Ambulatory 24 hour sleep-wake monitoring in narcolepsy-cataplexy compared to matched controls

Broughton, Roger; Dunham, Wayne; Newman, Jody; Lutley, K.; Duschesne, P.; Rivers, Martin

doi:10.1016/0013-4694(88)90145-9

Cited by 124 publications

(46 citation statements)

References 11 publications

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“…In cases of well-characterized narcolepsy with cataplexy, PSG is still necessary for the diagnosis of comorbidities. 59 Interpretation of PSG findings The most frequent narcolepsy findings are: [60][61][62] • normal sleep efficiency in younger patients; • non-REM sleep latency below 10 minutes; • reduction of REM sleep latency below 70 minutes; • increased number of micro-arousals; • increased transitions between sleep and waking stages;…”

Section: Narcolepsy Secondary To Medical or Neurological Illnessesmentioning

confidence: 99%

Diretrizes brasileiras para o diagnóstico de narcolepsia

Alóe

Alves

Araújo

et al. 2010

Rev. Bras. Psiquiatr.

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Este artigo relata as conclusões da reunião de consenso com médicos especialistas sobre diagnóstico de narcolepsia baseada na revisão dos artigos sobre narcolepsia listados no Medline entre 1980 e 2010. A narcolepsia é uma doença crônica de início entre a primeira e segunda décadas de vida do indivíduo. Os sintomas essenciais são cataplexia e sonolência excessiva. A cataplexia é definida como episódios súbitos, recorrentes e reversíveis de fraqueza da musculatura esquelética desencadeados por situações de conteúdo emocional. Os sintomas acessórios são alucinações hipnagógicas, paralisia do sono e sono fragmentado. Critérios de diagnóstico clínico de acordo com a Classificação Internacional dos Transtornos do Sono são de sonolência excessiva e cataplexia. Recomenda-se a realização de polissonografia seguida do teste de latência múltipla do sono em um laboratório de sono para confirmação e diagnóstico de comorbidades. Quando não houver cataplexia, deve haver duas ou mais sonecas com sono REM no teste de latência múltipla do sono. Tipagem HLA-DQB1*0602 positiva com níveis de hipocretina-1 abaixo de 110pg/mL devem estar presentes para o diagnóstico de narcolepsia sem cataplexia e sem sonecas com sono REM.

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Section: Narcolepsy Secondary To Medical or Neurological Illnessesmentioning

confidence: 99%

Diretrizes brasileiras para o diagnóstico de narcolepsia

Alóe

Alves

Araújo

et al. 2010

Rev. Bras. Psiquiatr.

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“…14,15 The hallmark symptom of narcolepsy type 1 is cataplexy, which is an intrusion into the wake state of the motor atonia generally found in rapid eye movement (stage R) sleep. Box 2 summarizes the symptoms that can be assessed when evaluating for narcolepsy type 1.…”

Section: Symptoms Of Central Disorders Of Hypersomnolencementioning

confidence: 99%

Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia

Berkowski

Shelgikar

2016

Sleep Medicine Clinics

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“…As a consequence, the total amount of sleep over 24 hours is virtually unaltered. 5,6 Cataplexy is the only specific symptom of narcolepsy. It is defined as sudden and transient episodes of bilateral loss of muscle tone of brief duration (less than two minutes), triggered by emotions -most reliably laughing or joking-with preserved consiousness.…”

Section: Clinical Features Of Narcolepsymentioning

confidence: 99%

Narcolepsy: Immunological aspects

Overeem

Black

Lammers

2008

Sleep Medicine Reviews

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Narcolepsy with cataplexy is a debilitating sleep disorder with an estimated prevalence of about 0.05%. Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus. Based on the very strong association with the HLA subtype DQB1*0602, it is currently hypothesized narcolepsy is caused by an autoimmune mediated process directed at the hypocretin neurons. So far however, studies focussing on general markers of (auto)immune activation, as well as humoral immunity against the hypocretin system have not yielded consistent results supporting this hypothesis. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. PRACTICE POINTSIn most cases, narcolepsy is a sporadic disorder, althoug first degree relatives have an increased risk.The association with HLA-DQB1*0602 is the strongest of any disorder, but up to 35% of the normal population is positive for this allele.Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus. This is reflected in undetectable hypocretin-1 levels in the CSF.An autoimmune mediated destruction of hypocretin neurons remains the most attractive mechanism, but no direct evidence for this theory is available as of yet. RESEARCH AGENDAAutoantibody screenings in serum and CSF of narcoleptic patients, acquired around disease onset.Studies on T-cell mediated (auto)immunity in relation to the hypocretin system Extend the studies looking for non-HLA factors influencing susceptibility to narcolepsy Additional (post-mortem) histopathological studies in narcolepsy, again particularly around disease onset To search for alternative mechanisms that could result in a hypocretin deficiency.

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Ambulatory 24 hour sleep-wake monitoring in narcolepsy-cataplexy compared to matched controls

Cited by 124 publications

References 11 publications

Diretrizes brasileiras para o diagnóstico de narcolepsia

Diretrizes brasileiras para o diagnóstico de narcolepsia

Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia

Narcolepsy: Immunological aspects

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