Amazon-derived nutraceuticals: Promises to mitigate chronic inflammatory states and neuroinflammation

Assmann, Charles Elias; Weis, Grazielle Castagna Cezimbra; Rosa, Jéssica Righi da; Bonadiman, Beatriz da Silva Rosa; Alves, Audrei de Oliveira; Schetinger, Maria Rosa Chitolina; Ribeiro, Euler Esteves; Morsch, Vera Maria; Cruz, Ivana Beatrice Mânica da

doi:10.1016/j.neuint.2021.105085

Cited by 12 publications

(12 citation statements)

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“…Açai also presents vitamin C and carotenoids (Chang et al, 2019 ). These bioactive compounds contains in açai are associated with antioxidant, anti‐inflammatory, antiproliferative, and cardioprotective proprieties (Assmann et al, 2021 ; Bahadoran, Mirmiran, & Azizi, 2013 ; Kim, Lee, & Lee, 2011 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Tropical fruit consumption is increasing due to growing recognition of its nutritional and therapeutic value (Rufino, Alves, Fernandes, & Brito, 2011). Some fruits and seeds from the Amazon Biome consumed since the pre-Columbian period have been studied for their potential bioactive compound's sources such as carotenoids, polyphenols, unsaturated fatty acids, vitamins, and trace elements (Assmann et al, 2021;Cândido, Silva, & Agostini-Costa, 2015). Therefore, it is possible that some Amazonian fruits habitually consumed by riverine and indigenous populations could present relevant attenuative proprieties against complications triggered by COVID-19 infection from biochemical modulations of oxidative and inflammatory metabolism.…”

mentioning

confidence: 99%

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Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Manica-Cattani¹,

Hoefel²,

Azzolin³

et al. 2022

Journal of Food Biochemistry

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The COVID‐19 pandemic had a great impact on the mortality of older adults and, chronic non‐ transmissible diseases (CNTDs) patients, likely previous inflammaging condition that is common in these subjects. It is possible that functional foods could attenuate viral infection conditions such as SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2), the causal agent of COVID‐19 pandemic. Previous evidence suggested that some fruits consumed by Amazonian Diet from Pre‐Colombian times could present relevant proprieties to decrease of COVID‐19 complications such as oxidative‐cytokine storm. In this narrative review we identified five potential Amazonian fruits: açai berry (Euterpe oleracea), camu‐camu (Myrciaria dubia), cocoa (Theobroma cacao), Brazil nuts (Bertholletia excelsa), and guaraná (Paullinia cupana). Data showed that these Amazonian fruits present antioxidant, anti‐inflammatory and other immunomodulatory activities that could attenuate the impact of inflammaging states that potentially decrease the evolution of COVID‐19 complications. The evidence compiled here supports the complementary experimental and clinical studies exploring these fruits as nutritional supplement during COVID‐19 infection. Practical applications These fruits, in their natural form, are often limited to their region, or exported to other places in the form of frozen pulp or powder. But there are already some companies producing food supplements in the form of capsules, in the form of oils and even functional foods enriched with these fruits. This practice is common in Brazil and tends to expand to the international market.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Amazonian fruits with potential effects on COVID‐19 by inflammaging modulation: A narrative review

Manica-Cattani¹,

Hoefel²,

Azzolin³

et al. 2022

Journal of Food Biochemistry

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“…Figure 1. The global nutraceutical market and major consumers approximated using 2017 estimates in billions of USD from the following references [22][23][24][25][26][27][28][29][30][31].…”

Section: Insights Into the Global Marketmentioning

confidence: 99%

“…Moreover, consumers inclination towards consumption of healthy foods and supplements has increased in the older and middle-class populations, further boosting the sales of nutraceuticals throughout the country [46]. The Amazon due to its incredible biodiversity may also be a source of natural health products and nutraceuticals in time if responsibly managed [31].…”

Section: Central and Latin Americamentioning

confidence: 99%