Amadori Rearrangement

doi:10.1002/9780470638859.conrr017

Cited by 139 publications

References 75 publications

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Amadori Rearrangement

2010

Comprehensive Organic Name Reactions and Reagents

139

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It has been found that under acidic condition transformation of N ‐glycosides of aldoses into N ‐glycosides of corresponding ketoses takes place, More generally it is known as the conversion of aldimines into ketoamines. This reaction is referred to as the Amadori rearrangement. This reaction is often involved in the formation of complex glycation end products,which play very important roles in biological processes. Amadori rearrangement has been studied especially in D‐glucopyranosylamine in acetic acid This reaction has a wide application in preparation of glycoproteins and aminopolysaccharides.

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Amadori Rearrangement

2010

Comprehensive Organic Name Reactions and Reagents

139

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Mechanisms of Drug Metabolism

Foti

Rock

Wienkers

et al. 2012

Encyclopedia of Drug Metabolism and Interactions

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The study of drug metabolism places significant importance on the molecular properties of the substrate and the topography of the enzyme's active site. Mechanisms of drug metabolism focus on the different reactions catalyzed within each family of drug‐metabolizing enzymes as well as the chemistry involved in phase I and II reactions. Concepts explored include enzyme‐catalyzed reaction mechanisms, physicochemical properties of substrate molecules that result in favorable sites of metabolism for a given enzyme, and factors that contribute to the regioselectivity and stereoselectivity observed for phase I and II drug‐metabolizing enzymes.

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A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes

et al. 2013

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Increasing evidence links the complement system with complications of human diabetes. The complement regulatory protein CD59, an inhibitor of formation of membrane attack complex (MAC), is inhibited by hyperglycemia-induced glycation fostering increased deposition of MAC, a major effector of complement-mediated tissue damage. CD59, an ubiquitous GPI-anchored membrane protein, is shed from cell membranes by phospholipases generating a soluble form present in blood and urine. Methods We established an ELISA to measure serum/plasma glycated hCD59 (GCD59) and evaluated its potential as a diabetes biomarker. We used a synthetic peptide strategy to generate a) a mouse monoclonal antibody to capture hCD59, b) a rabbit monoclonal antibody to detect GCD59, and c) a GCD59 surrogate for assay standardization. ELISA conditions were optimized for precision, reproducibility and clinical sensitivity. The clinical utility of the assay was initially evaluated in 24 subjects with or without diabetes and further validated in a study that included 100 subjects with and 90 subjects without a diagnosis of diabetes. Results GCD59 a) was significantly higher in individuals with than in individual without diabetes, b) was independently associated with HbA1c, and) identified individuals with diabetes with high specificity and sensitivity. Conclusions We report the development and standardization of a novel, sensitive, and specific ELISA for measuring GCD59 in blood. The assay distinguished individuals with diabetes from those without, and showed strong correlation between GCD59 and HbA1c. Because GCD59 likely contributes to the pathogenesis of diabetes complications, measurement of blood levels of GCD59 may be useful in the diagnosis and management of diabetes.

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Amadori Rearrangement

Cited by 139 publications

References 75 publications

Amadori Rearrangement

Amadori Rearrangement

Mechanisms of Drug Metabolism

A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes

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