Ambulatory Blood Pressure Monitoring and Serum Nitric Oxide Concentration in Type 1 Diabetic Children

Horoz, Özden Özgür; Yüksel, Bilgin; Bayazıt, Aysun Karabay; Attila, Gulen; Sertdemır, Yaşar; Mungan, Neslihan; Topaloğlu, Ali Kemal; Özer, Güler

doi:10.1507/endocrj.k08e-338

Cited by 12 publications

(9 citation statements)

References 31 publications

(26 reference statements)

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“…Serum NO level was significantly increased in diabetic patients with than those without nephropathy which came in accordance to previous studies [35,36]. Prabhakar, [37] reported that the enhanced NO production may contribute to hyperfiltration and microalbuminuia at early diabetic nephropathy.…”

Section: Discussionsupporting

confidence: 90%

Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents

El-Samahy

Matter

Youssef

et al. 2013

J Diabetes Metab Disord

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BackgroundCarotid intima media thickness (CIMT) is a non invasive marker of subclinical atherosclerosis. Hyperglycemia, oxidatively modified atherogenic lipoproteins and advanced glycation end products are linked to increased oxidative stress in diabetes. We aimed to find out the relation between carotid intima media thickness in type 1 diabetic children and adolescents and plasma nitric oxide and total antioxidant capacity levels as markers of oxidative stress.MethodsThis study included 50 children and adolescents with type 1 diabetes mellitus with mean age (9.7 ± 3.4 years) and 50 healthy age and sex matched controls. They were subjected to assessment of hemoglobin A1c, total cholesterol and triglycerides, serum total antioxidant capacity, serum nitric oxide (NO) by colorimetric method and carotid intima media thickness by B-mode ultrasound.ResultsThere was significant elevation in serum nitric oxide (17.07 ± 6.4 vs 12.6 ± 4.7 μmol/L; p < 0.001), CIMT (0.47 ± 0.04 vs 0.39 ± 0.02 mm; p < 0.001) and significant reduction in serum total antioxidant capacity (0.41 ± 0.29 vs 0.87 ± 0.23 mmol/L; p < 0.001) in diabetic patients compared to controls. Carotid intima media thickness was correlated positively with nitric oxide (r = 0.402, p = 0.01) and negatively with total antioxidant capacity (r = -0.341, p = 0.02). Carotid intima media thickness was also correlated positively with age, duration of diabetes but not correlated with glycemic control or lipid profile.ConclusionThe significant elevation in nitric oxide and reduction in total antioxidant capacity in children and adolescents with type 1 diabetes mellitus with their correlation with carotid intima media thickness may reflect the role of oxidative stress in the development of atherosclerosis in young type 1 diabetic subjects.

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Section: Discussionsupporting

confidence: 90%

Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents

El-Samahy

Matter

Youssef

et al. 2013

J Diabetes Metab Disord

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“…6) [77,81,86,89,96]. When the meta-analysis was restricted to those studies conducted in diabetic children (n ¼ 148), the respective coefficient was r ¼ 0.51 (95% CI 0.22-0.81) [81,86,89]. More specifically, in one of these studies conducted in children with reflux nephropathy, 29% of the children had increased ambulatory BP load greater than 30% -mainly diastolic [96] -whereas in another study in diabetic children, 24% had increased ambulatory BP levels [86].…”

Section: Urine Albumin Excretionmentioning

confidence: 99%

“…However, the latter studies mainly included children with renal parenchymal hypertension which mainly involves DBP elevation [81,86,89,96]. However, the latter studies mainly included children with renal parenchymal hypertension which mainly involves DBP elevation [81,86,89,96].…”

Section: Studymentioning

confidence: 99%

Out-of-office blood pressure and target organ damage in children and adolescents

Κόλλιας

Dafni²,

Poulidakis³

et al. 2014

Journal of Hypertension

115

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“…However, while increased levels of NO production were detected in early diabetes, as the duration of diabetes increases, reduced blood NO concentrations were measured in diabetic patients (3,4,23,24,25). Accordingly, we found significantly higher plasma NO concentrations in both microalbuminuria and normoalbuminuria groups relative to the control group in the first decade of T1DM onset.…”

Section: Discussionmentioning

confidence: 99%

“…Several biomarkers and also radiological methods including measurement of flow-mediated dilatation (FMD) of the brachial artery and carotid intima media thickness (CIMT) have been used to assess diabetes-related early vascular alterations. Changes in the amount and/or bioavailability of nitric oxide (NO) molecule, the major agent that contributes to the anti atherosclerotic effects of endothelium, constitute one of the early findings of ED (1,2,3,4). …”

Section: Introductionmentioning

confidence: 99%

Soluble Endoglin Level Increase Occurs Prior to Development of Subclinical Structural Vascular Alterations in Diabetic Adolescents

Emeksiz

Bıdecı²,

Damar³

et al. 2016

Jcrpe

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Objective:Soluble endoglin (S-endoglin) has been implicated as a potential marker of endothelial dysfunction (ED) and was reported to be elevated in diabetic adults, correlating with the severity of diabetic vasculopathy. However, circulating S-endoglin and its association with other markers of ED have not been formerly analyzed in the first decade of diabetes onset in adolescents with type 1 diabetes mellitus (T1DM).Methods:Fifty-eight adolescents with moderately/poorly controlled T1DM were included in this study and twenty-nine healthy adolescents served as controls. The diabetic group was divided into two groups based on the presence of microalbuminuria, as the microalbuminuria group (n=15) and the normoalbuminuria group (n=43). Functional vascular alterations were evaluated by measuring serum S-endoglin and plasma nitric oxide (NO) concentrations, the flow-mediated dilatation (FMD) of the brachial artery. Carotid intima media thickness (CIMT) was measured for evaluation of structural vascular alterations.Results:The S-endoglin and NO levels of both microalbuminuria and normoalbuminuria groups were higher than those of the control group (for S-endoglin, p=0.047 and p<0.001; for NO, p=0.004 and p=0.006, respectively). The FMD percent was lower in the microalbuminuria group compared to the normoalbuminuria and control groups (p=0.036 and p=0.020, respectively). There were negative correlations between S-endoglin concentration and FMD percent (r=-0.213, p=0.051) and between serum S-endoglin concentration and albumin excretion rate (r=-0.361, p=0.005). No significant differences were found in CIMT among any of the groups (p=0.443).Conclusion:In adolescents with T1DM, S-endoglin concentrations might increase in parallel to the deterioration in endothelial function before subclinical structural vascular alterations become evident.

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Ambulatory Blood Pressure Monitoring and Serum Nitric Oxide Concentration in Type 1 Diabetic Children

Cited by 12 publications

References 31 publications

Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents

Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents

Out-of-office blood pressure and target organ damage in children and adolescents

Soluble Endoglin Level Increase Occurs Prior to Development of Subclinical Structural Vascular Alterations in Diabetic Adolescents

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