effects of 4-octylphenol on fish hepatocytes

The Effect of Cichorium Intybus L. Ethanol Extraction on the Pathological and Biomedical Indexes of the Liver and Kidney of Broilers Reared Under Heat Stress

In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract

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