2013
DOI: 10.3233/jad-131034
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Abstract: We previously showed that mitochondria-targeted antioxidant SkQ1 (plastoquinonyl-decyltriphenylphosphonium) at nanomolar concentrations is capable of preventing and slowing down some cerebral dysfunctions in accelerated-senescence OXYS rats. Here we demonstrate that OXYS rats develop behavior, learning, and memory deficits against a background of neurodegeneration signs detected by magnetic resonance tomography and amyloid-β (Aβ) pathology similar to those seen in Alzheimer's disease (AD). Long-term treatment … Show more

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Cited by 67 publications
(66 citation statements)
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“…26 OXYS rats overproduce AβPP protein by 13 mo of age, and the protein levels remain high subsequently at 23 mo of age. 41 Thus, histopathologically, Aβ accumulates in the hippocampus and cortex of OXYS rats with age ( Fig. 4A-C).…”
Section: The Ad-like Metabolic Pathway In Oxys Ratsmentioning
confidence: 99%
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“…26 OXYS rats overproduce AβPP protein by 13 mo of age, and the protein levels remain high subsequently at 23 mo of age. 41 Thus, histopathologically, Aβ accumulates in the hippocampus and cortex of OXYS rats with age ( Fig. 4A-C).…”
Section: The Ad-like Metabolic Pathway In Oxys Ratsmentioning
confidence: 99%
“…Such lesions were not found in young Wistar rats. 41,63,67 Demyelination occurs both during healthy brain aging and in AD, but the magnitude of changes is significantly different. 68 With age, demyelination is detectable in Wistar rats, but in middle-aged and aged animals the number of demyelinating foci is smaller than that in age-matched OXYS rats (Fig.…”
Section: Signs Of Neurodegeneration In Oxys Ratsmentioning
confidence: 99%
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