Alzheimer’s Disease in the Danish Malnutrition Period 1999–2007

Sparre-Sørensen, Maja; Kristensen, Gustav

doi:10.3233/jad-150472

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…In the Dutch National Food Consumption Survey (DNFCS), up to 10% of community-living older adults (≥ 65 years) did not meet the estimated average requirement (EAR) of 0.7 g of protein per kg of body weight per day (g/kg BW/day) [ 5 ] and close to 10% of women > 71 years had protein intakes below the EAR in the National Health and Nutrition Examination Survey (NHANES) 2003–2004 [ 6 ]. Protein intakes below the current recommended dietary allowance (RDA) of 0.8 g/kg BW/day have been linked to adverse health outcomes, including physical impairment, muscle loss, dementia and mortality [ 7 – 9 ]. On average, older adults have lower protein intakes than their younger counterparts because of loss of independence, changes in oral health and taste perception and, higher incidence of chronic diseases and disabilities [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study

et al. 2017

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PurposeThe very old (aged ≥ 85 years), fastest growing age group in most western societies, are at especially high risk of muscle mass and strength loss. The amount, sources and timing of protein intake may play important roles in the aetiology and management of sarcopenia. This study investigated the prevalence and determinants of low protein intake in 722 very old adults participating in the Newcastle 85+ Study.MethodsProtein intake was estimated with 2 × 24-h multiple pass recalls (24 h-MPR) and contribution (%) of food groups to protein intake was calculated. Low protein intake was defined as intake < 0.8 g of protein per adjusted body weight per day. A backward stepwise multivariate linear regression model was used to explore socioeconomic, health and lifestyle predictors of protein intake.ResultsTwenty-eight percent (n = 199) of the community-living very old in the Newcastle 85+ Study had low protein intake. Low protein intake was less likely when participants had a higher percent contribution of meat and meat products to total protein intake (OR 0.97, 95% CI 0.95, 1.00) but more likely with a higher percent contribution of cereal and cereal products and non-alcoholic beverages. Morning eating occasions contributed more to total protein intake in the low than in the adequate protein intake group (p < 0.001). Being a woman (p < 0.001), having higher energy intake (p < 0.001) and higher tooth count (p = 0.047) was associated with higher protein intake in adjusted models.ConclusionThis study provides novel evidence on the prevalence of low protein intake, diurnal protein intake patterns and food group contributors to protein intake in the very old.Electronic supplementary materialThe online version of this article (doi:10.1007/s00394-017-1537-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study

et al. 2017

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“…Furthermore, relative to healthy controls, patients with AD have been reported to have impaired psycho‐functional performance – in terms of cognition, daily living activities and depressive symptoms – combined with a poorer nutritional status . Patients with AD have been found to have a higher than typical malnutrition‐related mortality rate , underscoring the importance of nutrition in patients diagnosed with neurodegenerative disorders. In this regard, chewing and swallowing capacities are indispensable for maintaining proper eating habits.…”

Section: Discussionmentioning

confidence: 99%

“…Sparre‐Sørensen et al . have argued convincingly that a balanced diet may reduce the risk of clinical worsening and delay AD onset.…”

Section: Introductionmentioning

confidence: 99%

Mandibular movements and bite force in Alzheimer's disease before and after new denture insertion

Campos

Ribeiro

Stella

et al. 2017

J of Oral Rehabilitation

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Chewing impairment has been observed in elders with Alzheimer's disease (AD); however, it is unknown whether oral rehabilitation can improve their masticatory function. This study evaluated the influence of new removable prostheses on chewing function of patients with AD. Participants using removable dentures were divided into two groups: patients with mild AD (77·2 ± 5·8 years, n = 16) and controls (76·0 ± 4·4, n = 16). All participants received general dental treatment and new total and/or partial removable prostheses. After 2 months of adaptation to the new dentures, chewing was evaluated by the following parameters: masticatory cycle time (CT), cycle velocity (CV), and opening (OA) and closing mandibular angles (CA), registered by a kinesiographic device. Maximum bite force (MBF) was assessed using a strain sensor. Evaluations were performed at baseline and after insertion of the new prostheses. A mixed model (α = 5%) was used for within- and between-subject analyses. After insertion of new prostheses, CT was reduced, and CV and MBF were increased in both groups (P < 0·05). There were no changes in OA or CA (P > 0·05). Compared to controls, elders with AD showed higher CT and reduced MBF and CV both at baseline and after insertion of new prostheses (P < 0·05). However, OA and CA did not differ between groups (P > 0·05). Insertion of new removable prostheses improved masticatory function in elders with and without AD, but patients with mild AD still had reduced chewing parameters compared to controls.

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“…177,178 Both are near endemic among elderly and AD populations, and are well associated with deleterious outcomes and prognosis. 179,180 It is currently unclear whether AD may be more strongly associated with malnourishment or higher fat and sugar consumption, or a complex mix of both. However, given that both dietary states are known to impact AD, either case implies that AD and diet may exert a self-modifying interaction, wherein each may modulate the other.…”

Section: Alzheimer's Disease Drugs and Dietmentioning

confidence: 99%

Nutrients in Alzheimer’s Disease: The Interaction of Diet, Drugs and Disease

Liyanage

Vilekar

Weaver

2019

Can. J. Neurol. Sci.

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In recent decades, clinical trials in Alzheimer’s disease (AD) have failed at an unprecedented rate. The etiology of AD has since come under renewed scrutiny, both to elucidate the underlying pathologies and to identify novel therapeutic strategies. Here, diet has emerged as a potential causative/protective agent. A variety of nutrients, including lipids, minerals, vitamins, antioxidants and sugars as well as broader dietary patterns and microbiotal interactions have demonstrated associations with AD. Although clinical trials have yet to definitively implicate any singular dietary element as therapeutic or causative, it is apparent that dietary preferences, likely in complex synergies, may influence the risk, onset and course of AD. This review catalogs the impact of major dietary elements on AD. It further examines an unexplored reciprocal association where AD may modulate diet, as well as how potential therapeutics may complicate these interactions. In doing so, we observe diet may have profound effects on the outcome of a clinical trial, either as a confounder of a drug/disease interaction or as a generally disruptive covariate. We therefore conclude that future clinical trials in AD should endeavor to control for diet, either in study design or subsequent analyses.

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Alzheimer’s Disease in the Danish Malnutrition Period 1999–2007

Abstract: The study concludes that the malnutrition period resulted in an excess death rate from Alzheimer's disease. All in all, a total of 345 extra lives were lost, and many might have developed AD earlier than they otherwise would, due to malnutrition.

Cited by 6 publications

References 16 publications

Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study

Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study

Mandibular movements and bite force in Alzheimer's disease before and after new denture insertion

Nutrients in Alzheimer’s Disease: The Interaction of Diet, Drugs and Disease

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