Ambazone salt with p-aminobenzoic acid

Mureşan-Pop, Marieta; Kacsó, Irina; Martin, Flavia; Simon, S.; Ştefan, R.; Bratu, Ioan

doi:10.1007/s10973-015-4452-0

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…The derivatives of PABA showed improved radical scavenging properties and also enhanced toxicity for cancer cells [5]. PABA-ambazone salt exhibited improved antibacterial effect when compared to parent drugs [17]. Schiff bases with isatin ( Figure 2, XII) exhibited activity against various cancer cell lines [18].…”

Section: Introductionmentioning

confidence: 99%

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

et al. 2019

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4-aminobenzoic acid (PABA), an essential nutrient for many human pathogens, but dispensable for humans, and its derivatives have exhibited various biological activities. In this study, we combined two pharmacophores using a molecular hybridization approach: this vitamin-like molecule and various aromatic aldehydes, including salicylaldehydes and 5-nitrofurfural, via imine bond in one-step reaction. Resulting Schiff bases were screened as potential antimicrobial and cytotoxic agents. The simple chemical modification of non-toxic PABA resulted in constitution of antibacterial activity including inhibition of methicillin-resistant Staphylococcus aureus (minimum inhibitory concentrations, MIC, from 15.62 µM), moderate antimycobacterial activity (MIC ≥ 62.5 µM) and potent broad-spectrum antifungal properties (MIC of ≥ 7.81 µM). Some of the Schiff bases also exhibited notable cytotoxicity for cancer HepG2 cell line (IC 50 ≥ 15.0 µM). Regarding aldehyde used for the derivatization of PABA, it is possible to tune up the particular activities and obtain derivatives with promising bioactivities.

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Section: Introductionmentioning

confidence: 99%

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

et al. 2019

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Synthesis of the Three Mixed-ligand Metal Complexes and One Organic Salt of 3,5-Dinitrobenzoic Acid for Biopharmaceutical Optimization Through Monoethanolamine: Structures and DFT Studies of Complexes

2020

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para-Aminobenzoic Acid-A Substrate of Immense Significance

Nisa

Akhtar

2020

MROC

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PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression and irritability. Besides the its medicinal importance, PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles, azitidinones, thiazolidinones, pyrazoline, etc. This review will describe the applications of PABA in the synthesis of these biologically active nuclei and hence emphasizing its importance as a versatile substrate.

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Ambazone salt with p-aminobenzoic acid

Cited by 3 publications

References 24 publications

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

Synthesis of the Three Mixed-ligand Metal Complexes and One Organic Salt of 3,5-Dinitrobenzoic Acid for Biopharmaceutical Optimization Through Monoethanolamine: Structures and DFT Studies of Complexes

para-Aminobenzoic Acid-A Substrate of Immense Significance

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