Ambient (desorption/ionization) mass spectrometry methods for pesticide testing in food: a review

Beneito‐Cambra, Miriam; Gilbert-López, Bienvenida; Moreno‐González, David; Bouza, Marcos; Franzke, Joachim; García-Reyes, Juan F.; Molina‐Díaz, Antonio

doi:10.1039/d0ay01474e

Cited by 46 publications

(18 citation statements)

References 131 publications

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“…A variety of novel ambient ionization techniques have been developed, which broaden the application of ambient MS largely, including forensics, environmental science, food and agriculture, clinical analyses, − reaction monitoring, − etc. Miniaturization of ion source (and of course mass analyzer) brought the hope of detecting bacteria, , warfare agents, illicit drugs or psychoactive substances, explosives, pesticides, and pollutants in remote fields. Portability is essential for on-site detection using a miniature MS system coupled with ambient ionization and determines the popularization of MS in our normal life .…”

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confidence: 99%

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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Current ambient ionization sources for mass spectrometry (MS) are typically connected to gas cylinders, high-voltage supply, injection pump, and other accessory equipment, which hinder the popularization of MS in the field of on-site detection. Here, we developed a wireless pocket-size "MasSpec Pointer" (weights 65 g) based on arc discharge powered by a 3.7 V polymer Li battery for ambient ionization MS. A high voltage of 5600 V and 20 kHz was generated from the boost coil to penetrate air and form a plasma. The relative standard deviation (RSD) of the high-voltage pulses is 3.8%, leading to a stable discharge and a good quantification performance. A mini diaphragm pump was used to cool the plasma from ∼600 to ∼40 °C and to blow the plasma into a jet, which facilitates sampling. MasSpec Pointer can work well at both positive-and negative-ion modes without any modification and can quickly test gaseous, liquid, or solid samples. The limit of detection of this device for atrazine (an agrochemical) is lower than 0.1 ng/mL. MasSpec Pointer has shown its ability to pinpoint the double-bond location of fatty acid isomers without derivatization reagents or light illumination. Agrochemicals from the surface of an apple and daily chemicals from the surface of a finger were detected successfully using MasSpec Pointer coupled with a miniature mass spectrometer. We believe the "point-and-shoot" device coupled with mini-MS brings the hope for an age of detecting chemicals on-site by nonprofessionals.

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confidence: 99%

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Chen

Meng

et al. 2021

Anal. Chem.

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“…The broad linear range of 3–4 orders of magnitude in the calibration curves as well as the possibility to directly measure compounds under native aqueous conditions with minimal sample preparations demonstrate the advantages of ambient ionization techniques. The overall sensitivity of the presented approach is comparable to other ambient sampling/ionization approaches. , However, further validation experiments have to be performed to fully evaluate the quantitative abilities, in particular in more complex sample matrixes.…”

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confidence: 99%

“…The overall sensitivity of the presented approach is comparable to other ambient sampling/ionization approaches. 32,33 However, further validation experiments have to be performed to fully evaluate the quantitative abilities, in particular in more complex sample matrixes.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Quantitative Analysis of Pharmaceutical Drugs Using a Combination of Acoustic Levitation and High Resolution Mass Spectrometry

et al. 2021

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A combination of acoustic levitation, laser vaporization, and atmospheric pressure chemical ionization mass spectrometry (APCI-MS) is presented in this study that enabled sensitive analysis of pharmaceutical drugs from an aqueous sample matrix. An unfocused pulsed infrared laser provided contactless sample desorption from the droplets trapped inside an acoustic levitator by activation of the OH stretching band of aqueous and alcoholic solvents. Subsequent atmospheric pressure chemical ionization was used between the levitated droplet and the mass spectrometer for postionization. In this setup, the unfocused laser gently desorbed the analytes by applying very mild repulsive forces. Detailed plume formation studies by temporally resolved schlieren experiments were used to characterize the liquid gas transition in this process. In addition, the role of different additives and solvent composition was examined during the ionization process. The analytical application of the technique and the proof-of-concept for quantitative analysis were demonstrated by the determination of selected pharmaceutical drugs in aqueous matrix with limits of quantification at the lower nanomolar level and a linear dynamic range of 3–4 orders of magnitude.

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“…Exogenous toxic and harmful substances mainly come from the external environment, and pollution to food, such as pesticides. They may occur in every link of the food supply chain [ 8 ], from the contamination of veterinary drugs [ 9 ], heavy metals and harmful elements [ 10 ], and from using food additives, antibiotics, dioxins, and their analogs. Microbial toxins consist mainly of bacterial and fungal toxins, such as cyanobacteria toxins, aflatoxin, etc.…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Applying Infrared Spectroscopy Technology for Detection of Toxic and Harmful Substances in Food

Tian

et al. 2022

Foods

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In recent years, food safety incidents have been frequently reported. Food or raw materials themselves contain substances that may endanger human health and are called toxic and harmful substances in food, which can be divided into endogenous, exogenous toxic, and harmful substances and biological toxins. Therefore, realizing the rapid, efficient, and nondestructive testing of toxic and harmful substances in food is of great significance to ensure food safety and improve the ability of food safety supervision. Among the nondestructive detection methods, infrared spectroscopy technology has become a powerful solution for detecting toxic and harmful substances in food with its high efficiency, speed, easy operation, and low costs, while requiring less sample size and is nondestructive, and has been widely used in many fields. In this review, the concept and principle of IR spectroscopy in food are briefly introduced, including NIR and FTIR. Then, the main progress and contribution of IR spectroscopy are summarized, including the model’s establishment, technical application, and spectral optimization in grain, fruits, vegetables, and beverages. Moreover, the limitations and development prospects of detection are discussed. It is anticipated that infrared spectroscopy technology, in combination with other advanced technologies, will be widely used in the whole food safety field.

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Ambient (desorption/ionization) mass spectrometry methods for pesticide testing in food: a review

Abstract: Ambient mass spectrometry refers to the family of techniques that allows ions to be generated from condensed phase samples under ambient conditions and then, collected and analysed by mass spectrometry....

Cited by 46 publications

References 131 publications

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry

Quantitative Analysis of Pharmaceutical Drugs Using a Combination of Acoustic Levitation and High Resolution Mass Spectrometry

Research Progress of Applying Infrared Spectroscopy Technology for Detection of Toxic and Harmful Substances in Food

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