para-Aminobenzoic Acid-A Substrate of Immense Significance

Abstract

PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression and irritability. Besides the its medicinal importance, PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles, azitidinones, thiazolidinones, pyrazoline, etc. This review will describe the applications of PABA in the synthesis of these biologically active nuclei and hence emphasizing its importance as a versatile substrate.

Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications

“…The chemistry of PABA involves the reactions of functional groups such as amino and carboxylic acid [11], while the amino group can undergo acylation with acetic anhydride to form an amide. The carboxyl group gives the esterification reaction with alcohol to form an ester [12].…”

“…It is clear from Figure 5 that such compounds having diverse functionalities have been prepared from PABA. Derivatives of PABA were synthesized as 1, 3, 5triazine [37], quinoxaline [38], thiosemicarbazides, semicarbazides [39], sulfonamide [40,41], acridine [42], organometallic-based compounds [6], phthalimide [43], α-amino phosphonates [44], nicotinamide [45], a coumarin-based Schiff base [46], p-aminobenzoic acid-A [11], p-nitrobenzoic acid [47], new azidosulfonamide chalcones [48], and rhodanine [49].…”

“…amino phosphonates [44], nicotinamide [45], a coumarin-based Schiff base [46], p-aminobenzoic acid-A [11], p-nitrobenzoic acid [47], new azidosulfonamide chalcones [48], and rhodanine [49].…”

“…4-aminobenzohydrazide compounds were synthesized from 4aminobenzoate by reacting with hydrazine in the presence of ethanol under reflux [53]. Hydrazine carboxamido benzoic acid derivatives were synthesized from the carbamate ester of PABA that was reacted with formate in alkaline conditions in the solution of 1,4- [6,11,[38][39][40][41][42][43][44][45][46][47][48][49]).…”

Novel 1,4-Dihydropyridine Derivatives as Potential Agents with Analgesic Activity IN Orofacial Trigeminal Pain Test: Experimental Preclinical Randomized Trial

“…Одним из главных направлений использования тиоамида является синтез широкого круга S, N-гетероциклических соединений, к важнейшим из которых следует отнести 3-цианопиридин-2 (1 Н)-тионы и 3-циано-1,4-дигидропиридин-2-тиолаты. Дериваты цианотиоацетамида пиридинового ряда в настоящее время можно считать весьма полезным объектом исследования для изыскания новых лекарственных средств с многочисленными фармакологическими свойствами, включая анальгетические [11][12][13][14][15][16][17][18][19][20]. [21].…”